DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and kcnh7

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_021332696.1	Gene:	kcnh7 / 560289	ZFINID:	ZDB-GENE-120214-39	Length:	1177	Species:	Danio rerio

Alignment Length:	721	Identity:	161/721 - (22%)
Similarity:	284/721 - (39%)	Gaps:	173/721 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   583 WSMVVSMAFLYNFWVIIYRFAF-----QEINRRTIAIWFC-----LDYLSDFLYLIDILFHFRTG 637
            |..::.:..:|......|..||     :|..||... :.|     :|.:.|.::::|||.:|||.
Zfish   429 WDWLILLLVIYTAIFTPYSAAFLLNDPEEEKRRECG-YSCSPLNVVDLIVDIMFIVDILINFRTT 492

  Fly   638 YL--EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLS---------IGFNSILRSFRLVK 691
            |:  .:.|:...| |:..||.... |:||.:..:|.|.|...         ||.....|..|||:
Zfish   493 YINANEEVVSHPA-KIAVHYFKGW-FFIDMVAAIPFDLLIFEGGSDETTTLIGLLKTARLLRLVR 555

  Fly   692 IYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCLYHIIHK--------------N 738
            :.|      :.:|::.|     ..|::..|:.||    ||..|:::.|..              |
Zfish   556 VAR------KLDRYSEY-----GAAVLMLLMCIFALIAHWLACIWYAIGNVERLYLDHTIGWLDN 609

  Fly   739 NG--FGSRNWVYHDSESADVVKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFVILQLLFGLMLF 800
            .|  .|.:..:..|:....:..:|:.:.|:...:||::| ....|.:..|.:|.|..:|.|.:::
Zfish   610 LGISIGKQYNISDDASGPSIRDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMY 674

  Fly   801 ATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLW-LTQKCSDEERA 864
            |::.|:|:.|:..:.:....:..::..||.::|..::||.|:.::.::|.:.| .|.........
Zfish   675 ASIFGNVSAIIQRLYSGTARYHLQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMEV 739

  Fly   865 VSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYI 929
            :...|:.|:|:|.::::...|:..:.|:....|.|..|.:|.:.....|||.:...|:|...:|.
Zfish   740 LKGFPECLQADICLHLNKTLLQSCKAFRGATKGCLRALAMRFKTTHAPPGDTLVHGGDVLTALYF 804

  Fly   930 VNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFVLSKKDMWDVL 994
            :.||.::::.|:  .|:|.|.....|||  ::::.....:..|.||::.|.||..::::|:.:||
Zfish   805 LARGSIEILRDD--IVVAILGKNDIFGE--MIHLYAKPGKANADVRALSYCDLHTINREDLLEVL 865

  Fly   995 KEYPAARVRLESIAVKRLEKYKKAPLEKVKYFNVVAMGRCQSTPGLVESCGRTSLEEMWLPPATA 1059
            ..||            ....|..:.||..  ||
Zfish   866 DMYP------------EFSDYFLSNLELT--FN-------------------------------- 884

  Fly  1060 GASSLMHHHQALQQQHQASQQQPHRQESTQTS-SQTHGYSPRSYADRLARATDSPRSVSPSAHGS 1123
                       |:.::......|.|...|..| |.|.....|    :..|:||||  :.|| ...
Zfish   885 -----------LRDENSKDTTAPQRTLYTAVSDSDTEDPDVR----KRRRSTDSP--IRPS-RSD 931

  Fly  1124 EERPRSRTTSHHSIRPQSQPSHTGHICDSSSQLECYGAGVGGAGGGTTPLLGSHEVLEDEIKRLR 1188
            .||.|.|..            ||                          |.|..|..|||.:..|
Zfish   932 RERVRDREL------------HT--------------------------LPGKEEEEEDEEETSR 958

  Fly  1189 ERLHTVESENQALNTKLSQQQWD-LENRLAE----IEMQICGVSSTSSVDPENETEELERNRESI 1248
            . |...:|....|||.......| :||.|.:    :|...||.:..|:...:.|..:   :.||.
Zfish   959 P-LGLGQSLPVNLNTMPDPHTKDCVENNLFQKDVCVEEWPCGNADDSAKSQDREGGD---DCESD 1019

  Fly  1249 IXHGSV 1254
            |..|.:
Zfish  1020 ITFGEM 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	65/277 (23%)
		CAP_ED	890..1004	CDD:237999	31/113 (27%)
		DUF4655	1084..>1154	CDD:317882	19/70 (27%)
kcnh7	XP_021332696.1	PAS_9	29..129	CDD:315989
		Ion_trans	428..690	CDD:306908	65/274 (24%)
		CAP_ED	765..876	CDD:237999	32/126 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910