DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and PRKG1

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_006249.1	Gene:	PRKG1 / 5592	HGNCID:	9414	Length:	686	Species:	Homo sapiens

Alignment Length:	377	Identity:	79/377 - (20%)
Similarity:	139/377 - (36%)	Gaps:	108/377 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   730 CLYHI-------IHKNNGFGSRNWVYHDSESADVVKQYLQSYYWCTLALTTIGDLPKPRSKGEYV 787
            |:|.:       |.|....||..:|..|.: .:|.|:.::        |.|:|       .|: |
Human   133 CMYPVEYGKDSCIIKEGDVGSLVYVMEDGK-VEVTKEGVK--------LCTMG-------PGK-V 180

  Fly   788 FVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYL 852
            |..|.:|:.....||                         |||.:.::                |
Human   181 FGELAILYNCTRTAT-------------------------VKTLVNVK----------------L 204

  Fly   853 W-LTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDY 916
            | :.::|.......:.|       |....:::.||.|..||:.....|.:|...|....:..|:|
Human   205 WAIDRQCFQTIMMRTGL-------IKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEY 262

  Fly   917 ICRKGEVGKEMYIVNRGRLQVVADNGKT----VMASLKAGSYFGEISILNMGTAGNRRTASVRSV 977
            |.|:|..|...:|:::|.:.|..::..:    .:.:|..|.:|||.::    ...:.|||:|.:.
Human   263 IIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKAL----QGEDVRTANVIAA 323

  Fly   978 GYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYK-KAPLE---------KVKYFNVVAMG 1032
            ......|:.:    |..|.....   |:.::.|..|..: ||..|         |:..||::
Human   324 EAVTCLVIDR----DSFKHLIGG---LDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNII--- 378

  Fly  1033 RCQSTPGLVESCGRTSLEEMWLPPATAGASSLM---HHHQALQQQHQASQQQ 1081
               .|.| |...||..|.::....:...|..::   |.....||:|..|::|
Human   379 ---DTLG-VGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQ 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	20/95 (21%)
		CAP_ED	890..1004	CDD:237999	26/117 (22%)
		DUF4655	1084..>1154	CDD:317882
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375
		CAP_ED	118..227	CDD:237999	28/158 (18%)
		CAP_ED	237..341	CDD:237999	26/111 (23%)
		STKc_cGK	381..641	CDD:270724	12/47 (26%)
		S_TK_X	636..>679	CDD:214529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910