Protein Alignment CG42260 and hcn4

DIOPT Version :9

• Sequence 1: NP_001356969.1
• Gene: CG42260 / 37614
• FlyBaseID: FBgn0259145
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_686078.4
• Gene: hcn4 / 557843
• ZFINID: ZDB-GENE-050420-360
• Length: 1140
• Species: Danio rerio
• Alignment Length: 991
• Identity: 221/991 - (22%)
• Similarity: 370/991 - (37%)
• Gaps: 271/991 - (27%)

  Fly   399 MDLLHNKQRNKSRGRL---------KTAASGD---------------QPLLGTWNRSTGRGSQDN 439
            ||.||:..|.    ||         |.:..||               :||..:....:|..:...
Zfish     1 MDRLHSSMRK----RLYSLPQHIGQKASIMGDAEDSDKDTRRKSIRMKPLPTSGEIKSGESAIME 61

  Fly   440 TLAGGGATSLAMGGHNQYGGNYCNGTDRYPRSRSQQQGHHNAAQQAHHPYQLQHSASTVSHHPHA 504
            |..|....:.:.|...::.|:..:.|.|          |.:.:..|.....:.....|    |..
Zfish    62 TDIGRPVKTSSNGDCRRFRGSLSSITSR----------HVHDSDVAEERRLITDGEVT----PSE 112

  Fly   505 HGPPSQGGPGGPGPPHGGHPHHPHHGGAGSGGGSGPGSHGGQPHHQKPRRTA------------- 556
            ..||  |..||...|           ||.||||.|..:.|...|...|.:.|
Zfish   113 ESPP--GAAGGGAEP-----------GAQSGGGGGEEAAGSSQHQGIPDQQAGFIKLEGIEQILP 164

  Fly   557 ----------------------------------------SQRIRAATAARKLHFVFDPAGRLCY 581
                                                    .:|:::|.     .::..|.....:
Zfish   165 DDERYYQAGFMHRQFGAMLQPGVNKFSLRMFGSEKAVEREQERVKSAG-----FWIIHPYSDFRF 224

  Fly   582 YWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFRTGYLEDG---- 642
            ||.:.:.:..:.|..:|.....|  ........|...:.:||..:|:|::.:||||.:::.
Zfish   225 YWDLTMLLLMVGNLIIIPVGITF--FKDEHTPPWIVFNVVSDTFFLMDLVLNFRTGIVKEDNAEI 287

  Fly   643 VLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYL------------------SIGFNSILRSFRL 689
            :|....:|::  |:.|. |.:|.:..:|:|:::|                  .:.|..||...||
Zfish   288 ILDPQQIKIK--YLRSW-FVVDFISSIPVDYIFLIVETRIDSDFYKTARALRIVRFTKILSLLRL 349

  Fly   690 VKIYRFWAFMDRTER--HTNY---PNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWVYH 749
            :::.|...::.:.|.  |..|   ..:.|...||..:|::.||:|||..::.....|.:..||..
Zfish   350 LRLSRLIRYIHQWEEIFHMTYDLASAMVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPADCWVAK 414

  Fly   750 DSESADV-VKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVT 812
            :....|. .:||..:.:.....:..|| .:..|....:....||.::.|...:|..:||...::.
Zfish   415 NKMVNDTWGQQYSYALFKAMSHMLCIGYGMYPPVGMTDVWLTILSMIVGATCYAMFVGHATALIQ 479

  Fly   813 SVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIA 877
            |:.::|:::|.|...|:.||...::|..::.::..::::.: ..|..|||..:..|.:.|:.||
Zfish   480 SLDSSRRQYQEKYKQVEQYMSFHKLPADMRQRIHDYYEHRY-QGKMFDEESILGELNEPLREEI- 542

  Fly   878 INVHLDTL-KRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADN 941
            ||.:...| ..:.:|.|.:..|:..::.:||..:|.|||||.|:|.:||:||.:..|.:.|:...
Zfish   543 INFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG 607

  Fly   942 GKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLES 1006
            .|.  ..|..|||||||.:|..|    |||||||:..|..|:.||..:..:||:|||..|...|:
Zfish   608 NKE--TKLSDGSYFGEICLLTRG----RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFET 666

  Fly  1007 IAVKRLEKY-KKAPL--EKVKY---------------FNVVA----MGRCQSTPGLVES----CG 1045
            :|:.||::. ||..:  .||::               ..:|.    |..|.:   |::|    ..
Zfish   667 VALDRLDRIGKKNSILQHKVQHDLNSGVLNYQESEIIQQIVQHDRDMAHCAN---LLQSPSPPAP 728

  Fly  1046 RTSLEEMWLP---------PATAGASSLMHHHQALQ--------QQHQASQQQPHRQESTQTSSQ 1093
            .:....:|.|         .||...:..:.||..|.        ....:..:.|.|.:..||
Zfish   729 PSPTPVIWAPLIQAPLQAAAATTSVAIALTHHPHLPATLFRPPVSLLGSRNEPPSRLKRFQT--- 790

  Fly  1094 THGYSPRSYADRLARATDSPRSVSPS-AHGSEERP--RSRTTSHHSI--------------RPQS 1141
                    .|.|....|||| |.||| .|...:.|  .|..|.|.|:              |..|
Zfish   791 --------VAPRTGSTTDSP-STSPSKLHSGVDTPLLASLHTQHSSVTITPSATTNQPVSFRSFS 846

  Fly  1142 QPSHTGHICDS----------------SSQLECYGAGVGGAGGGTTPLLGSHEVLEDEIKRLRER 1190
            .||.:..:..:                |::|:..||...|.
Zfish   847 SPSASPTLSTAQLHPQPRQKQPSTPPLSARLQAAGAHPPGI------------------------ 887

  Fly  1191 LHTVESENQALNTKLS 1206
            |.|..|...||:..||
Zfish   888 LTTASSNTSALSAGLS 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	57/266 (21%)
		CAP_ED	890..1004	CDD:237999	47/113 (42%)
		DUF4655	1084..>1154	CDD:317882	23/102 (23%)
hcn4	XP_686078.4	Ion_trans_N	179..221	CDD:285597	3/46 (7%)
		Ion_trans	241..486	CDD:278921	54/249 (22%)
		Crp	550..>685	CDD:223736	54/140 (39%)
		CAP_ED	556..664	CDD:237999	47/113 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910