Protein Alignment CG42260 and hcn4l

DIOPT Version :10

• Sequence 1: NP_001356969.1
• Gene: CG42260 / 37614
• FlyBaseID: FBgn0259145
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_684730.6
• Gene: hcn4l / 556759
• ZFINID: ZDB-GENE-110411-3
• Length: 1188
• Species: Danio rerio
• Alignment Length: 853
• Identity: 200/853 - (23%)
• Similarity: 338/853 - (39%)
• Gaps: 197/853 - (23%)

  Fly   502 PHAHGPPSQGGPG-GPGPPHGGHPHHPHHGGAGSGGGSGPGS----------------------H 543
            |...||..|.||| .||.          .||.|.|....|..                      .
Zfish   115 PEDDGPSEQPGPGESPGA----------QGGRGDGAQQAPSEEQSTFVKLEGIDQILPDDERMYQ 169

  Fly   544 GGQPHHQ--------------------KPRRTASQRIRAATAARKLHFVFDPAGRLCYYWSMVVS 588
            .|..|.|                    |......:|:::|.     .::..|.....:||.:::.
Zfish   170 AGFMHRQFGAMLQPGVNKFSLRMFGSEKAVEHEQERVKSAG-----FWIIHPYSDFRFYWDLIML 229

  Fly   589 MAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFRTGYLEDG----VLQTDAL 649
            :..:.|..:|.....|.: :..|.| |...:.:||..:|:|::.:||||.:::.    :|....:
Zfish   230 LLMVGNLIIIPVGITFFK-DEHTPA-WIVFNVVSDTFFLVDLVLNFRTGIVKEDSTEIILDPQQI 292

  Fly   650 KLRTHYMNSTIFYIDCLCLLPLDFLYL------------------SIGFNSILRSFRLVKIYRFW 696
            |:|  |:.|. |.:|.|..:|:|:::|                  .:.|..||...||:::.|..
Zfish   293 KVR--YLRSW-FAVDFLSSIPVDYIFLIVETRIDSDFYKTARALRIVRFTKILSLLRLLRLSRLI 354

  Fly   697 AFMDRTER--HTNY---PNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWVYHDSESADV 756
            .::.:.|.  |..|   ..:.|...||..:|::.||:|||..::.....|.|..||..:....|.
Zfish   355 RYIHQWEEIFHMTYDLASAMVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVAKNKMVNDT 419

  Fly   757 -VKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARK 819
             .:||..:.:.....:..|| .:..|....:....||.::.|...:|..:||...::.|:.::|:
Zfish   420 WGQQYSYALFKAMSHMLCIGYGMYPPVGMTDVWLTILSMIVGATCYAMFVGHATALIQSLDSSRR 484

  Fly   820 EFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDT 884
            ::|.|...|:.||...::|..::.::..::::.: ..|..|||..:..|.:.|:.||   :..:.
Zfish   485 QYQEKYKQVEQYMSFHKLPADMRQRIHDYYEHRY-QGKMFDEESILGELNEPLREEI---ISFNC 545

  Fly   885 LKRV---EIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVM 946
            .|.|   .:|.|.:..|:..::.:||..:|.|||||.|:|.|||:||.:..|.|.|:....|.
Zfish   546 RKLVATMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTVGKKMYFIQHGVLTVLTKGSKE-- 608

  Fly   947 ASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKR 1011
            ..:..|||||||.:|..|    |||||||:..|..|:.||.....:||:|||..|...|::|:.|
Zfish   609 TKISDGSYFGEICLLTRG----RRTASVRADTYCRLYSLSVDHFNEVLEEYPMMRRAFETVALDR 669

  Fly  1012 LEKYKKAPLEKVKYFNVVAMGRCQSTPGLVESCGRTSLEEMWLPPATAGASSLMHHHQALQQQHQ 1076
            |::..|.        |.|...:.|..    .:.|..:.:|                ::.:||..|
Zfish   670 LDRIGKR--------NSVLQHKVQRD----LNSGVLNYQE----------------NEIIQQIVQ 706

  Fly  1077 ASQQQPHRQESTQT-----------SSQTHG-YSPRSYADRLARATDSPRSVSPSAHGSEERPRS 1129
            ..:...|.....||           ||.|.. ::|...|...|.|..:..:::.:.|     |.
Zfish   707 HDRDMAHCAHLMQTPPPPPHPAPTPSSHTPVIWAPLIQAPLQAAAATTSVAIALTRH-----PH- 765

  Fly  1130 RTTSHHSIRPQSQPSHTGHICDSSSQLECYGAGVGGA---GGGT-----------TPLLGSHEVL 1180
              ..|...||  .....|.:.|.....:.:...:.||   ||.:           ||:|
Zfish   766 --LPHTLFRP--PVPRLGSLKDQPGYFKRFPTALSGADTFGGSSSTSSQFSSCIETPIL------ 820

  Fly  1181 EDEIKRLRERLHTVESENQALNTKLSQQQWDLENRLAEIEMQICGVSSTSSVDPENETEELERNR 1245
             |.::..|....|....:.:|.|.::...                .::|||:     ||....:.
Zfish   821 -DTLRAERSSTSTPPPSSSSLPTTITTTV----------------TTTTSSI-----TESSHYHH 863

  Fly  1246 ESIIXHGS 1253
            ..|| |||
Zfish   864 RPIISHGS 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..820	CDD:459842	63/267 (24%)
		CAP_ED	890..1004	CDD:237999	48/113 (42%)
hcn4l	XP_684730.6	None