DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42260 and hcn4l

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_684730.5	Gene:	hcn4l / 556759	ZFINID:	ZDB-GENE-110411-3	Length:	1188	Species:	Danio rerio

Alignment Length:	853	Identity:	199/853 - (23%)
Similarity:	338/853 - (39%)	Gaps:	197/853 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   502 PHAHGPPSQGGPG-GPGPPHGGHPHHPHHGGAGSGGGSGPGS----------------------H 543
            |...||..|.||| .||.          .||.|.|....|..                      .
Zfish   115 PEDDGPSEQPGPGESPGA----------KGGRGDGAQQAPSEEQSTFVKLEGIDQILPDDERMYQ 169

  Fly   544 GGQPHHQ--------------------KPRRTASQRIRAATAARKLHFVFDPAGRLCYYWSMVVS 588
            .|..|.|                    |......:|:::|.     .::..|.....:||.:::.
Zfish   170 AGFMHRQFGAMLQPGVNKFSLRMFGSEKAVEHEQERVKSAG-----FWIIHPYSDFRFYWDLIML 229

  Fly   589 MAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFRTGYLEDG----VLQTDAL 649
            :..:.|..:|.....|.: :..|.| |...:.:||..:|:|::.:||||.:::.    :|....:
Zfish   230 LLMVGNLIIIPVGITFFK-DEHTPA-WIVFNVVSDTFFLVDLVLNFRTGIVKEDSTEIILDPQQI 292

  Fly   650 KLRTHYMNSTIFYIDCLCLLPLDFLYL------------------SIGFNSILRSFRLVKIYRFW 696
            |:|  |:.|. |.:|.|..:|:|:::|                  .:.|..||...||:::.|..
Zfish   293 KVR--YLRSW-FAVDFLSSIPVDYIFLIVETRIDSDFYKTARALRIVRFTKILSLLRLLRLSRLI 354

  Fly   697 AFMDRTER--HTNY---PNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWVYHDSESADV 756
            .::.:.|.  |..|   ..:.|...||..:|::.||:|||..::.....|.|..||..:....|.
Zfish   355 RYIHQWEEIFHMTYDLASAMVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVAKNKMVNDT 419

  Fly   757 -VKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARK 819
             .:||..:.:.....:..|| .:..|....:....||.::.|...:|..:||...::.|:.::|:
Zfish   420 WGQQYSYALFKAMSHMLCIGYGMYPPVGMTDVWLTILSMIVGATCYAMFVGHATALIQSLDSSRR 484

  Fly   820 EFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDT 884
            ::|.|...|:.||...::|..::.::..::::.: ..|..|||..:..|.:.|:.||   :..:.
Zfish   485 QYQEKYKQVEQYMSFHKLPADMRQRIHDYYEHRY-QGKMFDEESILGELNEPLREEI---ISFNC 545

  Fly   885 LKRV---EIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVM 946
            .|.|   .:|.|.:..|:..::.:||..:|.|||||.|:|.|||:||.:..|.|.|:....|.
Zfish   546 RKLVATMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTVGKKMYFIQHGVLTVLTKGSKE-- 608

  Fly   947 ASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKR 1011
            ..:..|||||||.:|..|    |||||||:..|..|:.||.....:||:|||..|...|::|:.|
Zfish   609 TKISDGSYFGEICLLTRG----RRTASVRADTYCRLYSLSVDHFNEVLEEYPMMRRAFETVALDR 669

  Fly  1012 LEKYKKAPLEKVKYFNVVAMGRCQSTPGLVESCGRTSLEEMWLPPATAGASSLMHHHQALQQQHQ 1076
            |::..|.        |.|...:.|..    .:.|..:.:|                ::.:||..|
Zfish   670 LDRIGKR--------NSVLQHKVQRD----LNSGVLNYQE----------------NEIIQQIVQ 706

  Fly  1077 ASQQQPHRQESTQT-----------SSQTHG-YSPRSYADRLARATDSPRSVSPSAHGSEERPRS 1129
            ..:...|.....||           ||.|.. ::|...|...|.|..:..:::.:.|     |.
Zfish   707 HDRDMAHCAHLMQTPPPPPHPAPTPSSHTPVIWAPLIQAPLQAAAATTSVAIALTRH-----PH- 765

  Fly  1130 RTTSHHSIRPQSQPSHTGHICDSSSQLECYGAGVGGA---GGGT-----------TPLLGSHEVL 1180
              ..|...||  .....|.:.|.....:.:...:.||   ||.:           ||:|
Zfish   766 --LPHTLFRP--PVPRLGSLKDQPGYFKRFPTALSGADTFGGSSSTSSQFSSCIETPIL------ 820

  Fly  1181 EDEIKRLRERLHTVESENQALNTKLSQQQWDLENRLAEIEMQICGVSSTSSVDPENETEELERNR 1245
             |.::..|....|....:.:|.:.::...                .::|||:     ||....:.
Zfish   821 -DTLRAERSSTSTPPPSSSSLPSTITTTV----------------TTTTSSI-----TESSVYHH 863

  Fly  1246 ESIIXHGS 1253
            ..||.|||
Zfish   864 RPIISHGS 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	62/266 (23%)
		CAP_ED	890..1004	CDD:237999	48/113 (42%)
		DUF4655	1084..>1154	CDD:317882	16/81 (20%)
hcn4l	XP_684730.5	Ion_trans_N	177..219	CDD:285597	4/46 (9%)
		Ion_trans	239..484	CDD:278921	59/249 (24%)
		Crp	548..>683	CDD:223736	56/148 (38%)
		CAP_ED	554..662	CDD:237999	48/113 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910