DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42260 and CNGB3

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_061971.3	Gene:	CNGB3 / 54714	HGNCID:	2153	Length:	809	Species:	Homo sapiens

Alignment Length:	595	Identity:	179/595 - (30%)
Similarity:	294/595 - (49%)	Gaps:	41/595 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   578 RLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILF-HFRTGYLED 641
            ||...|.::|::|:.:|...|..|..|.......|..|...|.:.|.:||.|:|| ..|..::..
Human   216 RLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRG 280

  Fly   642 GVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFNSILRSFRLVKIYRFWAFMDRTERHT 706
            |.:..|:.:||.||..||.|.:|...::|.|..||..|||.:.|:.|::|...|:.|....|...
Human   281 GDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFGFNPMFRANRMLKYTSFFEFNHHLESIM 345

  Fly   707 NYPNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWVYHDSESADVVKQYLQSYYWCTLAL 771
            :...::|......|||.|.|.|.|:|:......|.|:..||| |.|.    .:||:.|||....|
Human   346 DKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVY-DGEG----NEYLRCYYWAVRTL 405

  Fly   772 TTIGDLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRR 836
            .|||.||:|::..|.||.:|....|:.:|::::|.:.:::.:.:|.:..|:|.:|....||....
Human   406 ITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYS 470

  Fly   837 VPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCE 901
            :|..:|.:|..|::|.|.:|:..||...:..||..::..:||:|:...:.:|::|:..:...:.:
Human   471 IPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYD 535

  Fly   902 LVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVV-ADNGKTVMASLKAGSYFGEISILNMGT 965
            ::|||:.||:.|||::|:|||:||||||:..|.:||: ..:|..|:.:|||||.|||||:|..|
Human   536 MLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAG- 599

  Fly   966 AGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYP-AARVRLESIAVKRLEKYKKAPLEKVKYFNVV 1029
            .||||||:|.:.|:::|..|.||.:.::|..|| :.|:.::...|...:|.|.|.....:....:
Human   600 GGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSERILMKKARVLLKQKAKTAEATPPRKDLAL 664

  Fly  1030 AMGRCQSTPGLVES----CGRTSLEEMWLPPATAGASSLMHHHQALQ------------------ 1072
            .....:.||.|.::    .|:.||..:          ..:...||.|
Human   665 LFPPKEETPKLFKTLLGGTGKASLARL----------LKLKREQAAQKKENSEGGEEEGKENEDK 719

  Fly  1073 QQHQASQQQPHRQESTQTSSQTHGYSPRSYADRLARATDSPRSVSPSAHGSEERPRSRTTSHHSI 1137
            |:....:|:.:..:..:...:..|..|..........|.||.:|....|........|.||..|:
Human   720 QKENEDKQKENEDKGKENEDKDKGREPEEKPLDRPECTASPIAVEEEPHSVRRTVLPRGTSRQSL 784

  Fly  1138 RPQSQPSHTG 1147
            .....||..|
Human   785 IISMAPSAEG 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	76/238 (32%)
		CAP_ED	890..1004	CDD:237999	52/115 (45%)
		DUF4655	1084..>1154	CDD:317882	14/64 (22%)
CNGB3	NP_061971.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..121
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..178
		Ion_trans	238..453	CDD:278921	71/219 (32%)
		Crp	521..>648	CDD:223736	54/127 (43%)
		CAP_ED	524..639	CDD:237999	52/115 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	698..776		12/77 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920