DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and Cngb3

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_001258167.1	Gene:	Cngb3 / 500418	RGDID:	1565364	Length:	690	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	157/489 - (32%)
Similarity:	264/489 - (53%)	Gaps:	27/489 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   538 SGPGSHGGQPHHQKPRRTASQRIRAATAARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRF 602
            |.|..|    ||:..|....:.:|:....|.:....|   |:...|.::|::|:.:|.|::..|.
  Rat   171 SKPKEH----HHKLQRVPVKEYLRSMRLPRSIDSYTD---RIYLLWLLLVTIAYNWNCWLLPVRL 228

  Fly   603 AF--QEINRRTIAIWFCLDYLSDFLYLIDI-LFHFRTGYLEDGVLQTDALKLRTHYMNSTIFYID 664
            .|  |..:.|.  .|...|.:.|.:||.|| |...|..::..|.:..|:.:|:.||.:||.|.:|
  Rat   229 VFPCQTPDNRN--YWIITDIICDIIYLGDILLIQPRLQFVRGGEIIVDSNELKRHYRSSTKFQMD 291

  Fly   665 CLCLLPLDFLYLSIGFNSILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIFHWNG 729
            ...|||.:.||:..|.|.|.|:.|::|...|:.|....|...:...::|......|||.:.|.|.
  Rat   292 VASLLPFEVLYIFFGVNPIFRTNRILKYTSFFEFNHHLESIMDRAYVYRIIRTTGYLLFLLHINA 356

  Fly   730 CLYHIIHKNNGFGSRNWVYHDSESADVVKQYLQSYYWCTLALTTIGDLPKPRSKGEYVFVILQLL 794
            |:|:......|.||..|||:...:     :||:.:||....|.|||.||:|::..|.||.:|...
  Rat   357 CVYYWASDYEGIGSTKWVYNGEGN-----KYLRCFYWAVRTLITIGGLPEPQTSFEIVFQLLNFF 416

  Fly   795 FGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCS 859
            .|:.:|::::|.:.:::.:.:|.:..|...:|.:..||....:|...|.:|..|.:|.|.:|:..
  Rat   417 SGVFVFSSLIGQMRDVIGAATANQNNFHVCMDHIIAYMNKYSIPQSTQHRVRTWLEYTWHSQRIL 481

  Fly   860 DEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVG 924
            ||...:..||..::..:||:::.:.:.:||:|:..:...:.:|:|||:..::.|||::|:|||:|
  Rat   482 DESNLLETLPTAMQLSVAIDINFNIIDKVELFKGCDTQMIYDLLLRLKSTIYLPGDFVCKKGEIG 546

  Fly   925 KEMYIVNRGRLQVV-ADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFVLSKK 988
            |||||:..|.:||: ..:|..|:.:||||:.|||||:|..| .||||||.|.:.|:::|..|.||
  Rat   547 KEMYIIKHGEVQVLGGPDGAQVLVTLKAGAVFGEISLLAKG-GGNRRTADVVAHGFANLLTLDKK 610

  Fly   989 DMWDVLKEYPAARVRLESIAVKRLEKYKKAPLEK 1022
            .:.::|..||.::        |.|.|..|..|.:
  Rat   611 TLQEILLHYPTSK--------KLLMKKAKVLLSQ 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	74/240 (31%)
		CAP_ED	890..1004	CDD:237999	49/114 (43%)
		DUF4655	1084..>1154	CDD:317882
Cngb3	NP_001258167.1	CAP_ED	512..620	CDD:237999	47/108 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920