Protein Alignment CG42260 and KCNH2

DIOPT Version :10

• Sequence 1: NP_001356969.1
• Gene: CG42260 / 37614
• FlyBaseID: FBgn0259145
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_047276304.1
• Gene: KCNH2 / 3757
• HGNCID: 6251
• Length: 1185
• Species: Homo sapiens
• Alignment Length: 1038
• Identity: 206/1038 - (19%)
• Similarity: 385/1038 - (37%)
• Gaps: 247/1038 - (23%)

  Fly   302 GGGGGSGGGGAAIHTTELSITPTMAGDEQFIDLGSLRRFSIDRQSFLD-----LGPK------FG 355
            ||.||:|..||.:  .::.:||.....|.         .::|..:.:|     |||.      .|
Human   209 GGAGGAGAPGAVV--VDVDLTPAAPSSES---------LALDEVTAMDNHVAGLGPAEERRALVG 262

  Fly   356 MTQPKF---GQSVSQQGFFTSHDSLATPCA-----SRASNSHMATVSTASEMD-----LLHNKQR 407
            ...|..   ||..|.:....:.|:..:.|:     ||.|.:.:...|:|.:::     :|....|
Human   263 PGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPPR 327

  Fly   408 NKSRGRLKTAASGDQPLLGTWNRSTGRGSQDNTLAGGGATS----LAMGGHNQYGGNYCNG--TD 466
            :.|.|.:....||   ||.:        :.|:.|......|    :.:...:..|..:...  :|
Human   328 HASTGAMHPLRSG---LLNS--------TSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSD 381

  Fly   467 RYPRSRSQQQGHHNAAQQAHH----------PYQLQHSASTVSHHPHAHGPPSQGGPGGPGPPHG 521
            |...:...::..||..::...          .|:||
Human   382 REIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQ----------------------------- 417

  Fly   522 GHPHHPHHGGAGSGGGSGPGSHGGQPHHQKPRRTASQRIRAATAARKLHFVFDPAGRLCYYWSMV 586
                             .|..|.....|..|.:..                          |..:
Human   418 -----------------APRIHRWTILHYSPFKAV--------------------------WDWL 439

  Fly   587 VSMAFLYNFWVIIYRFAF-----QEINRRTIAIWFC-----LDYLSDFLYLIDILFHFRTGYL-- 639
            :.:..:|......|..||     :|....|...:.|     :|.:.|.::::|||.:|||.|:
Human   440 ILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNA 504

  Fly   640 -EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFNSIL------RSFRLVKIYRFWA 697
             |:.|....  ::..||.... |.||.:..:|.|.|....|...::      |..|||::.|
Human   505 NEEVVSHPG--RIAVHYFKGW-FLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVAR--- 563

  Fly   698 FMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCLYHII------HKNNGFGSRNWVYHDSE 752
               :.:|::.|     ..|::..|:..|    ||..|:::.|      |.::..|   |:::..:
Human   564 ---KLDRYSEY-----GAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIG---WLHNLGD 617

  Fly   753 ------------SADVVKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFVILQLLFGLMLFATVL 804
                        ...:..:|:.:.|:...:||::| ....|.:..|.:|.|..:|.|.:::|::.
Human   618 QIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIF 682

  Fly   805 GHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLP 869
            |:|:.|:..:.:....:..::..|:.::|..::||.|:.::.::|.:.|......|....:...|
Human   683 GNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFP 747

  Fly   870 DKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGR 934
            :.|:|:|.::::...|:..:.|:....|.|..|.::.:.....|||.:...|::...:|.::||.
Human   748 ECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGS 812

  Fly   935 LQVVADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPA 999
            ::::  .|..|:|.|.....|||  .||:.....:....||::.|.||..:.:.|:.:||..||
Human   813 IEIL--RGDVVVAILGKNDIFGE--PLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYP- 872

  Fly  1000 ARVRLESIAVKRLEKYKKAPLEKVKYFNVVAMGRCQSTPGLVESCGRTSLEEMWLPPATAGASSL 1064
                       ....:..:.||..  ||:      :.|..:..|.|.|.||        .|.|..
Human   873 -----------EFSDHFWSSLEIT--FNL------RDTNMIPGSPGSTELE--------GGFSRQ 910

  Fly  1065 MHHHQALQQQHQASQQQPHRQESTQTSSQTHGYSPRSYADRLARATDSPRSVSPSAHGSEERPRS 1129
            .....:.:::.....:||  .|.:.......|..|.|.........:||.|...|...||:....
Human   911 RKRKLSFRRRTDKDTEQP--GEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPG 973

  Fly  1130 RTTSHHSIRPQSQPSHTG---------HICDSSSQLECYGAGVGGAGGGTTPLLGSHEVLEDEIK 1185
            |::|...:.|.|.|...|         ..|:.||. .|  ..:.||..|.:.:.   ....|...
Human   974 RSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSD-TC--NPLSGAFSGVSNIF---SFWGDSRG 1032

  Fly  1186 RLRERLHTVESENQA-LNTKLS----QQQWDLENRLAEIEMQICGVSSTSSVDPENETEELER 1243
            |..:.|....:...: ||..||    :.:.|:|:||..::.|:..:.:..|.|.....:.|:|
Human  1033 RQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQR 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..820	CDD:459842	60/280 (21%)
		CAP_ED	890..1004	CDD:237999	30/113 (27%)
KCNH2	XP_047276304.1	PAS_9	64..156	CDD:463873
		Ion_trans	435..694	CDD:459842	60/301 (20%)
		CAP_ED	768..879	CDD:237999	30/126 (24%)