DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42260 and HCN1

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_066550.2	Gene:	HCN1 / 348980	HGNCID:	4845	Length:	890	Species:	Homo sapiens

Alignment Length:	930	Identity:	225/930 - (24%)
Similarity:	366/930 - (39%)	Gaps:	218/930 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 PRSRSQQQGHHNAAQQAHHPYQLQHSASTVSHHPHA-----HGPPSQGGPGGPGPPHGGHPHHPH 528
            |.|.|..:...|:...|        .||.....|.|     ..||..||.|  ...||.......
Human     7 PNSSSNSRDDGNSVFPA--------KASATGAGPAAAEKRLGTPPGGGGAG--AKEHGNSVCFKV 61

  Fly   529 HGGAGSGGGSGPGSH--GGQPHHQKPRRT------------------------ASQRI------R 561
            .||.|.|||.|.|..  ||....:.|||.                        .||:.      |
Human    62 DGGGGGGGGGGGGEEPAGGFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQER 126

  Fly   562 AATAARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLY 626
            ..||.   .::..|.....:||.:::.:..:.|..:|.....|  ...:|...|...:..||.::
Human   127 VKTAG---FWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITF--FTEQTTTPWIIFNVASDTVF 186

  Fly   627 LIDILFHFRTGYL-EDG---VLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYL----------- 676
            |:|::.:||||.: ||.   :|....:|:  :|:.|. |.:|.:..:|:|:::|
Human   187 LLDLIMNFRTGTVNEDSSEIILDPKVIKM--NYLKSW-FVVDFISSIPVDYIFLIVEKGMDSEVY 248

  Fly   677 -------SIGFNSILRSFRLVKIYRFWAFMDRTER--HTNY---PNLFRSTALIHYLLVIFHWNG 729
                   .:.|..||...||:::.|...::.:.|.  |..|   ..:.|...||..:|::.||:|
Human   249 KTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDG 313

  Fly   730 CLYHIIHKNNGFGSRNWV-----YHDSESADVVKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVF 788
            ||..::.....|....||     .:||..    |||..:.:.....:..|| ....|.|..:...
Human   314 CLQFLVPLLQDFPPDCWVSLNEMVNDSWG----KQYSYALFKAMSHMLCIGYGAQAPVSMSDLWI 374

  Fly   789 VILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLW 853
            .:|.::.|...:|..:||...::.|:.::|:::|.|...|:.||...::|..::.|:..::::.:
Human   375 TMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRY 439

  Fly   854 LTQKCSDEERAVSCLPDKLKAEIAINVHLDTL-KRVEIFQNTEAGFLCELVLRLRPVLFSPGDYI 917
             ..|..|||..::.|.|.|:.|| :|.:...| ..:.:|.|.:..|:..::.:||..:|.|||||
Human   440 -QGKIFDEENILNELNDPLREEI-VNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYI 502

  Fly   918 CRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDL 982
            .|:|.|||:||.:..|...|:..:.|.:  .|..|||||||.:|..|    |||||||:..|..|
Human   503 IREGAVGKKMYFIQHGVAGVITKSSKEM--KLTDGSYFGEICLLTKG----RRTASVRADTYCRL 561

  Fly   983 FVLSKKDMWDVLKEYPAARVRLESIAVKRLE---------------------------------- 1013
            :.||..:..:||:|||..|...|::|:.||:
Human   562 YSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIV 626

  Fly  1014 KYKKAPLEKVKYFNVVAMGRCQSTPGLVESCGRTSLEEMWLPPATAGASSLMHHHQALQQQHQAS 1078
            |:.:..::.:...|...|....||........|...:.   ||... |:||.|     ...|..|
Human   627 KHDREMVQAIAPINYPQMTTLNSTSSTTTPTSRMRTQS---PPVYT-ATSLSH-----SNLHSPS 682

  Fly  1079 QQQPHRQESTQTSSQTHGYSPRSYADRLARATDSPRSVSPSAHGS--------------EERPRS 1129
                   .||||...:...||.||    ..|..||...||.|..:              :::|:.
Human   683 -------PSTQTPQPSAILSPCSY----TTAVCSPPVQSPLAARTFHYASPTASQLSLMQQQPQQ 736

  Fly  1130 RTTSHHSIRPQSQPSHTGHICDSSSQLECYGAGVGGAGGGTTPLLGSHEVLEDEIKRLRERLHTV 1194
            :.  ..|..||:||.      ..|.|.:        ..|.:||        ::|:.:..:.||..
Human   737 QV--QQSQPPQTQPQ------QPSPQPQ--------TPGSSTP--------KNEVHKSTQALHNT 777

  Fly  1195 ESENQA-------------LNTKLSQQQWDLENRLAEIEMQICGVSSTS------SVDPENETEE 1240
            ....:.             ::|.:|:....:...||.|...:..|..|.      |..|:..|
Human   778 NLTREVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVT-- 840

  Fly  1241 LERNRESIIXHGSVLPHQAI 1260
            |.|...|    |::.|::.:
Human   841 LFRQMSS----GAIPPNRGV 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	62/270 (23%)
		CAP_ED	890..1004	CDD:237999	48/113 (42%)
		DUF4655	1084..>1154	CDD:317882	20/83 (24%)
HCN1	NP_066550.2	Disordered. /evidence=ECO:0000305\|PubMed:28086084	1..93		29/95 (31%)
		Ion_trans_N	98..140	CDD:285597	6/44 (14%)
		Ion_trans	160..405	CDD:278921	59/253 (23%)
		Selectivity filter. /evidence=ECO:0000305\|PubMed:28086084	358..362		2/3 (67%)
		Crp	469..>604	CDD:223736	53/140 (38%)
		CAP_ED	475..583	CDD:237999	48/113 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..692		16/63 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	725..796		14/94 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	845..890		3/16 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910