DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and Cngb1

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_001182342.1	Gene:	Cngb1 / 333329	MGIID:	2664102	Length:	1325	Species:	Mus musculus

Alignment Length:	678	Identity:	211/678 - (31%)
Similarity:	337/678 - (49%)	Gaps:	76/678 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   547 PHHQKPRRTASQRIRAATAARKLHFV--------------------FDPAGRLCY-YWSMVVSMA 590
            |..:.|....:|:...|..|.:.|:.                    .||...|.| .|...|.:|
Mouse   678 PAKKAPEPDPAQKPAEAEVAEEEHYCDMLCCKFKRRPLKMYRFPQSIDPLTNLMYILWLFFVVLA 742

  Fly   591 FLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDI-LFHFRTGYLEDGVLQTDALKLRTH 654
            :.:|.|:|..|:||.......|..|..:|||.||:||:|| :|..|..:::.|.:.||..::|.:
Mouse   743 WNWNCWLIPVRWAFPYQRADNIHFWLLMDYLCDFIYLLDITVFQMRLQFVKGGDIITDKKEMRNN 807

  Fly   655 YMNSTIFYIDCLCLLPLDFLYLSIGFNSILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIH 719
            |:.|..|.:|.|||||||||||.:|.|.:||..|.:|...|:.|.:|.|...:...::|......
Mouse   808 YLKSRRFKMDLLCLLPLDFLYLKLGINPLLRLPRCLKYMAFFEFNNRLEAILSKAYVYRVIRTTA 872

  Fly   720 YLLVIFHWNGCLYHIIHKNNGFGSRNWVYHDSESADVVKQYLQSYYWCTLALTTIGDLPKPRSKG 784
            |||...|.|.|||:......|.||.:|||.     .|...|::.|||....|.|||.||.|::..
Mouse   873 YLLYSLHLNSCLYYWASAFQGIGSTHWVYD-----GVGNSYIRCYYWAVKTLITIGGLPDPQTLF 932

  Fly   785 EYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWF 849
            |.||.:|....|:..|:.::|.:.::|.:.:|.:..:::.:|....||...::|..:|.:|..|:
Mouse   933 EIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPRSVQNRVKTWY 997

  Fly   850 DYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPG 914
            :|.|.:|...||...:..||||::.::||:|:...:.:|.:||..:...:.:::.|||.|::.|.
Mouse   998 EYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYSIVSKVALFQGCDRQMIFDMLKRLRSVVYLPN 1062

  Fly   915 DYICRKGEVGKEMYIVNRGRLQVV-ADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVG 978
            ||:|:|||:|:||||:..|::||: ..:||.|:.:|||||.|||||:|.:| .||||||:|.:.|
Mouse  1063 DYVCKKGEIGREMYIIQAGQVQVLGGPDGKAVLVTLKAGSVFGEISLLAVG-GGNRRTANVVAHG 1126

  Fly   979 YSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAPLEKVKYFNVVAMGRCQSTPGL--- 1040
            :::||:|.|||:.::|..||.::..|...|.:.|....|...||    :|:.:.....||.|
Mouse  1127 FTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRNNNKPKEEK----SVLILPPRAGTPKLFNA 1187

  Fly  1041 -VESCGRTSLEEMWLPPATAGASSLMHHHQALQQ--QHQASQQQPHRQESTQTSSQTHGYSPRSY 1102
             :.:.|:       :.|..|....|.|....|::  ..:|:.:|....|..::|.:..|
Mouse  1188 ALAAAGK-------MGPRGAKGGKLAHLRARLKELAALEAAARQQQLLEQAKSSQEAGG------ 1239

  Fly  1103 ADRLARATDSPRSVSPSAHGSEERPRSRTTSHHSIRPQSQPSHTGHICDSSSQLECYGAGVG--- 1164
             :..:.|||.|....|..  .::.|:.......|.:....|:       |:...|..|...|
Mouse  1240 -EEGSGATDQPAPQEPPE--PKDPPKPPGPPEPSAQSSPPPA-------SAKPEESTGEAAGPPE 1294

  Fly  1165 ---------GAGGGTTPLLGSHEVLEDE 1183
                     |...|...|  |.||||::
Mouse  1295 PSVRIRVSPGPDPGEQTL--SVEVLEEK 1320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	88/239 (37%)
		CAP_ED	890..1004	CDD:237999	53/114 (46%)
		DUF4655	1084..>1154	CDD:317882	12/69 (17%)
Cngb1	NP_001182342.1	Ion_trans	756..957	CDD:278921	77/205 (38%)
		Crp	1032..>1165	CDD:223736	57/133 (43%)
		CAP_ED	1038..1147	CDD:237999	52/109 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920