Protein Alignment CG42260 and Hcn4

DIOPT Version :9

• Sequence 1: NP_001356969.1
• Gene: CG42260 / 37614
• FlyBaseID: FBgn0259145
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: NP_001074661.1
• Gene: Hcn4 / 330953
• MGIID: 1298209
• Length: 1201
• Species: Mus musculus
• Alignment Length: 1059
• Identity: 236/1059 - (22%)
• Similarity: 387/1059 - (36%)
• Gaps: 284/1059 - (26%)

  Fly   228 RDHSSRSI--NPLTAYEQQMAELDGSFYASNAGYLGAGMGGSAGDGTTCTNLTVGGGSTGG---- 286
            :|.|.|||  .||.:....:|       |..:...||.:|.:..:|   ...:.|..||.|
Mouse    41 QDPSRRSIRLRPLPSPSPSVA-------AGCSESRGAALGATESEG---PGRSAGKSSTNGDCRR 95

  Fly   287 --GAMASGGGGTSAQVGGGGGGSGGGGAAIHTTELSITPTMAGDEQFIDLGSLRRFSIDRQSFL- 348
              |::||.|..     |||.||:|||.:                     ||.|...:.:|:...
Mouse    96 FRGSLASLGSR-----GGGSGGAGGGSS---------------------LGHLHDSAEERRLIAA 134

  Fly   349 --DLGPKFGMTQPKFGQSVSQQGFFTSHDSLATPCASRASNSHMATVSTASEMDLLHNKQRNKSR 411
              |..|         |:..:..|..|..:..||.....||.........||
Mouse   135 EGDASP---------GEDRTPPGLATEPERPATAAQPAASPPPQQPPQPAS-------------- 176

  Fly   412 GRLKTAASGDQPLLGTWNRSTGRGSQDNTLAGGGATSLAMGG--HNQYGGNYCNGTDRYPRSRSQ 474
                  ||.:||...|..:..|..:..:.:.......|...|  ..|:|.....|.::
Mouse   177 ------ASCEQPSADTAIKVEGGAAASDQILPEAEVRLGQSGFMQRQFGAMLQPGVNK------- 228

  Fly   475 QQGHHNAAQQAHHPYQLQHSASTVSHHPHAHGPPSQGGPGGPGPPHGGHPHHPHHGGAGSGGGSG 539
                          :.|:...|
Mouse   229 --------------FSLRMFGS------------------------------------------- 236

  Fly   540 PGSHGGQPHHQKPRRTASQRIRAATAARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAF 604
                      ||......:|:::|.     .::..|.....:||.:.:.:..:.|..:|.....|
Mouse   237 ----------QKAVEREQERVKSAG-----FWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITF 286

  Fly   605 QEINRRTIAIWFCLDYLSDFLYLIDILFHFRTG-YLEDGV-LQTDALKLRTHYMNSTIFYIDCLC 667
            .:....|  .|...:.:||..:|||::.:|||| .:||.. :..|..:::..|:.|. |.:|.:.
Mouse   287 FKDENTT--PWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSW-FVVDFIS 348

  Fly   668 LLPLDFLYL------------------SIGFNSILRSFRLVKIYRFWAFMDRTER--HTNY---P 709
            .:|:|:::|                  .:.|..||...||:::.|...::.:.|.  |..|   .
Mouse   349 SIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLAS 413

  Fly   710 NLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWV-YHDSESADVVKQYLQSYYWCTLALTT 773
            .:.|...||..:|::.||:|||..::.....|....|| .:...:....|||..:.:.....:..
Mouse   414 AVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPHDCWVSINGMVNNSWGKQYSYALFKAMSHMLC 478

  Fly   774 IG-DLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRV 837
            || ....|....:....:|.::.|...:|..:||...::.|:.::|:::|.|...|:.||...::
Mouse   479 IGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKL 543

  Fly   838 PNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTL-KRVEIFQNTEAGFLCE 901
            |...:.::..::::.: ..|..|||..:..|.:.|:.|| ||.:...| ..:.:|.|.:..|:..
Mouse   544 PPDTRQRIHDYYEHRY-QGKMFDEESILGELSEPLREEI-INFNCRKLVASMPLFANADPNFVTS 606

  Fly   902 LVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTA 966
            ::.:||..:|.|||||.|:|.:||:||.:..|.:.|:....|.  ..|..|||||||.:|..|
Mouse   607 MLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKE--TKLADGSYFGEICLLTRG-- 667

  Fly   967 GNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAP---LEKVKY--- 1025
              |||||||:..|..|:.||..:..:||:|||..|...|::|:.||::..|..   |.||::
Mouse   668 --RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLN 730

  Fly  1026 ---FN---------VV----AMGRCQSTPGLVESCGRTSLEEMWLP---------PATAGASSLM 1065
               ||         :|    .|..|........|...|....:|.|         .||...:..:
Mouse   731 SGVFNYQENEIIQQIVRHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIAL 795

  Fly  1066 HHHQAL--------------------QQQH-------------QASQQQPHRQESTQTSSQTH-- 1095
            .||..|                    ..:|             .||......|..|.:||..|
Mouse   796 THHPRLPAAIFRPPPGPGLGNLGAGQTPRHPRRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQ 860

  Fly  1096 ---GYS-PRSYADRLARATDSPRSVSPSAHGSEERPRSRTTSHHSIRPQSQPSHTGHICDSSSQL 1156
               |:| |...:..|..::.||   .|.|.||...|...|    |....:..:..||
Mouse   861 QLAGFSAPPGLSPLLPSSSSSP---PPGACGSPPAPTPST----STAAAASTTGFGH-------- 910

  Fly  1157 ECYGAGVGGA-GGGTTPLL 1174
              :...:||: ....:|||
Mouse   911 --FHKALGGSLSSSDSPLL 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	59/264 (22%)
		CAP_ED	890..1004	CDD:237999	47/113 (42%)
		DUF4655	1084..>1154	CDD:317882	20/75 (27%)
Hcn4	NP_001074661.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..121		30/115 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	135..183		14/76 (18%)
		Involved in subunit assembly. /evidence=ECO:0000250	209..260		11/129 (9%)
		Ion_trans_N	218..260	CDD:285597	9/120 (8%)
		Ion_trans	280..525	CDD:278921	56/247 (23%)
		Crp	589..>724	CDD:223736	54/140 (39%)
		CAP_ED	595..703	CDD:237999	47/113 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	804..902		21/104 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	914..1201		5/14 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3583
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.960