DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and AgaP_AGAP011459

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_554755.3	Gene:	AgaP_AGAP011459 / 3291342	VectorBaseID:	AGAP011459	Length:	926	Species:	Anopheles gambiae

Alignment Length:	568	Identity:	202/568 - (35%)
Similarity:	294/568 - (51%)	Gaps:	41/568 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   534 SGGGSGPGSHGGQPHHQKPRRTASQRIRAATAARKL----HFVF--------------DPAGRLC 580
            |...|.|.:......|...:||.........:|.:.    |::|              ||.|:..
Mosquito   282 SSSASAPSTAPSMQKHSVNQRTIQNSALTLQSATETPGCSHYLFCPIFCCGGRSDNVLDPQGKFY 346

  Fly   581 YYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILF-HFRTGYLEDGVL 644
            ..|..:||::||||.|||..|.:|..........|..:|..:|.:||:|||| ..|..||.:|..
Mosquito   347 IAWLFIVSLSFLYNAWVIPLRSSFPYQTPENTKYWIAMDICADVIYLLDILFVKHRLMYLYEGFW 411

  Fly   645 QTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFNSIL-RSFRLVKIYRFWAFMDRTERHTNY 708
            ..|....|.:||....|.:|.|.|:|||.|||..|...:: |:.||:||..||.|....:|..:.
Mosquito   412 VKDKNLTRKNYMRKLQFKMDLLALVPLDLLYLRFGTEHVVFRAPRLLKIQSFWEFFKLIDRVISS 476

  Fly   709 PNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWVYHDSESADVVKQYLQSYYWCTLALTT 773
            |::.|....:.|:|.:.|...|.|:......|.||..||:::...|     |::.:.:.|...|:
Mosquito   477 PHIIRVVKTLTYMLYMIHLTACAYYAYSAYQGLGSNRWVFNNKGHA-----YVRCFAFATKTATS 536

  Fly   774 IGDLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVP 838
            ||..|||..:||.:|:....|.|:.:||.::|.:.:|:.:.:.::.|::..:|....|||...:|
Mosquito   537 IGKNPKPEKEGELMFMTAAWLMGVFVFALLIGQIRDIIATATRSKSEYKQLVDETLEYMRRLNLP 601

  Fly   839 NHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELV 903
            ..||.:|..||.:.|..|||.||...:..||..||.:|||:||:.||.:|::|.:.|...|.|||
Mosquito   602 TDLQRRVKMWFTFTWEQQKCLDETHIMDALPANLKTDIAISVHIQTLSKVQLFADCEEALLRELV 666

  Fly   904 LRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVV-ADNGKTVMASLKAGSYFGEISILNM-GTA 966
            |:||.|.|.|||::|||||||||||||..|::||: ......|:|:|..||.|||||:|.: |..
Mosquito   667 LKLRSVTFLPGDFVCRKGEVGKEMYIVKTGQVQVMGGPRNDVVLATLYEGSVFGEISLLAINGAE 731

  Fly   967 GNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAPLEKVKYFNVVAM 1031
            ||||||.|||.|:|:||||||.|:.:.:..||.|:..|:..| |.|.: |.|..||.:
Mosquito   732 GNRRTADVRSKGFSNLFVLSKSDLNEAIVYYPNAQAILKKRA-KSLMR-KNAAREKAE------- 787

  Fly  1032 GRCQSTPGLVESCGRTSLEEMWLPPATAGASSLMHHHQALQQQHQASQ 1079
                 :...:::.|......:..||..|....|....|||.|:..|.|
Mosquito   788 -----SQQSIDTKGSEVDVVIRNPPDPASPKLLKTVIQALPQESAAVQ 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	79/239 (33%)
		CAP_ED	890..1004	CDD:237999	63/115 (55%)
		DUF4655	1084..>1154	CDD:317882
AgaP_AGAP011459	XP_554755.3	Ion_trans	366..582	CDD:278921	69/220 (31%)
		Crp	647..>769	CDD:223736	66/121 (55%)
		CAP_ED	653..769	CDD:237999	63/115 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920