back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42260 and Kcnh3

DIOPT Version :10

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_058804.1	Gene:	Kcnh3 / 27150	RGDID:	71070	Length:	1087	Species:	Rattus norvegicus

Alignment Length:	907	Identity:	185/907 - (20%)
Similarity:	332/907 - (36%)	Gaps:	243/907 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   429 NRSTGRGSQDNTLAGGGATSLAMGGHNQYGGNYCNGTDRYPRSRSQQQGHHNAAQQAHHPYQLQH 493
            :.:..||..||....|       ||..:||             |:..:|.:  |.:......|.|
  Rat   134 SETKNRGGPDNWKERG-------GGRRRYG-------------RAGSKGFN--ANRRRSRAVLYH 176

  Fly   494 SASTVSHHPHAHGPPSQGGPGGPGPPHGGHPHHPHHGGAGSGGGSGPGSHGGQPHHQKPRRTASQ 558
            .:..:...|......::|       ..|..|:.|.:
  Rat   177 LSGHLQKQPKGKHKLNKG-------VFGEKPNLPEY----------------------------- 205

  Fly   559 RIRAATAARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIW---FCLDY 620
               ...|.||..|:....|.|...|...:.:|.||....:.|..........:.|..   .| |.
  Rat   206 ---KVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVC-DL 266

  Fly   621 LSDFLYLIDILFHFRTGYL-EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLY-----LSIG 679
            ..:.|:::||:.:|||.:: :.|.:......:..||: :|.|.:|.:..||.|.|:     :.:|
  Rat   267 AVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYV-TTWFLLDVIAALPFDLLHAFKVNVYVG 330

  Fly   680 FNSILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCLYHIIHKNNG 740
            .: :|::.||:::.|   .:.|.:|::.|     |..::..|:.:|    ||..|::..|.:...
  Rat   331 AH-LLKTVRLLRLLR---LLPRLDRYSQY-----SAVVLTLLMAVFALLAHWVACVWFYIGQQEI 386

  Fly   741 FGSRN------WV-----------YHDSESAD--------------------------------V 756
            ..|.:      |:           |..|.|.|                                :
  Rat   387 ENSESELPEIGWLQELARRLETPYYLVSRSPDGGNSSGQSENCSSSGGGSEANGTGLELLGGPSL 451

  Fly   757 VKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKE 820
            ...|:.|.|:...:||::| ......:..|.:|.|..:|.|.::.|.|.|:|..|:..:.|.|..
  Rat   452 RSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFL 516

  Fly   821 FQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTL 885
            :.::...::.|:|:.|:|..|:.:::::|...|......|....:..|||:|:|:||:::|.:.|
  Rat   517 YHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVL 581

  Fly   886 KRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLK 950
             ::.:|:....|.|..|.|.|||...:||:|:..:|:..:.:|.|..|.::|:  .|.||:|.|.
  Rat   582 -QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVL--KGGTVLAILG 643

  Fly   951 AGSYFG-EISILNMGTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEK 1014
            .|...| |:.........|   |.|:.:.|..|..|....:.:.|..||.        ...|..:
  Rat   644 KGDLIGCELPQREQVVKAN---ADVKGLTYCVLQCLQLAGLHESLALYPE--------FAPRFSR 697

  Fly  1015 YKKAPLEKVKYFNVVAMGRCQSTPGLVESCGRTSLEEMWLPPATAGASSLMHHHQALQQQHQASQ 1079
            ..:..|.    :|:.|.|        |.:...||        :.:|.::||   ..|:::....:
  Rat   698 GLRGELS----YNLGAGG--------VSAEVDTS--------SLSGDNTLM---STLEEKETDGE 739

  Fly  1080 Q----QPHRQESTQTSSQTHGYSPRSYADRLARATDSPRSVSPSAHGSEERP----RSRTTSHHS 1136
            |    .|...:...:...:.|.:..|.|.:|.    |||..:|       ||    |.|.:....
  Rat   740 QGHTISPAPADEPSSPLLSPGCTSSSSAAKLL----SPRRTAP-------RPRLGGRGRPSRAGV 793

  Fly  1137 IRPQSQPSHTGHICD--------------------------------------SSSQLECYGAGV 1163
            ::|::.||......|                                      ..|..||..:..
  Rat   794 LKPEAGPSAHPRTLDGLQLPPMPWNVPPDLSPRVVDGIEDGCGSDQHKFSFRVGQSGPECSSSPS 858

  Fly  1164 GGAGGG--TTPLLGSHEVLEDEIKRLRERLHTVESENQALNTKLSQQQWDLENRLAEIEMQI 1223
            .|...|  |.||:.|.....|.:.:||:.:           |:||:|...:...|..:...:
  Rat   859 PGTESGLLTVPLVPSEARNTDTLDKLRQAV-----------TELSEQVLQMREGLQSLRQAV 909

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.