DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42260 and KCNH5

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_647479.2	Gene:	KCNH5 / 27133	HGNCID:	6254	Length:	988	Species:	Homo sapiens

Alignment Length:	801	Identity:	172/801 - (21%)
Similarity:	311/801 - (38%)	Gaps:	185/801 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   569 LHFVFDPAGRLCYY---WSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDI 630
            ||:        |.:   |..|:.:...|...::.|..:| :..:..|| |..||.:.|.::|:||
Human   208 LHY--------CAFKTTWDWVILILTFYTAIMVPYNVSF-KTKQNNIA-WLVLDSVVDVIFLVDI 262

  Fly   631 LFHFRTGYL-EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLD----FLYLSIGFNSILRSFRLV 690
            :.:|.|.:: ..|.:.:|...:|.:|: .|.|.||.|..||.|    |..:..|.:|:..|.::|
Human   263 VLNFHTTFVGPGGEVISDPKLIRMNYL-KTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVV 326

  Fly   691 KIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCL------YHIIHK-NNGFGSR 744
            ::.|......:.:.:..|     ..|::..|:.:|    ||..|:      |.:|.: .|.....
Human   327 RLLRLGRVARKLDHYLEY-----GAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQID 386

  Fly   745 NWVY-------------------HDSESADVVKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFV 789
            :|:|                   ....|.|.:  |:.|.|:...:||||| ....|.:..|.:|.
Human   387 SWLYQLALSIGTPYRYNTSAGIWEGGPSKDSL--YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFS 449

  Fly   790 ILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWL 854
            :..::.|.:|:||:.|:|..|...:.|....:...|:.|:.::::.:||..|..:|:.:....|.
Human   450 VAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWS 514

  Fly   855 TQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICR 919
            ..|..|.|:.:|..|..::|:|.::::.........|:....|.|..|.:..:.:..:|||.|..
Human   515 MSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYH 579

  Fly   920 KGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFV 984
            .||....:..|..|.|:|:.|:  .|:|.|..|..||:|.......|  ...|:||::.|.||.:
Human   580 AGESVDALCFVVSGSLEVIQDD--EVVAILGKGDVFGDIFWKETTLA--HACANVRALTYCDLHI 640

  Fly   985 LSKKDMWDVLKEYPA------------ARVRLESIAVKRLEKYKKAPLEKVKYFNVVAM------ 1031
            :.::.:..||..|.|            ..:| :.|..:::...||...|:::..|.|.:
Human   641 IKREALLKVLDFYTAFANSFSRNLTLTCNLR-KRIIFRKISDVKKEEEERLRQKNEVTLSIPVDH 704

  Fly  1032 ------------------GRCQSTP----------GLVESCGRTSLEEMWLPPATAGASSLMH-- 1066
                              |..|..|          .|......|....:.:...|...:||.:
Human   705 PVRKLFQKFKQQKELRNQGSTQGDPERNQLQVESRSLQNGASITGTSVVTVSQITPIQTSLAYVK 769

  Fly  1067 HHQALQQQHQASQQQPHRQESTQTSSQTHGYSPRSYADRLARATDSPRSV-------------SP 1118
            ..::|:|.::.:.:                ..|...||:.....:||..:             :.
Human   770 TSESLKQNNRDAME----------------LKPNGGADQKCLKVNSPIRMKNGNGKGWLRLKNNM 818

  Fly  1119 SAHGSEERPRSRTTSHHSI-----RPQSQPSHTG---------HICDS---SSQLECYGAGVGGA 1166
            .||..::...:..|...|:     .|:|..|...         ..|||   .|.|.     :..|
Human   819 GAHEEKKEDWNNVTKAESMGLLSEDPKSSDSENSVTKNPLRKTDSCDSGITKSDLR-----LDKA 878

  Fly  1167 GGGTTPLLGSHEVLEDEIKR-------------LRERLHTVESENQALNTKLSQQQWDLENRLAE 1218
            |...:||  .|..::.:.|.             |:|..|.::.:.|.|:.:::.    ||.::||
Human   879 GEARSPL--EHSPIQADAKHPFYPIPEQALQTTLQEVKHELKEDIQLLSCRMTA----LEKQVAE 937

  Fly  1219 I-----EMQICGVSSTSSVDP 1234
            |     |..:...||..|..|
Human   938 ILKILSEKSVPQASSPKSQMP 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	67/276 (24%)
		CAP_ED	890..1004	CDD:237999	33/125 (26%)
		DUF4655	1084..>1154	CDD:317882	15/99 (15%)
KCNH5	NP_647479.2	PAS_9	39..132	CDD:404329
		PLN03192	217..>616	CDD:215625	102/410 (25%)
		Selectivity filter. /evidence=ECO:0000250	432..437		3/4 (75%)
		Crp	544..725	CDD:223736	41/185 (22%)
		Calmodulin-binding. /evidence=ECO:0000255	704..715		0/10 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	717..742		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	838..890		13/58 (22%)
		CAD (involved in subunit assembly). /evidence=ECO:0000250	909..948		11/42 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	969..988
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910