DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42260 and Kcnh8

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_659563.1	Gene:	Kcnh8 / 246325	RGDID:	2549	Length:	1102	Species:	Rattus norvegicus

Alignment Length:	794	Identity:	179/794 - (22%)
Similarity:	320/794 - (40%)	Gaps:	168/794 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   569 LHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAF------QEINRRTIAIWFCLDYLSDFLYL 627
            |||....||     |..::.:|..|....:.|...|      ......|::     |...:.|::
  Rat   215 LHFSTFKAG-----WDWLILLATFYVAVTVPYNVCFIGNEDLSTTRSTTVS-----DIAVEILFI 269

  Fly   628 IDILFHFRTGYL-EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFN-------SIL 684
            |||:.:|||.|: :.|.:..:|..:..||: :|.|.||.:..||.|.||   .||       .:|
  Rat   270 IDIILNFRTTYVSKSGQVIFEARSICIHYV-TTWFIIDLIAALPFDLLY---AFNVTVVSLVHLL 330

  Fly   685 RSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCLYHIIHK-------- 737
            ::.||:::.|....:||..:|        ||.::..|:.:|    ||..|::::|.|
  Rat   331 KTVRLLRLLRLLQKLDRYSQH--------STIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSL 387

  Fly   738 ---------------------NNGFGSRNWVYHDSESADVVKQYLQSYYWCTLALTTIG-DLPKP 780
                                 ||..|          ...:...|:.:.|:...:||::| .....
  Rat   388 LKWEVGWLHELGKRLESPYYGNNTLG----------GPSIRSAYIAALYFTLSSLTSVGFGNVSA 442

  Fly   781 RSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKV 845
            .:..|.:|.|..:|.|.::.|.|.|:|..|:..:.:....:..:...:|.::|:..:|..|:.::
  Rat   443 NTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRM 507

  Fly   846 IKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVL 910
            :::|...|......|....:...||:|:::|.::::.:.| ::.:|:....|.|..|.|.::...
  Rat   508 LEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSF 571

  Fly   911 FSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFG-EISILNMGTAGNRRTASV 974
            .:||:|:.|:|:..:.:|.|..|.::|:.|:  .|:|.|..|...| .:||.:.....|   |.|
  Rat   572 CAPGEYLLRQGDALQAIYFVCSGSMEVLKDS--MVLAILGKGDLIGANLSIKDQVIKTN---ADV 631

  Fly   975 RSVGYSDLFVLSKKDMWDVLKEYPA----------------ARVRLESIAVKRLEKYKKAPLEKV 1023
            :::.|.||..:..|.:::||..||.                .|...||..:.||......|..:.
  Rat   632 KALTYCDLQCIILKGLFEVLGLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSTVPQAEP 696

  Fly  1024 KYFNVVAMGRCQSTPGLVESCGRTSLEE---MWLPPATAGASSLMHHHQALQQQHQASQQQPHRQ 1085
            |....:.    :..|.:||......:||   ..|.|.....||:.|
  Rat   697 KGNGSIK----KRLPSIVEDEEEEEVEEEETTSLSPIYTRGSSVSH------------------- 738

  Fly  1086 ESTQTSSQ-----------THGYSPRSYADRLARATDSPRS---VSPSAHGSEERPRSRT---TS 1133
             |.:|.|.           |.|..|.....|::.| :||::   ..|..||:.:....:.   :.
  Rat   739 -SKKTGSSKSYLGLSLKQLTSGTVPFHSPIRVSSA-NSPKTKQEADPPNHGTRKEKNLKVQLCSL 801

  Fly  1134 HHSIRPQSQPSHTGHICDSSSQLEC----YGAGVGGAGGGTTPLLGSHEV----LEDEIKRLRER 1190
            ..:..|:..|.....|.|.:|..|.    :|:.........:|.||..|:    |..:.:..:::
  Rat   802 GTAGTPELSPRIVDGIEDGNSSEETQTFDFGSEQIRPEPRISPSLGESEIGAAFLFIKAEETKQQ 866

  Fly  1191 LHTVESENQALNTKLSQQQWD-------LENRLA-EIEMQICGVSSTSSVDPENETEELERNRES 1247
            ::.:.||...|..::||...|       |||.|: :...|.|.:..| |:.|..|:.:   .|.|
  Rat   867 INKLNSEVTTLTQEVSQLGKDMRSIMQLLENILSPQQPSQFCSLHPT-SICPSRESFQ---TRVS 927

  Fly  1248 IIXHGSVLPHQAIG 1261
            .. |...|..||.|
  Rat   928 WSAHQPCLHLQANG 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	64/285 (22%)
		CAP_ED	890..1004	CDD:237999	34/130 (26%)
		DUF4655	1084..>1154	CDD:317882	17/86 (20%)
Kcnh8	NP_659563.1	PAS_9	29..135	CDD:290162
		PAS	42..133	CDD:238075
		Ion_trans	239..481	CDD:278921	61/268 (23%)
		Ion_trans_2	<421..475	CDD:285168	15/53 (28%)
		Selectivity filter. /evidence=ECO:0000250	434..439		1/4 (25%)
		Crp	548..707	CDD:223736	40/167 (24%)
		CAP_ED	551..662	CDD:237999	33/115 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	683..744		16/84 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..793		8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..845		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	960..983
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910