DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and Kcnh5

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_766393.2	Gene:	Kcnh5 / 238271	MGIID:	3584508	Length:	988	Species:	Mus musculus

Alignment Length:	800	Identity:	169/800 - (21%)
Similarity:	310/800 - (38%)	Gaps:	184/800 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   569 LHFVFDPAGRLCYY---WSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDI 630
            ||:        |.:   |..|:.:...|...::.|..:| :..:..|| |..||.:.|.::|:||
Mouse   208 LHY--------CAFKTTWDWVILILTFYTAIMVPYNVSF-KTKQNNIA-WLVLDSVVDVIFLVDI 262

  Fly   631 LFHFRTGYL-EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLD----FLYLSIGFNSILRSFRLV 690
            :.:|.|.:: ..|.:.:|...:|.:|: .|.|.||.|..||.|    |..:..|.:|:..|.::|
Mouse   263 VLNFHTTFVGPGGEVISDPKLIRMNYL-KTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVV 326

  Fly   691 KIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCL------YHIIHK-NNGFGSR 744
            ::.|......:.:.:..|     ..|::..|:.:|    ||..|:      |.:|.: .|.....
Mouse   327 RLLRLGRVARKLDHYLEY-----GAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQID 386

  Fly   745 NWVY-------------------HDSESADVVKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFV 789
            :|:|                   ....|.|.:  |:.|.|:...:||||| ....|.:..|.:|.
Mouse   387 SWLYQLALSIGTPYRYNTSAGIWEGGPSKDSL--YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFS 449

  Fly   790 ILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWL 854
            :..::.|.:|:||:.|:|..|...:.|....:...|:.|:.::::.:||..|..:|:.:....|.
Mouse   450 VAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWS 514

  Fly   855 TQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICR 919
            ..|..|.|:.:|..|..::|:|.::::.........|:....|.|..|.:..:.:..:|||.|..
Mouse   515 MSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYH 579

  Fly   920 KGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFV 984
            .||....:..|..|.|:|:.|  :.|:|.|..|..||:|.......|  ...|:||::.|.||.:
Mouse   580 AGESVDALCFVVSGSLEVIQD--EEVVAILGKGDVFGDIFWKETTLA--HACANVRALTYCDLHI 640

  Fly   985 LSKKDMWDVLKEYPA------------ARVRLESIAVKRLEKYKKAPLEKVKYFNVVAM------ 1031
            :.::.:..||..|.|            ..:| :.|..:::...||...|:::..|.|.:
Mouse   641 IKREALLKVLDFYTAFANSFSRNLTLTCNLR-KRIIFRKISDVKKEEEERLRQKNEVTLSIPVDH 704

  Fly  1032 ------------------GRCQSTPG----LVES---------CGRTSLEEMWLPPATAGASSLM 1065
                              |..||.|.    .|||         .|.:.:....:.|.....:.:.
Mouse   705 PVRKLFQKFKQQKELRIQGSAQSDPERSQLQVESRPLQNGASITGTSVVTVSQITPIQTSLAYVK 769

  Fly  1066 HHHQALQQQHQASQQQPH---------------------------RQESTQTSSQTHGYSPRSYA 1103
            ......|....|.:.:|:                           :........:...::..:.|
Mouse   770 TSESLKQNNRDAMELKPNGGAEPKCLKVNSPIRMKNGNGKGWLRLKNNMGAQEEKKEDWNNVTKA 834

  Fly  1104 DRLARATDSPRSVSPSAHGSEERPRSRTTSHHSIRPQSQPSHTGHICDS---SSQLECYGAGVGG 1165
            :.:...::.|:. |.|.:...:.|..:|.|                |||   .|.|.     :..
Mouse   835 ESMGLLSEDPKG-SDSENSVTKNPLRKTDS----------------CDSGITKSDLR-----LDK 877

  Fly  1166 AGGGTTPLLGSHEVLEDEIKR-------------LRERLHTVESENQALNTKLSQQQWDLENRLA 1217
            ||...:||  .|...:.::|.             |:|..|.::.:.|.|:.:::.    ||.::|
Mouse   878 AGEARSPL--EHSPSQADVKHSFYPIPEQALQTTLQEVKHELKEDIQLLSCRMTA----LEKQVA 936

  Fly  1218 EIEMQIC--GVSSTSSVDPE 1235
            ||...:.  .|..|||..|:
Mouse   937 EILKLLSEKSVPQTSSPKPQ 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	67/276 (24%)
		CAP_ED	890..1004	CDD:237999	33/125 (26%)
		DUF4655	1084..>1154	CDD:317882	10/72 (14%)
Kcnh5	NP_766393.2	PAS	37..131	CDD:238075
		PAS_3	40..127	CDD:285623
		Ion_trans	232..479	CDD:278921	64/256 (25%)
		Ion_trans_2	<419..473	CDD:285168	18/53 (34%)
		Selectivity filter. /evidence=ECO:0000250	432..437		3/4 (75%)
		Crp	544..723	CDD:223736	40/183 (22%)
		CAP_ED	550..660	CDD:237999	33/113 (29%)
		Calmodulin-binding. /evidence=ECO:0000255	704..715		0/10 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	721..741		7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	838..893		16/78 (21%)
		CAD (involved in subunit assembly). /evidence=ECO:0000250	909..948		10/42 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910