DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42260 and Kcnh5

DIOPT Version :9

Sequence 1:NP_001356969.1 Gene:CG42260 / 37614 FlyBaseID:FBgn0259145 Length:1269 Species:Drosophila melanogaster
Sequence 2:NP_766393.2 Gene:Kcnh5 / 238271 MGIID:3584508 Length:988 Species:Mus musculus


Alignment Length:800 Identity:169/800 - (21%)
Similarity:310/800 - (38%) Gaps:184/800 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   569 LHFVFDPAGRLCYY---WSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDI 630
            ||:        |.:   |..|:.:...|...::.|..:| :..:..|| |..||.:.|.::|:||
Mouse   208 LHY--------CAFKTTWDWVILILTFYTAIMVPYNVSF-KTKQNNIA-WLVLDSVVDVIFLVDI 262

  Fly   631 LFHFRTGYL-EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLD----FLYLSIGFNSILRSFRLV 690
            :.:|.|.:: ..|.:.:|...:|.:|: .|.|.||.|..||.|    |..:..|.:|:..|.::|
Mouse   263 VLNFHTTFVGPGGEVISDPKLIRMNYL-KTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVV 326

  Fly   691 KIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCL------YHIIHK-NNGFGSR 744
            ::.|......:.:.:..|     ..|::..|:.:|    ||..|:      |.:|.: .|.....
Mouse   327 RLLRLGRVARKLDHYLEY-----GAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQID 386

  Fly   745 NWVY-------------------HDSESADVVKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFV 789
            :|:|                   ....|.|.:  |:.|.|:...:||||| ....|.:..|.:|.
Mouse   387 SWLYQLALSIGTPYRYNTSAGIWEGGPSKDSL--YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFS 449

  Fly   790 ILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWL 854
            :..::.|.:|:||:.|:|..|...:.|....:...|:.|:.::::.:||..|..:|:.:....|.
Mouse   450 VAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWS 514

  Fly   855 TQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICR 919
            ..|..|.|:.:|..|..::|:|.::::.........|:....|.|..|.:..:.:..:|||.|..
Mouse   515 MSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYH 579

  Fly   920 KGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFV 984
            .||....:..|..|.|:|:.|  :.|:|.|..|..||:|.......|  ...|:||::.|.||.:
Mouse   580 AGESVDALCFVVSGSLEVIQD--EEVVAILGKGDVFGDIFWKETTLA--HACANVRALTYCDLHI 640

  Fly   985 LSKKDMWDVLKEYPA------------ARVRLESIAVKRLEKYKKAPLEKVKYFNVVAM------ 1031
            :.::.:..||..|.|            ..:| :.|..:::...||...|:::..|.|.:      
Mouse   641 IKREALLKVLDFYTAFANSFSRNLTLTCNLR-KRIIFRKISDVKKEEEERLRQKNEVTLSIPVDH 704

  Fly  1032 ------------------GRCQSTPG----LVES---------CGRTSLEEMWLPPATAGASSLM 1065
                              |..||.|.    .|||         .|.:.:....:.|.....:.:.
Mouse   705 PVRKLFQKFKQQKELRIQGSAQSDPERSQLQVESRPLQNGASITGTSVVTVSQITPIQTSLAYVK 769

  Fly  1066 HHHQALQQQHQASQQQPH---------------------------RQESTQTSSQTHGYSPRSYA 1103
            ......|....|.:.:|:                           :........:...::..:.|
Mouse   770 TSESLKQNNRDAMELKPNGGAEPKCLKVNSPIRMKNGNGKGWLRLKNNMGAQEEKKEDWNNVTKA 834

  Fly  1104 DRLARATDSPRSVSPSAHGSEERPRSRTTSHHSIRPQSQPSHTGHICDS---SSQLECYGAGVGG 1165
            :.:...::.|:. |.|.:...:.|..:|.|                |||   .|.|.     :..
Mouse   835 ESMGLLSEDPKG-SDSENSVTKNPLRKTDS----------------CDSGITKSDLR-----LDK 877

  Fly  1166 AGGGTTPLLGSHEVLEDEIKR-------------LRERLHTVESENQALNTKLSQQQWDLENRLA 1217
            ||...:||  .|...:.::|.             |:|..|.::.:.|.|:.:::.    ||.::|
Mouse   878 AGEARSPL--EHSPSQADVKHSFYPIPEQALQTTLQEVKHELKEDIQLLSCRMTA----LEKQVA 936

  Fly  1218 EIEMQIC--GVSSTSSVDPE 1235
            ||...:.  .|..|||..|:
Mouse   937 EILKLLSEKSVPQTSSPKPQ 956

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42260NP_001356969.1 Ion_trans 581..819 CDD:334124 67/276 (24%)
CAP_ED 890..1004 CDD:237999 33/125 (26%)
DUF4655 1084..>1154 CDD:317882 10/72 (14%)
Kcnh5NP_766393.2 PAS 37..131 CDD:238075
PAS_3 40..127 CDD:285623
Ion_trans 232..479 CDD:278921 64/256 (25%)
Ion_trans_2 <419..473 CDD:285168 18/53 (34%)
Selectivity filter. /evidence=ECO:0000250 432..437 3/4 (75%)
Crp 544..723 CDD:223736 40/183 (22%)
CAP_ED 550..660 CDD:237999 33/113 (29%)
Calmodulin-binding. /evidence=ECO:0000255 704..715 0/10 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 721..741 7/19 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 838..893 16/78 (21%)
CAD (involved in subunit assembly). /evidence=ECO:0000250 909..948 10/42 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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