Protein Alignment CG42260 and Kcnh5

DIOPT Version :10

• Sequence 1: NP_001356969.1
• Gene: CG42260 / 37614
• FlyBaseID: FBgn0259145
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: NP_766393.2
• Gene: Kcnh5 / 238271
• MGIID: 3584508
• Length: 988
• Species: Mus musculus
• Alignment Length: 800
• Identity: 169/800 - (21%)
• Similarity: 310/800 - (38%)
• Gaps: 184/800 - (23%)

  Fly   569 LHFVFDPAGRLCYY---WSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDI 630
            ||:        |.:   |..|:.:...|...::.|..:| :..:..|| |..||.:.|.::|:||
Mouse   208 LHY--------CAFKTTWDWVILILTFYTAIMVPYNVSF-KTKQNNIA-WLVLDSVVDVIFLVDI 262

  Fly   631 LFHFRTGYL-EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLD----FLYLSIGFNSILRSFRLV 690
            :.:|.|.:: ..|.:.:|...:|.:|: .|.|.||.|..||.|    |..:..|.:|:..|.::|
Mouse   263 VLNFHTTFVGPGGEVISDPKLIRMNYL-KTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVV 326

  Fly   691 KIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCL------YHIIHK-NNGFGSR 744
            ::.|......:.:.:..|     ..|::..|:.:|    ||..|:      |.:|.: .|.....
Mouse   327 RLLRLGRVARKLDHYLEY-----GAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQID 386

  Fly   745 NWVY-------------------HDSESADVVKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFV 789
            :|:|                   ....|.|.:  |:.|.|:...:||||| ....|.:..|.:|.
Mouse   387 SWLYQLALSIGTPYRYNTSAGIWEGGPSKDSL--YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFS 449

  Fly   790 ILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWL 854
            :..::.|.:|:||:.|:|..|...:.|....:...|:.|:.::::.:||..|..:|:.:....|.
Mouse   450 VAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWS 514

  Fly   855 TQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICR 919
            ..|..|.|:.:|..|..::|:|.::::.........|:....|.|..|.:..:.:..:|||.|..
Mouse   515 MSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYH 579

  Fly   920 KGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFV 984
            .||....:..|..|.|:|:.|  :.|:|.|..|..||:|.......|  ...|:||::.|.||.:
Mouse   580 AGESVDALCFVVSGSLEVIQD--EEVVAILGKGDVFGDIFWKETTLA--HACANVRALTYCDLHI 640

  Fly   985 LSKKDMWDVLKEYPA------------ARVRLESIAVKRLEKYKKAPLEKVKYFNVVAM------ 1031
            :.::.:..||..|.|            ..:| :.|..:::...||...|:::..|.|.:
Mouse   641 IKREALLKVLDFYTAFANSFSRNLTLTCNLR-KRIIFRKISDVKKEEEERLRQKNEVTLSIPVDH 704

  Fly  1032 ------------------GRCQSTPG----LVES---------CGRTSLEEMWLPPATAGASSLM 1065
                              |..||.|.    .|||         .|.:.:....:.|.....:.:.
Mouse   705 PVRKLFQKFKQQKELRIQGSAQSDPERSQLQVESRPLQNGASITGTSVVTVSQITPIQTSLAYVK 769

  Fly  1066 HHHQALQQQHQASQQQPH---------------------------RQESTQTSSQTHGYSPRSYA 1103
            ......|....|.:.:|:                           :........:...::..:.|
Mouse   770 TSESLKQNNRDAMELKPNGGAEPKCLKVNSPIRMKNGNGKGWLRLKNNMGAQEEKKEDWNNVTKA 834

  Fly  1104 DRLARATDSPRSVSPSAHGSEERPRSRTTSHHSIRPQSQPSHTGHICDS---SSQLECYGAGVGG 1165
            :.:...::.|:. |.|.:...:.|..:|.|                |||   .|.|.     :..
Mouse   835 ESMGLLSEDPKG-SDSENSVTKNPLRKTDS----------------CDSGITKSDLR-----LDK 877

  Fly  1166 AGGGTTPLLGSHEVLEDEIKR-------------LRERLHTVESENQALNTKLSQQQWDLENRLA 1217
            ||...:||  .|...:.::|.             |:|..|.::.:.|.|:.:::.    ||.::|
Mouse   878 AGEARSPL--EHSPSQADVKHSFYPIPEQALQTTLQEVKHELKEDIQLLSCRMTA----LEKQVA 936

  Fly  1218 EIEMQIC--GVSSTSSVDPE 1235
            ||...:.  .|..|||..|:
Mouse   937 EILKLLSEKSVPQTSSPKPQ 956

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..820	CDD:459842	67/277 (24%)
		CAP_ED	890..1004	CDD:237999	33/125 (26%)
Kcnh5	NP_766393.2	PAS_9	39..132	CDD:463873
		PLN03192	217..>616	CDD:215625	102/410 (25%)
		Selectivity filter. /evidence=ECO:0000250	432..437		3/4 (75%)
		Crp	551..758	CDD:440428	48/211 (23%)
		Calmodulin-binding. /evidence=ECO:0000255	704..715		0/10 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	721..741		7/19 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	838..893		16/78 (21%)
		CAD (involved in subunit assembly). /evidence=ECO:0000250	909..948		10/42 (24%)