Protein Alignment CG42260 and KCNH3

DIOPT Version :10

• Sequence 1: NP_001356969.1
• Gene: CG42260 / 37614
• FlyBaseID: FBgn0259145
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_011536387.1
• Gene: KCNH3 / 23416
• HGNCID: 6252
• Length: 1094
• Species: Homo sapiens
• Alignment Length: 883
• Identity: 183/883 - (20%)
• Similarity: 328/883 - (37%)
• Gaps: 216/883 - (24%)

  Fly   452 GGHNQY---GGNYCNGTDRYPRSRSQQQGHHNAAQQAHHPYQLQHSASTVSHHPHAHGPPSQGGP 513
            ||.:::   ||    |..||.|:||:....:....:|            |.:|...|....
Human   140 GGPDRWKETGG----GRRRYGRARSKGFNANRRRSRA------------VLYHLSGHLQKQ---- 184

  Fly   514 GGPGPPHGGHPHHPHHGGAGSGGGSGPGSHGGQPHHQKPRRTASQRIRAATAARKLHFVFDPAGR 578
                 |.|.|.             ...|..|.:|:..:.:         ..|.||..|:....|.
Human   185 -----PKGKHK-------------LNKGVFGEKPNLPEYK---------VAAIRKSPFILLHCGA 222

  Fly   579 LCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIW---FCLDYLSDFLYLIDILFHFRTGYL- 639
            |...|...:.:|.||....:.|..........:.|..   .| |...:.|:::||:.:|||.::
Human   223 LRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVC-DLAVEVLFILDIVLNFRTTFVS 286

  Fly   640 EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLY---LSIGFNS-ILRSFRLVKIYRFWAFMD 700
            :.|.:......:..||: :|.|.:|.:..||.|.|:   :::.|.: :|::.||:::.|   .:.
Human   287 KSGQVVFAPKSICLHYV-TTWFLLDVIAALPFDLLHAFKVNVYFGAHLLKTVRLLRLLR---LLP 347

  Fly   701 RTERHTNYPNLFRSTALIHYLLVIF----HWNGCL------------------------------ 731
            |.:|::.|     |..::..|:.:|    ||..|:
Human   348 RLDRYSQY-----SAVVLTLLMAVFALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLE 407

  Fly   732 --YHIIHK----NNGFGSRNWVYHDSES----------ADVVKQYLQSYYWCTLALTTIG-DLPK 779
              |:::.:    .|..|..:.....||:          ..:...|:.|.|:...:||::| ....
Human   408 TPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVS 472

  Fly   780 PRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVK 844
            ..:..|.:|.|..:|.|.::.|.|.|:|..|:..:.|.|..:.::...::.|:|:.|:|..|:.:
Human   473 ANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQR 537

  Fly   845 VIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPV 909
            ::::|...|......|....:..|||:|:|:||:::|.:.| ::.:|:....|.|..|.|.|||.
Human   538 MLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPA 601

  Fly   910 LFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFG-EISILNMGTAGNRRTAS 973
            ..:||:|:..:|:..:.:|.|..|.::|:  .|.||:|.|..|...| |:.........|   |.
Human   602 FCTPGEYLIHQGDALQALYFVCSGSMEVL--KGGTVLAILGKGDLIGCELPRREQVVKAN---AD 661

  Fly   974 VRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAPLEKVKYFNVVAMGRCQSTP 1038
            |:.:.|..|..|....:.|.|..||.        ...|..:..:..|.    :|:.|.|
Human   662 VKGLTYCVLQCLQLAGLHDSLALYPE--------FAPRFSRGLRGELS----YNLGAGG------ 708

  Fly  1039 GLVESCGRTSLEEMWLPPATAGASSLMHHHQALQQQHQASQQQPHRQESTQTSSQTHGYSPRSYA 1103
                  |...::...|    :|.::||   ..|:::....:|.|....:......:...||...:
Human   709 ------GSAEVDTSSL----SGDNTLM---STLEEKETDGEQGPTVSPAPADEPSSPLLSPGCTS 760

  Fly  1104 DRLARATDSPRSVSP-------------SAHGSEERPRSRTTSHHSIR---------PQSQPSHT 1146
            ...|....|||..:|             .|..:|..|.:...:...:|         |...|...
Human   761 SSSAAKLLSPRRTAPRPRLGGRGRPGRAGALKAEAGPSAPPRALEGLRLPPMPWNVPPDLSPRVV 825

  Fly  1147 GHI---CDS----------SSQLECYGAGVGGAGGGTTPLL------------GSHEVLE-DEIK 1185
            ..|   |.|          .|..||..:...|......|:|            |..|... |.:.
Human   826 DGIEDGCGSDQPKFSFRVGQSGPECSSSPSPGPAPADNPILLPTESGLLTVPHGPSEARNTDTLD 890

  Fly  1186 RLRERLHTVESENQALNTKLSQQQWDLENRLAEIEMQI 1223
            :||:.:           |:||:|...:...|..:...:
Human   891 KLRQAV-----------TELSEQVLQMREGLQSLRQAV 917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..820	CDD:459842	61/297 (21%)
		CAP_ED	890..1004	CDD:237999	34/114 (30%)
KCNH3	XP_011536387.1	PAS_9	40..135	CDD:463873
		PLN03192	227..>646	CDD:215625	100/431 (23%)
		cyc_nuc_ocin	<606..701	CDD:274839	26/107 (24%)