DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and Kcnh8

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_036016335.1	Gene:	Kcnh8 / 211468	MGIID:	2445160	Length:	1103	Species:	Mus musculus

Alignment Length:	793	Identity:	176/793 - (22%)
Similarity:	326/793 - (41%)	Gaps:	165/793 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   569 LHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAF------QEINRRTIAIWFCLDYLSDFLYL 627
            |||....||     |..::.:|..|....:.|...|      ......|::     |...:.|::
Mouse   215 LHFSTFKAG-----WDWLILLATFYVAVTVPYNVCFIGNEDLSTTRSTTVS-----DIAVEILFI 269

  Fly   628 I-DILFHFRTGYL-EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFN-------SI 683
            | ||:.:|||.|: :.|.:..:|..:..||: :|.|.||.:..||.|.||   .||       .:
Mouse   270 IADIILNFRTTYVSKSGQVIFEARSICIHYV-TTWFIIDLIAALPFDLLY---AFNVTVVSLVHL 330

  Fly   684 LRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCLYHIIHK------- 737
            |::.||:::.|....:||..:|        ||.::..|:.:|    ||..|::::|.|
Mouse   331 LKTVRLLRLLRLLQKLDRYSQH--------STIVLTLLMSMFALLAHWMACIWYVIGKMEREDNS 387

  Fly   738 ----------------------NNGFGSRNWVYHDSESADVVKQYLQSYYWCTLALTTIG-DLPK 779
                                  ||..|          ...:...|:.:.|:...:||::| ....
Mouse   388 LLKWEVGWLHELGKRLESPYYGNNTLG----------GPSIRSAYIAALYFTLSSLTSVGFGNVS 442

  Fly   780 PRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVK 844
            ..:..|.:|.|..:|.|.::.|.|.|:|..|:..:.:....:..:...:|.::|:..:|..|:.:
Mouse   443 ANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQR 507

  Fly   845 VIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPV 909
            ::::|...|......|....:...||:|:::|.::::.:.| ::.:|:....|.|..|.|.::..
Mouse   508 MLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTS 571

  Fly   910 LFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFG-EISILNMGTAGNRRTAS 973
            ..:||:|:.|:|:..:.:|.|..|.::|:.|:  .|:|.|..|...| .:||.:.....|   |.
Mouse   572 FCAPGEYLLRQGDALQAIYFVCSGSMEVLKDS--MVLAILGKGDLIGANLSIKDQVIKTN---AD 631

  Fly   974 VRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAPLEKVKY---FN-------- 1027
            |:::.|.||..:..|.:::||..||               :|....:|.:::   :|
Mouse   632 VKALTYCDLQCIILKGLFEVLGLYP---------------EYAHKFVEDIQHDLTYNLREGHESD 681

  Fly  1028 VVAMGRCQSTPGLVESCGRTSLEEMWLPPATAGASSLMHHHQALQQQHQASQQQPHRQESTQTSS 1092
            |::....:||....|..|..|:.:. ||.....     ...:.::::...|....:.:.|:.:.|
Mouse   682 VISRLSNKSTVSQAEPKGNGSINKR-LPSIVED-----EEEEEVEEEETTSLSPIYTRGSSVSHS 740

  Fly  1093 QTHGYSPRSY----ADRLARAT------------DSPRS---VSPSAHG--SEERPRSRTTSHHS 1136
            :..| |.::|    ..:||..|            :||::   ..|..||  .|:..:.:.:|..|
Mouse   741 KKTG-SNKTYLGLSLKQLASGTVPFHSPIRVSSANSPKTKQEADPPNHGRKKEKNLKVQLSSLGS 804

  Fly  1137 I-RPQSQPSHTGHICDSSSQLECYGAGVGGAGGGTTPLLGSHEVLEDEI---------KRLRERL 1191
            . .|:..|.....|.|.:|..|......|.......|.: |..:.|.||         :..::::
Mouse   805 AGTPELSPRIVDGIEDGNSNEETQTFDFGSEQIRPEPRI-SPPLAESEIGAAFLFIKAEETKQQI 868

  Fly  1192 HTVESENQALNTKLSQQQWD-------LENRLA-EIEMQICGVSSTSSVDPENETEELERNRESI 1248
            :.:.||...|..::||...|       |||.|: :...|.|.:..|    |...:.|..:.|.|.
Mouse   869 NKLNSEVTTLTQEVSQLGRDMRSIMQLLENILSPQQPSQFCSLHPT----PMCPSRESLQTRVSW 929

  Fly  1249 IXHGSVLPHQAIG 1261
            . |...|..||.|
Mouse   930 SAHQPCLHLQAGG 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	64/286 (22%)
		CAP_ED	890..1004	CDD:237999	33/114 (29%)
		DUF4655	1084..>1154	CDD:317882	20/91 (22%)
Kcnh8	XP_036016335.1	PAS_9	40..135	CDD:404329
		PLN03192	175..>616	CDD:215625	100/435 (23%)
		Crp	549..708	CDD:223736	42/179 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910