DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and cng-2

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_001343690.1	Gene:	cng-2 / 190732	WormBaseID:	WBGene00022295	Length:	819	Species:	Caenorhabditis elegans

Alignment Length:	725	Identity:	199/725 - (27%)
Similarity:	313/725 - (43%)	Gaps:	163/725 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   467 RYPRSRSQQQGHHNAAQQAHHPYQLQHSASTVSHHPHAHGPPSQGGPGGPGPPHGGHPHHP---- 527
            ||.|:.|.:.....|.:.:.....:..::.:|........|.|..|...|.|.....||.|
Worm    27 RYLRALSAKNQERTANEHSSVDVAVTQASLSVPRPGILRLPSSDPGEEDPQPSTSSIPHRPSKWA 91

  Fly   528 ----------------------HH---------------GGAGSGGGSGPGSH------------ 543
                                  ||               ..|.:||...||..
Worm    92 TVREKSPQIIGGHAKEVTFQERHHKLDLNKSRSTSKNRRKSAQNGGAEDPGQKSFSDVVKTAMML 156

  Fly   544 ----GGQPHHQK---PRRTASQRIRAATAA------------------------------RKLHF 571
                ....|.::   |.|.|:......|||                              |||::
Worm   157 RTWISAMEHDERESEPDRDATTTNAEITAADDRSILPSPPIFQQRQTGFTQIKDILTDKCRKLYY 221

  Fly   572 VF-DPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFR 635
            .: .......|||:.::|:..|||.:.::. |.|.:::......|..::...||.:|:|.|...|
Worm   222 FYVTENSTFFYYWTAIISIGILYNMFAMVI-FIFDDVHFGYFNQWLYVNLFFDFCFLLDCLVGSR 285

  Fly   636 TGYLEDG--VLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFN-SILRSFRLVKIYRFWA 697
            ..::.:|  |.|||  |:..:|..|....:|.|||.|.|| ||.|... |::|:.||||.||.:.
Worm   286 MTFVSEGNEVSQTD--KMFKNYRQSRRCKLDLLCLAPADF-YLFIDTKASLVRAIRLVKAYRLYE 347

  Fly   698 FMDRTERHTNYPNLFRSTALIHYLLVIFHWNGCLYHII--------HKNNGFG------------ 742
            |:..|:|.|::|:..:...|.....::||||.|:|.:.        ...|.||
Worm   348 FIMLTQRRTDFPHFMKILFLTSSCAILFHWNACVYFLFSLYQGLTEDDPNAFGFSYYKVFDPRFS 412

  Fly   743 ------SRNWVY-HDSESADV---------------------------VKQYLQSYYWCTLALTT 773
                  .::..| .|:|..|:                           .::|..:.||.:|.:|.
Worm   413 ICDALYDQDCYYPEDTEVLDIRDERPHYMEDMYKFWDKKFNILQIGNFSREYSMTIYWSSLTITK 477

  Fly   774 IGDLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVP 838
            .|..|.|....:....|...|.|:::|||::|.|.::||.:|....:|:..:||:|.||:.|.|.
Worm   478 CGQQPWPSKSSQNSLEIFDTLIGVLVFATIIGGVGSVVTQMSQNVNDFREMMDGIKFYMKYRGVQ 542

  Fly   839 NHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELV 903
            :.:|.:|:..|.||....:..|||..:|.||...:|.||.|:|.|||.:|.:|...:...|.|:|
Worm   543 SAIQDRVLNCFLYLNSHNQLYDEEEILSLLPPFFQARIAANLHQDTLSKVSLFYKCDQRLLQEVV 607

  Fly   904 LRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNM--GTA 966
            :.::..::||.||:|||.|..|||:||.:|.|.|:.|:....:.|||.|..|||:||:.:  ...
Worm   608 MLVKQQVYSPNDYLCRKNEKAKEMFIVKKGLLAVIDDDTGVELDSLKEGHTFGELSIVQVKGNIL 672

  Fly   967 GNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAPLEKVKYFNVVAM 1031
            |:||:.|:|||||||::||.:.|:..:|:|||..||||...|.:.|  :.:..||..:      :
Worm   673 GDRRSVSLRSVGYSDVYVLHQDDVTRLLQEYPEERVRLMENARRML--HSRGLLETNE------L 729

  Fly  1032 GR-CQSTPGL 1040
            |. |::..||
Worm   730 GEMCETDDGL 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	80/294 (27%)
		CAP_ED	890..1004	CDD:237999	50/115 (43%)
		DUF4655	1084..>1154	CDD:317882
cng-2	NP_001343690.1	Ion_trans	232..>407	CDD:366146	57/178 (32%)
		PLN03192	<457..>713	CDD:215625	99/255 (39%)
		CAP_ED	594..711	CDD:237999	51/116 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920