DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and cng-1

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_001122918.1	Gene:	cng-1 / 180004	WormBaseID:	WBGene00000562	Length:	661	Species:	Caenorhabditis elegans

Alignment Length:	516	Identity:	179/516 - (34%)
Similarity:	274/516 - (53%)	Gaps:	78/516 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   569 LHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEIN---RRTIAIWFCLDYLSDFLYLIDI 630
            :.|..|......|.|:.:||:..|:.. |......||:::   |.|..    |:.|.|.:.::|:
Worm    69 MSFTVDEHSNTFYLWTGLVSLVALHPL-VFTALSVFQDVHPFLRNTGP----LNLLLDLVNILDL 128

  Fly   631 LFHFRTGYLEDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFNSIL---RSFRLVKI 692
            :.|.|..|:|:||...:..||..|.:.||.|.:|.:.::|.:.|::   |....   |..||.|.
Worm   129 IAHTRIEYVENGVAVKNLSKLMHHRLKSTFFILDVIAVVPAESLHI---FGDSFFWSRINRLTKC 190

  Fly   693 YRFWAFMDRTERHTNYPNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGS---RNWVY------ 748
            ||.:.|..:|:..|..|:.|....||...:||||||||||..|.|...:.:   .:|::
Worm   191 YRLFDFSTQTDTRTTSPHAFGLFKLIFICVVIFHWNGCLYFYISKVYNYTTARLEHWIFSYDKII 255

  Fly   749 --------------------------HDSES----------------------ADVVKQYLQSYY 765
                                      |..|:                      |:..:||..|:|
Worm   256 NPILATCVTDIPNHRDFCDTDDLLITHLPENEVQFTVTDYMTTWENKTTTIKFANFFRQYALSFY 320

  Fly   766 WCTLALTTIGDLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKT 830
            |..|.|.|:|:.|.|.:..:..|.|...|.||::||.::|.|.|:|.:::..:.||:..|||.|.
Worm   321 WSALTLVTLGEQPSPCTTFQNAFEIGDTLLGLVIFAVIVGDVGNMVVAINLRKSEFENVLDGCKR 385

  Fly   831 YMRMRRVPNHLQVKVIKWFDYLWLTQKCS-DEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNT 894
            :|..|:|||.|:.|.:::|.|:|...... |||.....||.:|..|||:.:|:||||:|::|::.
Worm   386 FMVYRKVPNLLRKKAVEYFAYVWAHGGAQVDEEEIAEFLPPRLFGEIAVEIHMDTLKKVKLFESC 450

  Fly   895 EAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEIS 959
            :...|.||:|:|:..::||.||||:||:||.|||||..|.::||:::|:|:..:|.||..|||:|
Worm   451 DPRLLYELILKLQLRVYSPMDYICKKGDVGTEMYIVKEGFVEVVSEDGQTIFVTLPAGFVFGELS 515

  Fly   960 ILNMGTAGNR----RTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYK 1016
            |||:  .||:    |||||||.|||||:||.|:|:|:.|.|||.|:..|....::.|||.|
Worm   516 ILNI--PGNKNKNLRTASVRSKGYSDLYVLDKEDLWEALHEYPQAKDSLIQKGIQILEKDK 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	81/300 (27%)
		CAP_ED	890..1004	CDD:237999	60/117 (51%)
		DUF4655	1084..>1154	CDD:317882
cng-1	NP_001122918.1	PLN03192	153..>568	CDD:215625	150/419 (36%)
		CAP_ED	446..563	CDD:237999	60/118 (51%)
		CLZ	562..633	CDD:374604	5/13 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920