DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and egl-4

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_001294450.1	Gene:	egl-4 / 176991	WormBaseID:	WBGene00001173	Length:	783	Species:	Caenorhabditis elegans

Alignment Length:	669	Identity:	134/669 - (20%)
Similarity:	223/669 - (33%)	Gaps:	229/669 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   508 PSQGGPGGPGPPHGGHPHHPHHGGAGSGGGSGPGSHGG--QPHHQKPRRTASQ----RIRAATAA 566
            ||.||.||.|            |.:|..||..||..||  :....|.|:.:.|    :::..|..
Worm     7 PSSGGGGGGG------------GASGGAGGGAPGGGGGGIRGFFSKLRKPSDQPNGNQVQVGTRT 59

  Fly   567 RKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDIL 631
            .:.|.:                ...:......|.|...|...::||                 :.
Worm    60 FEAHEL----------------QKLIPQLEEAISRKDAQLRQQQTI-----------------VE 91

  Fly   632 FHF-RTGYLEDGV--LQTDALKL-----------------------RTHYMNSTIFYIDCLCLLP 670
            .|. |...||..|  ||.:..||                       ||..:.:.   :....:||
Worm    92 GHIKRISELEGEVTTLQRECDKLRSVLEQKAQSAASPGGQPPSPSPRTDQLGND---LQQKAVLP 153

  Fly   671 LDFLYLSIGFNSILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIFHWNGCLYHII 735
            .|         .:.|:.::..          :...||:.|  :...|.||
Worm   154 AD---------GVQRAKKIAV----------SAEPTNFEN--KPATLQHY--------------- 182

  Fly   736 HKNNGFGSRNWVYHDSESADVVKQYLQSYYWCTLALTTIGDLPKPRSK-----------GEYVFV 789
              |...|::..:....:..|.:||..:..     .:..:..:.:.|::           |:.:||
Worm   183 --NKTVGAKQMIRDAVQKNDFLKQLAKEQ-----IIELVNCMYEMRARAGQWVIQEGEPGDRLFV 240

  Fly   790 I----LQL-----LFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKV 845
            :    ||:     |.|.|...||:|.:|.:......|  ..||..|              :|:.|
Worm   241 VAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTA--SVQALTD--------------VQLWV 289

  Fly   846 IKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVL 910
            :....:..:||:...|..:..               ::.|.:|.||||.....:.::...:....
Worm   290 LDRSVFQMITQRLGMERHSQL---------------MNFLTKVSIFQNLSEDRISKMADVMDQDY 339

  Fly   911 FSPGDYICRKGE---VGKEMYIVNRGRLQVVAD-NGKT---VMASLKAGSYFGEISILNMGTAGN 968
            :..|.||.|:||   .|...:::|.|:::|... .|:|   .:..|..|.:|||.::|....
Worm   340 YDGGHYIIRQGEKCLQGDAFFVINSGQVKVTQQIEGETEPREIRVLNQGDFFGERALLGEEV--- 401

  Fly   969 RRTASV--------------RSVG--YSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRL----E 1013
             |||::              .|.|  ..||..| |||..|  ||..|..||.....||.:    |
Worm   402 -RTANIIAQAPGVEVLTLDRESFGKLIGDLESL-KKDYGD--KERLAQVVREPPSPVKIVDDFRE 462

  Fly  1014 KYKKAPLEKVKYFNVVAMGRCQSTPGLVESCGRTSLEEMWLPPATAGASSLMHHHQALQQQHQA- 1077
            ::.:..|:.||....:.:|          ..||..|      ....|..:.....:||:::|..
Worm   463 EFAQVTLKNVKRLATLGVG----------GFGRVEL------VCVNGDKAKTFALKALKKKHIVD 511

  Fly  1078 SQQQPH----RQESTQTSS 1092
            ::||.|    |....:||:
Worm   512 TRQQEHIFAERNIMMETST 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	45/283 (16%)
		CAP_ED	890..1004	CDD:237999	38/136 (28%)
		DUF4655	1084..>1154	CDD:317882	3/9 (33%)
egl-4	NP_001294450.1	Crp	195..>316	CDD:223736	26/156 (17%)
		CAP_ED	201..314	CDD:237999	24/148 (16%)
		Crp	313..>427	CDD:223736	29/117 (25%)
		CAP_ED	319..437	CDD:237999	32/122 (26%)
		PTZ00263	461..779	CDD:140289	18/86 (21%)
		STKc_cGK	478..739	CDD:270724	14/69 (20%)
		S_TK_X	734..783	CDD:214529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910