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Protein Alignment CG42260 and Kcnh3

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_006520546.1	Gene:	Kcnh3 / 16512	MGIID:	1341723	Length:	1101	Species:	Mus musculus

Alignment Length:	933	Identity:	199/933 - (21%)
Similarity:	332/933 - (35%)	Gaps:	245/933 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   429 NRSTGRGSQDN-------TLAGGGATSLAMGGHNQYGGNYCNGTDRYPRSRSQQQGHHNAAQQAH 486
            :.:..||..||       .|.|||.......|...:..|         |.||:
Mouse   134 SETKNRGGPDNWKEREPSFLVGGGRRRYGRAGSKGFNAN---------RRRSR------------ 177

  Fly   487 HPYQLQHSASTVSHHPHAHGPPSQGGPGGPGPPHGGHPHHPHHGGAGSGGGSGPGSHGGQPHHQK 551
                      .|.:|...|....         |.|.|.             ...|..|.:|:..:
Mouse   178 ----------AVLYHLSGHLQKQ---------PKGKHK-------------LNKGVFGEKPNLPE 210

  Fly   552 PRRTASQRIRAATAARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIW- 615
            .:         ..|.||..|:....|.|...|...:.:|.||....:.|..........:.|..
Mouse   211 YK---------VAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGP 266

  Fly   616 --FCLDYLSDFLYLIDILFHFRTGYL-EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLY-- 675
              .| |...:.|:::||:.:|||.:: :.|.:......:..||: :|.|.:|.:..||.|.|:
Mouse   267 PSVC-DLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYV-TTWFLLDVIAALPFDLLHAF 329

  Fly   676 ---LSIGFNSILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCL-- 731
               :.:|.: :|::.||:::.|   .:.|.:|::.|     |..::..|:.:|    ||..|:
Mouse   330 KVNVYVGAH-LLKTVRLLRLLR---LLPRLDRYSQY-----SAVVLTLLMAVFALLAHWVACVWF 385

  Fly   732 ------------------------------YHIIHK-----NNGFGSRNWVYHDSESA------- 754
                                          |:::.:     |:...|.|.....|.|.
Mouse   386 YIGQQEIESSESELPEIGWLQELARRLETPYYLVSRSPDGGNSSGQSENCSSSSSSSGSGGGRGS 450

  Fly   755 -------------DVVKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFVILQLLFGLMLFATVLG 805
                         .:...|:.|.|:...:||::| ......:..|.:|.|..:|.|.::.|.|.|
Mouse   451 EANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFG 515

  Fly   806 HVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPD 870
            :|..|:..:.|.|..:.::...::.|:|:.|:|..|:.:::::|...|......|....:..|||
Mouse   516 NVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPD 580

  Fly   871 KLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRL 935
            :|:|:||:::|.:.| ::.:|:....|.|..|.|.|||...:||:|:..:|:..:.:|.|..|.:
Mouse   581 ELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSM 644

  Fly   936 QVVADNGKTVMASLKAGSYFG-EISILNMGTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPA 999
            :|:  .|.||:|.|..|...| |:.........|   |.|:.:.|..|..|....:.:.|..||.
Mouse   645 EVL--KGGTVLAILGKGDLIGCELPQREQVVKAN---ADVKGLTYCVLQCLQLAGLHESLALYPE 704

  Fly  1000 ARVRLESIAVKRLEKYKKAPLEKVKYFNVVAMG-----RCQSTPGLVESCGRTSLEEMWLPPATA 1059
                    ...|..:..:..|.    :|:.|.|     ...|..|  ::...::|||    ..|.
Mouse   705 --------FAPRFSRGLRGELS----YNLGAGGVSAEVDTSSLSG--DNTLMSTLEE----KETD 751

  Fly  1060 GASSLMHHHQALQQQHQASQQQPHRQES-------TQTSSQTHGYSPRSYA--------DRLARA 1109
            |           :|.|..|........|       |.:||.....|||..|        .|.:||
Mouse   752 G-----------EQGHTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPSRA 805

  Fly  1110 TDSPRSVSPSAHGSEERPRS-----RTTSHHSIRPQSQPSHTGHI---CDS----------SSQL 1156
            ........||||     |||     ......::.|...|.....|   |.|          .|..
Mouse   806 GVLKPEAGPSAH-----PRSLDGLQLPPMPWNVPPDLSPRVVDGIEDGCSSDQPKFSFRVGQSGP 865

  Fly  1157 ECYGAGVGGAGGG--TTPLLGSHEVLEDEIKRLRERLHTVESENQALNTKLSQQQWDLENRLAEI 1219
            ||..:...|...|  |.||..|.....|.:.:||:.:           .:||:|...:...|..:
Mouse   866 ECSSSPSPGTESGLLTVPLGPSEARNTDTLDKLRQAV-----------MELSEQVLQMREGLQSL 919

  Fly  1220 E--MQICGVSSTSSVDPENETEE 1240
            .  :|:..|.......|....||
Mouse   920 RQAVQLILVPQGEGQCPRGSGEE 942

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.