DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42260 and Hcn3

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_032253.1	Gene:	Hcn3 / 15168	MGIID:	1298211	Length:	779	Species:	Mus musculus

Alignment Length:	777	Identity:	186/777 - (23%)
Similarity:	312/777 - (40%)	Gaps:	163/777 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   508 PSQGGPGGPGPPHGGHPHHPHHGGAGSGG--GSGP-----------------------GSHGGQP 547
            |:.|......|.....|..|....|.|||  .|.|                       |||
Mouse     7 PAAGAGEAATPARETPPAAPAQARAASGGVPESAPEPKRRQLGTLLQPTVNKFSLRVFGSH---- 67

  Fly   548 HHQKPRRTASQRIRAATAARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFA-FQEINRRT 611
               |......:|:::|.|     ::..|.....:||.:::.:..:.|..|:..... |:|.|...
Mouse    68 ---KAVEIEQERVKSAGA-----WIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPP 124

  Fly   612 IAIWFCLDYLSDFLYLIDILFHFRTG-YLEDG---VLQTDALKLRTHYMNSTIFYIDCLCLLPLD 672
               |...:.|||..:|:|::.:|||| .:|:|   :|...|  :||.|:. |.|.:|.:..:|:|
Mouse   125 ---WIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRA--IRTRYLR-TWFLVDLISSIPVD 183

  Fly   673 FLYL--------------------SIGFNSILRSFRLVKIYRFWAFMDRTER--HTNY---PNLF 712
            :::|                    .:.|..||...||:::.|...::.:.|.  |..|   ..:.
Mouse   184 YIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVV 248

  Fly   713 RSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWV-YHDSESADVVKQYLQSYYWCTLALTTIG- 775
            |...||..:|::.||:|||..::.....|.|..|| .:...:....:||..:.:.....:..||
Mouse   249 RIFNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVSMNRMVNHSWGRQYSHALFKAMSHMLCIGY 313

  Fly   776 DLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNH 840
            ....|....:....:|.::.|...:|..:||...::.|:.::|:::|.|...|:.||...::|..
Mouse   314 GQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPAD 378

  Fly   841 LQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLR 905
            .:.::.:::::.: ..|..|||..:..|.:.|:.||........:..:.:|.:.:..|:..::.:
Mouse   379 TRQRIHEYYEHRY-QGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTK 442

  Fly   906 LRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGNRR 970
            ||..:|.|||.:.|:|.||::||.:..|.|.|:|...:.  ..|..|||||||.:|..|    ||
Mouse   443 LRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARD--TRLTDGSYFGEICLLTRG----RR 501

  Fly   971 TASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAPLEKVKYFNVVAMGRCQ 1035
            |||||:..|..|:.||......||:|:|..|...|::|:.||.:..|..       :::...|.:
Mouse   502 TASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLRRIGKKN-------SILQRKRSE 559

  Fly  1036 STPGLVESCGRTSLEEMWLPPATAGASSLMHHHQALQQQHQASQQQPHRQESTQTSSQTHG---- 1096
            .:||                    .:..:|..|..   ||.....:..|..:..|.::..|
Mouse   560 PSPG--------------------SSGGVMEQHLV---QHDRDMARGVRGLAPGTGARLSGKPVL 601

  Fly  1097 YSPRSYADRLARATDS-----------PRSVSP---------SAHGSEERPRS------------ 1129
            :.|..:|...|.|..|           |..:||         ||..|...|.|
Mouse   602 WEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSARRSAGSPASPLVPVRAGPLLA 666

  Fly  1130 ----RTTSHHSIRPQSQPSHTGHICDS---SSQLECYGAGVGGA----GGGTTPLLGSHEVL 1180
                .:||    |..:.|:.|.|...|   .||:...|...||.    |....||..|...|
Mouse   667 RGPWASTS----RLPAPPARTLHASLSRTGRSQVSLLGPPPGGGARRLGPRGRPLSASQPSL 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	63/269 (23%)
		CAP_ED	890..1004	CDD:237999	44/113 (39%)
		DUF4655	1084..>1154	CDD:317882	23/112 (21%)
Hcn3	NP_032253.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		11/39 (28%)
		Involved in subunit assembly. /evidence=ECO:0000250	45..90		8/56 (14%)
		Ion_trans_N	48..90	CDD:312050	8/53 (15%)
		Ion_trans	92..357	CDD:306908	63/270 (23%)
		Interaction with KCTD3. /evidence=ECO:0000269\|PubMed:23382386	353..779		104/413 (25%)
		CAP_ED	427..535	CDD:237999	44/113 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..569		3/46 (7%)
		Atrophin-1	<585..773	CDD:331285	33/144 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	687..779		11/38 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3583
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960