DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and AgaP_AGAP009050

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_319802.4	Gene:	AgaP_AGAP009050 / 1280008	VectorBaseID:	AGAP009050	Length:	611	Species:	Anopheles gambiae

Alignment Length:	522	Identity:	231/522 - (44%)
Similarity:	322/522 - (61%)	Gaps:	41/522 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   562 AATAARKLH------------------FVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEIN 608
            :||:..:||                  ...||:....|.|..|||:|.|||...:|.|..|.|:|
Mosquito    66 SATSDTRLHQAGCVAPQAVPSDGVCSRLSVDPSLPSHYRWLSVVSLAVLYNIIFVIGRAVFWELN 130

  Fly   609 RRTIAIWFCLDYLSDFLYLIDILFHFRTGYLEDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDF 673
            ::...:|:.||||.||:||.|.|.|...||||.|:|..||.|||.||.:...:::|.:.:||.|.
Mosquito   131 KQASVLWWILDYLCDFIYLTDTLVHCHEGYLEQGLLVRDAPKLRKHYFSKQRWWLDVVSMLPTDL 195

  Fly   674 LYLSIGFNS----------ILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIFHWN 728
            .|:....:|          |:|..||:::.|.|.:.||||..|.|||.||...::..:||:.|||
Mosquito   196 AYIWWAPSSCAATRLPCPIIVRINRLLRLPRMWEWFDRTETATGYPNAFRICKVVLAILVLIHWN 260

  Fly   729 GCLYHIIHKNNGFGSRNWVY--HDSESADVVKQYLQSYYWCTLALTTIGDLPKPRSKGEYVFVIL 791
            .|||..|....||.:.||||  :..::..:.:||:.|:||.||.|||||:.|.|.:..||:||:.
Mosquito   261 ACLYFAISYALGFSTDNWVYNINGPKNLTLSRQYIYSFYWSTLTLTTIGETPTPENDAEYLFVVA 325

  Fly   792 QLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQ 856
            ..|.|:::|||::|::.:::::::..|.|||.::||||.||..|:|...|:.:||:||.|.|...
Mosquito   326 DFLAGVLIFATIVGNIGSMISNMNVTRVEFQNRMDGVKQYMAFRKVGGELEARVIRWFAYTWAQS 390

  Fly   857 KCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKG 921
            ...||||.::.|||||||||||.||:|||::|.|||:.|.|.|..|||:|:..:|||||||||||
Mosquito   391 GALDEERVLAALPDKLKAEIAIRVHMDTLRQVRIFQDCEPGLLEALVLKLKLQVFSPGDYICRKG 455

  Fly   922 EVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNM--GTAGNRRTASVRSVGYSDLFV 984
            :||||||||.||.|.||||:|.||:|:|.|||.|||:|:|.:  ...||||||:|||:||||||.
Mosquito   456 DVGKEMYIVKRGSLSVVADDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSIGYSDLFC 520

  Fly   985 LSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAPLEKVKYFNVVAMGRCQSTPGLVESCGRTSL 1049
            |:|:|:|:.|.:||.||..|.....:.|.  |...|::..:.|      .|.|...:|| |...|
Mosquito   521 LAKRDLWETLADYPEARASLTERGCQLLR--KDGLLDEAVFAN------AQQTQDSLES-GVARL 576

  Fly  1050 EE 1051
            |:
Mosquito   577 EQ 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	100/249 (40%)
		CAP_ED	890..1004	CDD:237999	73/115 (63%)
		DUF4655	1084..>1154	CDD:317882
AgaP_AGAP009050	XP_319802.4	Ion_trans	129..352	CDD:278921	87/222 (39%)
		Ion_trans_2	<297..347	CDD:285168	22/49 (45%)
		Crp	418..>542	CDD:223736	77/123 (63%)
		CAP_ED	424..540	CDD:237999	73/115 (63%)
		CLZ	540..611	CDD:293134	12/48 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820