DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42260 and Cnga1

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_006503772.1	Gene:	Cnga1 / 12788	MGIID:	88436	Length:	699	Species:	Mus musculus

Alignment Length:	524	Identity:	231/524 - (44%)
Similarity:	326/524 - (62%)	Gaps:	25/524 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   572 VFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFRT 636
            |.||:|...|.|...:::..:||:.:||.|..|.|:....:..|...||:||.:||.|:....||
Mouse   164 VIDPSGNTYYNWLFCITLPVMYNWTMIIARACFDELQSDYLEYWLIFDYVSDVVYLADMFVRTRT 228

  Fly   637 GYLEDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFN-SILRSFRLVKIYRFWAFMD 700
            ||||.|:|..|.:||...|..:..|.:|.|.::|.|.||:..|:| ..:|..||::|.|.:.|..
Mouse   229 GYLEQGLLVKDRMKLIEKYKANLQFKLDVLSVIPTDLLYIKFGWNYPEIRLNRLLRISRMFEFFQ 293

  Fly   701 RTERHTNYPNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWVY---HDSESADVVKQYLQ 762
            |||..|||||:||.:.|:.|:::|.|||.|:|:.|.|..|||:..|||   :|.|...:.::|:.
Mouse   294 RTETRTNYPNIFRISNLVMYIVIIIHWNACVYYSISKAIGFGNDTWVYPDVNDPEFGRLARKYVY 358

  Fly   763 SYYWCTLALTTIGDLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDG 827
            |.||.||.|||||:.|.|....||:||::..|.|:::|||::|::.:::::::|||.|||:::|.
Mouse   359 SLYWSTLTLTTIGETPPPVLDSEYIFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQSRVDA 423

  Fly   828 VKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQ 892
            :|.||..|.|...::.:|||||||||..:|..||...:..|||||:|||||||||||||:|.||.
Mouse   424 IKQYMNFRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLRYLPDKLRAEIAINVHLDTLKKVRIFA 488

  Fly   893 NTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGE 957
            :.|||.|.||||:|:|.::|||||||:||::|:||||:..|:|.||||:|.|....|..||||||
Mouse   489 DCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGSYFGE 553

  Fly   958 ISILNM--GTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAPL 1020
            |||||:  ..|||||||:::|:||||||.|||.|:.:.|.|||.|:..||....:.|.|
Mouse   554 ISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGRQILMK------ 612

  Fly  1021 EKVKYFNVVAMGRCQSTPGLVESCGRTSLEEMWLPPATAGASSLMHHHQALQQQHQASQQQPHRQ 1085
            :.:...|:..||   |.|        ..|||.  .....|:..|:....|.......|.||..:|
Mouse   613 DGLLDINIANMG---SDP--------KDLEEK--VTRMEGSVDLLQTRFARILAEYESMQQKLKQ 664

  Fly  1086 ESTQ 1089
            ..|:
Mouse   665 RLTK 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	97/241 (40%)
		CAP_ED	890..1004	CDD:237999	69/115 (60%)
		DUF4655	1084..>1154	CDD:317882	2/6 (33%)
Cnga1	XP_006503772.1	Ion_trans	172..414	CDD:366146	96/241 (40%)
		CAP_ED	486..602	CDD:237999	69/115 (60%)
		CLZ	602..671	CDD:374604	20/86 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5442
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	O	PTHR45638
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.820