DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and AgaP_AGAP002719

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_312206.5	Gene:	AgaP_AGAP002719 / 1273247	VectorBaseID:	AGAP002719	Length:	1017	Species:	Anopheles gambiae

Alignment Length:	711	Identity:	149/711 - (20%)
Similarity:	267/711 - (37%)	Gaps:	156/711 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   569 LHFVFDPAGRLCYY---WSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDI 630
            ||:        |.:   |..|:.....|...::.|..||:......::: ..:|.:.|.::.|||
Mosquito   263 LHY--------CAFKAIWDWVILCLTFYTAIMVPYNVAFKNKTSEDVSL-LVVDSIVDVIFFIDI 318

  Fly   631 LFHFRTGYL-EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLD----FLYLSIGFNSILRSFRLV 690
            :.:|.|.:: ..|.:.:|...:|.:|:.|. |.||.|..||.|    |.:...|..|:..:.::|
Mosquito   319 VLNFHTTFVGPGGEVVSDPKVIRMNYLKSW-FIIDLLSCLPYDVFNAFDHDEDGIGSLFSALKVV 382

  Fly   691 KIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIFHWNGCLYHIIHK---NNGFGSRNWVY---H 749
            ::.|....:.:.:|:..|........|..|:||. ||..|:::.|.:   :||.....:.|   :
Mosquito   383 RLLRLGRVVRKLDRYLEYGAAMLILLLCFYMLVA-HWLACIWYSIGRSDADNGVRRTPYSYIWSN 446

  Fly   750 DSESADVVK------QYLQSYYWCTLALTTIG-DLPKPRSKGEYVFVILQLLFGLMLFATVLGHV 807
            :|.:.::|.      .|:.:.|:....:|::| ......:..|.||.|..::...:|:||:.|||
Mosquito   447 ESNAPELVNGPSRKTMYVTALYFTMTCMTSVGFGNVAAETDNEKVFTICMMIIAALLYATIFGHV 511

  Fly   808 ANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKL 872
            ..|:..:::|..::...|:.|:.:|::..||..|..:|:.:....|...|..|.::.::..|..:
Mosquito   512 TTIIQQMTSATAKYHDMLNNVREFMKLHEVPKALSERVMDYVVSTWAMTKGLDTDKVLNYCPKDM 576

  Fly   873 KAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQV 937
            ||:|.::::.........|:....|.|..|.:.......:|||.:...||....:..:..|.|:|
Mosquito   577 KADICVHLNRKVFNEHPAFRLASDGCLRALAMHFCMSHSAPGDLLYHTGESIDSLCFIVTGSLEV 641

  Fly   938 VADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARV 1002
            :.|:  .|:|.|..|..||:                               ..|
Mosquito   642 IQDD--EVVAILGKGDVFGD-------------------------------SFW----------- 662

  Fly  1003 RLESIAVKRLEKYKKAPLEKVKYFNVVAMGRCQSTPGLVESCGRTSLEEMWLPPATAGASS---- 1063
              :..||.:......|.|...:....:.......:|....|.|         ||:..|..:
Mosquito   663 --KDSAVGQSAANLPAKLTLTEDTRALTTAVPSPSPSPSPSSG---------PPSAKGPRASKWG 716

  Fly  1064 -LMHHHQALQQQHQASQQQPHRQESTQTSSQTHGYSP--------RSYADRLARATDSPRSVSPS 1119
             |:          .:|........||:...:|...||        :...|....|..:|
Mosquito   717 RLL----------GSSSVDSASDTSTKIFPKTPKLSPGPGATLARQDTIDEGGEADHTP------ 765

  Fly  1120 AHGSEERPRSRTTSH---HSIRPQS---QPSHTGHICDSSSQLECYGAGVGGAGGGTTPLLGSHE 1178
            |.||..||..|...|   ..::|.|   ||:....:.|:::                     :..
Mosquito   766 ATGSTVRPPERPVVHMERELVKPPSLERQPTERDRLLDTAA---------------------TER 809

  Fly  1179 VLEDEIKRLRERLHTVESENQALNTKLSQQQWDLENRLA-EIEMQICGVSSTSSVDPENET 1238
            |.|.|.:|.|||....|.|.|            :|..|: |.|.||....|.|:.....:|
Mosquito   810 VRERERERERERERERERERQ------------MERNLSLERERQIEMAQSRSTTSDTYDT 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	61/258 (24%)
		CAP_ED	890..1004	CDD:237999	20/113 (18%)
		DUF4655	1084..>1154	CDD:317882	20/83 (24%)
AgaP_AGAP002719	XP_312206.5	PAS_9	28..135	CDD:290162
		PAS	39..133	CDD:238075
		Ion_trans	287..522	CDD:278921	57/237 (24%)
		Ion_trans_2	<463..517	CDD:285168	15/53 (28%)
		Crp	588..>665	CDD:223736	20/122 (16%)
		CAP_ED	594..>659	CDD:237999	18/66 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910