DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42260 and Hcn3

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_446137.1	Gene:	Hcn3 / 114245	RGDID:	620691	Length:	780	Species:	Rattus norvegicus

Alignment Length:	760	Identity:	183/760 - (24%)
Similarity:	309/760 - (40%)	Gaps:	158/760 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   508 PSQGGPGGPGPPHGGHPHHPHHGGAGSGG--GSGP-----------------------GSHGGQP 547
            |:.|......|.....|..|....|.|||  .|.|                       |||
  Rat     7 PAVGDGEAATPARETPPAAPAQARAASGGVPESAPEPKRRQLGTLLQPTVNKFSLRVFGSH---- 67

  Fly   548 HHQKPRRTASQRIRAATAARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFA-FQEINRRT 611
               |......:|:::|.|     ::..|.....:||.:::.:..:.|..|:..... |:|.|...
  Rat    68 ---KAVEIEQERVKSAGA-----WIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPP 124

  Fly   612 IAIWFCLDYLSDFLYLIDILFHFRTG-YLEDG---VLQTDALKLRTHYMNSTIFYIDCLCLLPLD 672
               |...:.|||..:|:|::.:|||| .:|:|   :|...|  :||.|:. |.|.:|.:..:|:|
  Rat   125 ---WIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRA--IRTRYLR-TWFLVDLISSIPVD 183

  Fly   673 FLYL--------------------SIGFNSILRSFRLVKIYRFWAFMDRTER--HTNY---PNLF 712
            :::|                    .:.|..||...||:::.|...:|.:.|.  |..|   ..:.
  Rat   184 YIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYMHQWEEIFHMTYDLASAVV 248

  Fly   713 RSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWV-YHDSESADVVKQYLQSYYWCTLALTTIG- 775
            |...||..:|::.||:|||..::.....|.|..|| .:...:....:||..:.:.....:..||
  Rat   249 RIFNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVSMNRMVNHSWGRQYSHALFKAMSHMLCIGY 313

  Fly   776 DLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNH 840
            ....|....:....:|.::.|...:|..:||...::.|:.::|:::|.|...|:.||...::|..
  Rat   314 GQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPAD 378

  Fly   841 LQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLR 905
            .:.::.:::::.: ..|..|||..:..|.:.|:.||........:..:.:|.:.:..|:..::.:
  Rat   379 TRQRIHEYYEHRY-QGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTK 442

  Fly   906 LRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGNRR 970
            ||..:|.|||.:.|:|.||::||.:..|.|.|:|...:.  ..|..|||||||.:|..|    ||
  Rat   443 LRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARD--TRLTDGSYFGEICLLTRG----RR 501

  Fly   971 TASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAPLEKVKYFNVVAMGRCQ 1035
            |||||:..|..|:.||......||:|:|..|...|::|:.||.:..|..       :::...|.:
  Rat   502 TASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLRRIGKKN-------SILQRKRSE 559

  Fly  1036 STPGLVESCGRTSLEEMWLPPATAGASSLMHHHQALQQQHQASQQQPHRQESTQTSSQTHG---- 1096
            .:||                   :.:..:|..|..   ||.....:..|..:..|.::..|
  Rat   560 PSPG-------------------SSSGGVMEQHLV---QHDRDMARGIRGLAPGTGARLSGKPVL 602

  Fly  1097 YSPRSYADRLARATDS-----------PRSVSP---------SAHGSEERPRS------------ 1129
            :.|..:|...|.|..|           |..:||         ||..|...|.|
  Rat   603 WEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSARRSAGSPASPLVPVRAGPLLA 667

  Fly  1130 ----RTTSHHSIRPQSQPSHTGHICDS---SSQLECYGAGVGGAG 1167
                .:||    |..:.|:.|.|...|   .||:...|...||.|
  Rat   668 RGPWASTS----RLPAPPARTLHASLSRTGRSQVSLLGPPPGGGG 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	64/269 (24%)
		CAP_ED	890..1004	CDD:237999	44/113 (39%)
		DUF4655	1084..>1154	CDD:317882	23/112 (21%)
Hcn3	NP_446137.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		11/39 (28%)
		Involved in subunit assembly. /evidence=ECO:0000250	45..90		8/56 (14%)
		Ion_trans_N	48..90	CDD:285597	8/53 (15%)
		Ion_trans	110..357	CDD:278921	60/252 (24%)
		Interaction with KCTD3. /evidence=ECO:0000250\|UniProtKB:O88705	353..780		100/396 (25%)
		Crp	421..>557	CDD:223736	49/148 (33%)
		CAP_ED	427..535	CDD:237999	44/113 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..569		3/45 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	687..780		7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3503
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.960