DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42260 and Kcnh4

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_446082.2	Gene:	Kcnh4 / 114032	RGDID:	621415	Length:	1016	Species:	Rattus norvegicus

Alignment Length:	814	Identity:	190/814 - (23%)
Similarity:	337/814 - (41%)	Gaps:	159/814 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   530 GGAGSGGGSGPGSHGGQPHHQK-PRRTASQRIRAA-----TAARKL--HF-------------VF 573
            ||.|.|   .||.||...|... .||.||.|:|:.     |...:|  ||             ||
  Rat   137 GGPGLG---SPGIHGDNNHENSLGRRGASSRLRSTRRQNRTVLHRLTGHFGRRDQGSVKANSNVF 198

  Fly   574 DP------------AGRLC---YY------WSMVVSMAFLYNFWVIIYRFAFQE------INRRT 611
            :|            .|..|   :|      |..::.:|..|....:.|...|..      .:|.|
  Rat   199 EPKPSVPEYKVASVGGSRCLLLHYSIPKAVWDGLILLATFYVAVTVPYNVCFAGDDDTPITSRHT 263

  Fly   612 IAIWFCLDYLSDFLYLIDILFHFRTGYL-EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLY 675
            :.    .|...:.|:::||:.:|||.|: :.|.:.:....:..||: :|.|::|.:..||.|.||
  Rat   264 LV----SDIAVEMLFILDIILNFRTTYVSQSGQVVSAPRSIGLHYL-ATWFFVDLIAALPFDLLY 323

  Fly   676 L-SIGFNSILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCLYHII 735
            : :|...|::...:.|::.|....:.:.||::..     |..::..|:.:|    ||..|::::|
  Rat   324 VFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQC-----SAVVLTLLMSVFALLAHWMACVWYVI 383

  Fly   736 HKNNGFGSRNWVYHDSESADV------------------------VKQYLQSYYWCTLALTTIG- 775
                  |.|....:|....|:                        ...|:.:.|:...:||::|
  Rat   384 ------GRREMEANDPLLWDIGWLHELGKRLEEPYVNGSAGGPSRRSAYIAALYFTLSSLTSVGF 442

  Fly   776 DLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNH 840
            ......:..|.:|.|..:|.|.::.|.|.|:|..|:..:.:.|..:.:::..:|.::|:.|:|..
  Rat   443 GNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRP 507

  Fly   841 LQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLR 905
            |:.:::::|...|......|....:...||:|:|:||::::.:.| ::.:|.....|.|..|.|.
  Rat   508 LKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLH 571

  Fly   906 LRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGT---AG 967
            ::....:||:::.|:|:..:..|.|..|.|:|:.||  ||:|.|..|...| ..|..:|.   ||
  Rat   572 IKTSFCAPGEFLLRRGDALQAHYYVCSGSLEVLRDN--TVLAILGKGDLIG-ADIPELGQEPGAG 633

  Fly   968 N----RRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAPLEKVKYFNV 1028
            .    :.:|.|:::.|..|..||.:.:.:||:.||      |.:|..|      |.|.:...||:
  Rat   634 AGCVLKTSADVKALTYCGLQQLSSRGLAEVLRLYP------EYVAAFR------AGLPRDLTFNL 686

  Fly  1029 ------VAMGRCQSTPGLVESCGRT--SLEEMWLPPAT-------AGASSLMHHHQALQQQHQAS 1078
                  ..:||...:|.|.::...|  |..:..||..|       .||.|.......|.   ..|
  Rat   687 RQGSENNGLGRFSRSPRLSQARSDTLGSSSDKTLPSITETEGGMEPGAGSKPRRPLLLP---NLS 748

  Fly  1079 QQQPHRQESTQTSSQTHGYSPRSYADRLARATDSP----RSVSPSAHG------SEERPRSRTTS 1133
            ..:|.....:....:...:|....:..|: .|.||    |..|||.||      :.:.|:..|..
  Rat   749 PARPRGSLVSLLGEELPPFSALVSSPSLS-PTPSPALAGRGSSPSLHGPPRGSAAWKPPQLLTPP 812

  Fly  1134 HHSIRPQS-QPSHTGHICDSSSQLECYGAGVGGAGGGT-----TPLLG---SHEVLEDEIKRLRE 1189
            ..:..|.. .|.....|.|||:..|............|     .||.|   |.|:..:..:.::|
  Rat   813 LGTFGPPDLSPRIVDGIEDSSNTAEAPTFRFSKRPEPTRTRSQAPLSGPRLSRELATEAAEEVKE 877

  Fly  1190 RLHTVESENQALNTKLSQQQWDLENRLAEIEMQI 1223
            ::..:..|...||.::||...:|...:..::.::
  Rat   878 KVCRLNQEISRLNQEVSQLSRELRQVMGLLQARL 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	59/280 (21%)
		CAP_ED	890..1004	CDD:237999	36/120 (30%)
		DUF4655	1084..>1154	CDD:317882	18/80 (23%)
Kcnh4	NP_446082.2	PRK13559	41..>134	CDD:237427
		PLN03192	177..>620	CDD:215625	104/461 (23%)
		Selectivity filter. /evidence=ECO:0000250	439..444		1/4 (25%)
		CAP_ED	578..667	CDD:412130	29/91 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	689..748		13/61 (21%)
		PHA03247	<732..1007	CDD:223021	39/184 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	770..869		25/99 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	971..1016
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910