DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and cnga2b

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_009299687.1	Gene:	cnga2b / 103911065	ZFINID:	ZDB-GENE-050307-2	Length:	682	Species:	Danio rerio

Alignment Length:	667	Identity:	251/667 - (37%)
Similarity:	355/667 - (53%)	Gaps:	99/667 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 GQSVSQQGFFTSHDSLATPCASRASNSHMATVSTASEMDLLHNKQRNKSRGRLKTAASGDQPLLG 426
            |||..:          .:||      ||..:|.|..:       :::::...|..:.|.......
Zfish    12 GQSAPE----------GSPC------SHRLSVQTQED-------EQDRAESVLSRSQSACDDTSS 53

  Fly   427 TWNRSTGRGSQD----NTLAGGGATS----LAMGGHNQYGGNYCNGTDRYPRSRSQQQGHHNAAQ 483
            ...|......||    |:..|.||.|    |.:                    ..::..|.:..:
Zfish    54 ELQRVAALEPQDAPSRNSFRGRGALSRLVTLVV--------------------TLREWAHRSLVE 98

  Fly   484 QAHHPYQLQHSASTVSHHPHAHGPPSQGGPGGPGPPHGGHPHHPHHGGAGSGGGSGPGSHGGQPH 548
            :...|    .|.......|....|||:.....|
Zfish    99 EEERP----DSFLERFRGPEVRAPPSRRSNNQP-------------------------------- 127

  Fly   549 HQKPRRTASQRIRAATAARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIA 613
                  .|:...:..|..:...|:...:....|||...::.|.|||:.:::.|..|.::...|..
Zfish   128 ------DANGNTKGITKKQWETFIVASSDDTYYYWLFFIAAAVLYNWVLLVARACFDQLQSETPI 186

  Fly   614 IWFCLDYLSDFLYLIDILFHFRTGYLEDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSI 678
            :|..|||:.||:|::|.....||||||.|:|..|..|||..|:::..|.:|.|.:||.|..|:..
Zfish   187 VWLVLDYICDFVYILDSCIRLRTGYLEQGLLVKDLAKLRDSYIHTFQFKLDVLSILPTDLAYIIT 251

  Fly   679 GFNS-ILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFG 742
            |.|: .||..||::..|.:.|.:|||..|||||:||...|:.|:|||.|||.|:::.|.|:.|||
Zfish   252 GINTPQLRFNRLLRFSRMFEFFNRTETRTNYPNIFRIWNLVLYILVIIHWNACIFYAISKSLGFG 316

  Fly   743 SRNWVY---HDSESADVVKQYLQSYYWCTLALTTIGDLPKPRSKGEYVFVILQLLFGLMLFATVL 804
            |..|||   ..:|...:.:.|:..:||.||.|||||::|.|....|||||:...|.|:::|||::
Zfish   317 SDEWVYPNISSTEEGALRRSYIYCFYWSTLTLTTIGEMPPPVRDEEYVFVVFDFLVGVLIFATIV 381

  Fly   805 GHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLP 869
            |:|.:::::::|.|.||||::|.:|.||..|:|..||:.:|||||||||..||..||:..:..||
Zfish   382 GNVGSMISNMNATRAEFQARIDAIKHYMHFRKVSRHLETRVIKWFDYLWTNQKAVDEQEVLKNLP 446

  Fly   870 DKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGR 934
            |||:|||||||||.|||:|.|||:.|||.|.||||:|||.::||||||||||::||||||:..|:
Zfish   447 DKLRAEIAINVHLTTLKKVRIFQDCEAGLLVELVLKLRPQVYSPGDYICRKGDIGKEMYIIKEGK 511

  Fly   935 LQVVADNGKTVMASLKAGSYFGEISILNM--GTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEY 997
            |.||||:|.|..|.|.||..||||||||:  ...||||||::||:||||||.|||.|:.:.:.||
Zfish   512 LAVVADDGVTQFALLTAGGCFGEISILNIQGSKMGNRRTANIRSIGYSDLFCLSKDDLMEAVIEY 576

  Fly   998 PAARVRLESIAVKRLEK 1014
            |.|:..||....:.|.|
Zfish   577 PDAQRVLEERGREILRK 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	100/241 (41%)
		CAP_ED	890..1004	CDD:237999	72/115 (63%)
		DUF4655	1084..>1154	CDD:317882
cnga2b	XP_009299687.1	Ion_trans	153..395	CDD:306908	100/241 (41%)
		CAP_ED	467..583	CDD:237999	72/115 (63%)
		CLZ	583..653	CDD:318679	4/11 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5401
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	O	PTHR45638
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.010