DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and kcnh1b

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_009294796.1	Gene:	kcnh1b / 101154640	ZFINID:	ZDB-GENE-121128-4	Length:	965	Species:	Danio rerio

Alignment Length:	788	Identity:	175/788 - (22%)
Similarity:	316/788 - (40%)	Gaps:	164/788 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   569 LHFVFDPAGRLCYY---WSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDI 630
            ||:        |.:   |..|:.:...|...::.|..:|:  .::....|..:|.:.|.::|:||
Zfish   218 LHY--------CTFKTTWDWVILILTFYTAIMVPYNVSFK--TKQNNVTWLVVDSIVDVIFLVDI 272

  Fly   631 LFHFRTGYL-EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLD----FLYLSIGFNSILRSFRLV 690
            :.:|.|.:: ..|.:.:|...:|.:|: .|.|.||.|..||.|    |..:..|.:|:..|.::|
Zfish   273 VLNFHTTFVGPAGEVISDPKLIRMNYV-KTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVV 336

  Fly   691 KIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCL------YHIIHKN------- 738
            ::.|......:.:.:..|     ..|::..|:.:|    ||..|:      |.:|.::
Zfish   337 RLLRLGRVARKLDHYIEY-----GAAVLVLLVCVFGLAAHWLACIWYSIGDYEVIDQDANMVRTD 396

  Fly   739 ----------------NGFGSRNWVYHDSESADVVKQYLQSYYWCTLALTTIG-DLPKPRSKGEY 786
                            |..||..|  ....|.|.|  |:.|.|:...:||:|| ....|.:.||.
Zfish   397 SWLYLLGEAVGQPYHFNASGSGKW--EGGPSKDSV--YITSLYFTMTSLTSIGFGNIAPTTDGEK 457

  Fly   787 VFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDY 851
            :|.:..::.|.:|:||:.|:|.||...:.|....:...|:.|:.::::.:||..|..:|:.:...
Zfish   458 IFAVAMMMIGSLLYATIFGNVTNIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVS 522

  Fly   852 LWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDY 916
            .|...:..|.::.:...|..::|:|.::::....|....|:....|.|..|.:..:.:..:|||.
Zfish   523 TWSMSRGIDTDKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTIHSAPGDL 587

  Fly   917 ICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSD 981
            |...||....:..|..|.|:|:.|:  .|:|.|..|..||::....:..|  :..|:||::.|.|
Zfish   588 IYHAGESVDSLCFVVSGSLEVIQDD--EVVAILGKGDVFGDVFWKEVNLA--QSCANVRALTYCD 648

  Fly   982 LFVLSKKDMWDVLKEYPA----------------ARVRLESIA-VKR-----LEKYKKAPL---- 1020
            |.::.:..:..||:.|.|                .|:....|: |||     |.:..:|||
Zfish   649 LHIIKRDALQKVLEFYTAFAGHFSRNLVLTYNLRKRIVFRKISDVKREEEEMLRRKNEAPLNLPP 713

  Fly  1021 ---------------------EKVKYFNV-VAMGRCQSTPGLVESCGRTSLEEMWLPPATAGASS 1063
                                 |:...... |..|:.:.|. :.|....||:..:...|||  .::
Zfish   714 DHPVRRLFQRFRQQREARLAAERANQVEQDVEKGKSEQTV-VKEITSPTSIITVTESPAT--LNT 775

  Fly  1064 LMHHHQALQQQHQASQQQPHRQESTQTSSQTHGYSPRS-----YADRLARATDSPRSVSPSAHGS 1123
            |.....:.:...:|....|....:.|.|::    :|:|     :.:..|::..|..||| .|...
Zfish   776 LSPTTPSTKTLCRAKLNTPLAPNTAQKSAE----APKSKGWSRFKEATAKSDLSLSSVS-KAESM 835

  Fly  1124 EERPRSRTTSHHSIRPQSQPSHTGHICDSSSQLECYGAGVGGAGGGTTPLLGSHEVLEDEIKRL- 1187
            |..| .||.|...:....:...    |||.  :......:...|...||  .....::.|.|||
Zfish   836 EMLP-DRTKSQDELLSLKKTDS----CDSG--ITKSDPRLDNMGSAETP--QDRSPVQPEEKRLF 891

  Fly  1188 ------------RERLHTVESENQALNTKLSQQQWDLENRLAEI-----EMQICG------VSST 1229
                        .|....::.:..:|..::|.    ||.:|||:     |....|      :|..
Zfish   892 YPIPEHSLQACFSELRQDLQGDIHSLGCRMSA----LEGQLAEMLRLLAERNSSGPAELHHISRP 952

  Fly  1230 SSVDPENE 1237
            :|.|.|.:
Zfish   953 NSPDSEKD 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	67/279 (24%)
		CAP_ED	890..1004	CDD:237999	33/129 (26%)
		DUF4655	1084..>1154	CDD:317882	18/74 (24%)
kcnh1b	XP_009294796.1	PAS_9	46..142	CDD:290162
		PAS	46..140	CDD:238075
		Ion_trans	242..490	CDD:278921	64/259 (25%)
		Ion_trans_2	<430..484	CDD:285168	19/53 (36%)
		Crp	555..>692	CDD:223736	35/140 (25%)
		CAP_ED	561..668	CDD:237999	32/110 (29%)
		Mucin	733..828	CDD:250634	19/101 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910