DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42260 and hcn4

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_002944030.2	Gene:	hcn4 / 100498501	XenbaseID:	XB-GENE-940130	Length:	2061	Species:	Xenopus tropicalis

Alignment Length:	1350	Identity:	285/1350 - (21%)
Similarity:	483/1350 - (35%)	Gaps:	353/1350 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PGHELDEIAVVSGTGSSSHHFSYGGCLATGDAPLPRYSTAATPSLRRATAIDGDADADADADAGA 99
            |.|...::|..|.:...||          ..|.:|.:|.|..||         .:.|...:....
Frog   802 PSHSPAQVASHSPSQVPSH----------SPAQVPSHSPAQVPS---------HSPAQVPSHCAL 847

  Fly   100 DGNDNENHVDGYSDDDDDDERWLRAARAQKVQKAQTQAYAAHNDRPQTKTTVAIRQNNGSNKS-- 162
            :| ...:.|.|.:.           .....|.|:.||   |.|.:|.|         :|:::|
Frog   848 EG-PKPSPVPGANQ-----------PIYPSVIKSPTQ---APNHQPNT---------HGNSQSPA 888

  Fly   163 --NSNSNSKCNSSSSNNNNNYKSATTSQSNINHRLAPRASFPEIMQPRLSLNGLLNPSLMPSPRP 225
              :..|.:...|.||       :..:||||   .|.|..|...:.....:|....:|:|:||..|
Frog   889 LESIQSPALVPSKSS-------ALASSQSN---ALVPSQSSALVPSQSSALASRKSPALVPSQSP 943

  Fly   226 LYRDHSSRSINPLTAYEQQMAELDGSFYASNAGYLGAGMGGSAGDGTTCTNLTVGGGSTGGGAMA 290
            ....:.|..:.|     .|...|..:.|::.                         ||:...|:|
Frog   944 ALSSNQSLVLVP-----SQSPALVPTQYSAL-------------------------GSSQSPALA 978

  Fly   291 SGGGGTSAQVGGGGGGSGGGGAAIHTTELSITPTMAGDEQFIDLGSLRRFSIDRQSFLDLGPKFG 355
            .                            |.:||:|..:....:.|.....:..||
Frog   979 P----------------------------SQSPTVACSQSPALVPSQSPALVPSQS--------- 1006

  Fly   356 MTQPKFGQSVSQQGFFTSHDSLATPCASRASNSHMATVSTASEMDLLHNKQRNKSRGRLKTAASG 420
               |....|.|.....:...:|| ||.|.:.....::...:|:...|...|..........|...
Frog  1007 ---PALAPSQSPTVACSQSPALA-PCQSPSVVPSQSSALASSQSPALAPSQSPALAPSQSPALVP 1067

  Fly   421 DQPLLGTWNRSTGRGSQDNTLAGGGATSLAMGGHNQYGGNYCN----GTDRYPRSRSQQQGHHNA 481
            .||.....:.|..:|...:...|.                 |:    |:.:.|.....|......
Frog  1068 TQPAAVISSESPAQGPSQSPFQGS-----------------CHVPTQGSIQSPAQEPSQSPAKVP 1115

  Fly   482 AQQAHH-----PYQLQHSASTVSHHPHAHGPPSQGGPGGPGPPHGGHPHHPHHGGAGSGG----- 536
            :|...|     |.::...|:.....|.....|||.       |.....|.|....:.|..
Frog  1116 SQCPLHVPSQCPVRVPTQATAQDSCPLTAQAPSQS-------PAQISSHSPAQISSQSPAQELSS 1173

  Fly   537 ------GSGP---GSHGG----------QP----------HHQKPRRTASQRIRAATAARKLHFV 572
                  ||..   |..||          ||          ...|......||:::|.:     ::
Frog  1174 LIPKLEGSEQTEVGDPGGFIQRQFGALLQPAVNKFSLRMFGSHKAVEIEQQRVKSAGS-----WI 1233

  Fly   573 FDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFRTG 637
            ..|.....:||.:::.:..:.|..::.....|  ........|...:.|||..:|.|::.:||||
Frog  1234 IHPYSDFRFYWDLIMLLLMVANLIILPVGITF--FKDENTPPWIVFNVLSDTFFLADLVLNFRTG 1296

  Fly   638 -YLEDG---VLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIG------------------- 679
             .:||.   :|....:|::  |:.|. |.:|.:..:|:|:::|.:.
Frog  1297 IVVEDNTEIILDPHTIKMK--YLKSW-FLVDFVSSIPVDYIFLIVDLETNVDTEVYKTARALRIV 1358

  Fly   680 -FNSILRSFRLVKIYRFWAFMDRTER--HTNY---PNLFRSTALIHYLLVIFHWNGCLYHIIHKN 738
             |..||...||:::.|...::.:.|.  |..|   ..:.|...||..:|::.||:|||..::...
Frog  1359 RFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPML 1423

  Fly   739 NGFGSRNWV---YHDSESADVVKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFVILQLLFGLML 799
            ..|....||   :..:||..  |||..:.:.....:..|| ....|....:....:|.::.|...
Frog  1424 QDFPEDCWVSINHMANESWG--KQYSHAIFKAMSHMLCIGYGQQAPEGMTDVWLTMLSMIVGATC 1486

  Fly   800 FATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERA 864
            :|..:||...::.|:.::|:::|.|...|:.||...::|...:.::.:::::.: ..|..|||..
Frog  1487 YAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHEYYEHRY-QGKMFDEENI 1550

  Fly   865 VSCLPDKLKAEIAINVHLDTL-KRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMY 928
            :..|.:.||.|| :|.:...| ..:.:|.|.:..|:..::.:||..:|.|||||.|:|.|||:||
Frog  1551 LGELSEPLKEEI-VNFNCRNLVANMPLFANADPNFVTAMLTKLRFEVFQPGDYIIREGTVGKKMY 1614

  Fly   929 IVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFVLSKKDMWDV 993
            .:..|.:.::....|.  ..|..|||||||.:|..|    |||||||:..|..|:.||..:..:|
Frog  1615 FIQHGVVSILTRGSKE--TKLSDGSYFGEICLLTRG----RRTASVRADTYCRLYSLSVDNFNEV 1673

  Fly   994 LKEYPAARVRLESIAVKRLEKYKKAPLEKVKYFNVVAMGRCQSTPGLVES--------------- 1043
            |:|||..|...|::|:.||::..|..       :::...|.:::.|.|.:
Frog  1674 LEEYPMMRRAFETVAMDRLDRIGKKN-------SILLRKRAENSSGSVNNEIIQQIVKHDRDTAH 1731

  Fly  1044 ------CGRTSLEE----MWLP---------PATAGASSLMHHHQALQQ---------------Q 1074
                  |...:.:.    :|.|         .||...:..:.|.|.||.               .
Frog  1732 NIQDIQCLAATRDPNKPFIWEPLVHAPLQTAAATTNVAIALTHQQNLQANVFLPPLSLPETAYVS 1796

  Fly  1075 HQASQQQPHRQESTQTS------SQTH-----GYSPRSYADRLARATDSPRSVSPSAHGSEERPR 1128
            .||.:.||..:.|..:|      :|:|     |.||.|.:....::.:......|......:|..
Frog  1797 RQARRSQPSLRGSHPSSVSSPSGTQSHLQTPLGISPSSPSGVQKQSINGQCPQIPIRLSQSQRGE 1861

  Fly  1129 SRTTSHHSIRP-QSQPSHTGHICDSSSQLECYGAGVGGAGGGTTP--------------LLGSH- 1177
            .:|.:...|.| |.|.|.:.....|:|.|:   .|:|.||....|              ..|||
Frog  1862 PQTAAKPPILPSQVQLSRSRGTSASTSVLQ---QGMGPAGSPVVPGSLSGRTLHYSLSRASGSHI 1923

  Fly  1178 EVLEDE------------------IKRLRERLHTVESENQALNTKLSQQQ 1209
            .:|..:                  |.||.:.:..:.:...:|..|::.||
Frog  1924 SLLMQQAASSPQQLVKYRSIQGLPIGRLSQDVRLMSASQPSLPNKVTHQQ 1973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	60/270 (22%)
		CAP_ED	890..1004	CDD:237999	47/113 (42%)
		DUF4655	1084..>1154	CDD:317882	17/81 (21%)
hcn4	XP_002944030.2	Plasmodium_HRP	<67..248	CDD:253181
		Ion_trans_N	1197..1239	CDD:285597	7/46 (15%)
		Ion_trans	1259..1506	CDD:278921	57/253 (23%)
		Crp	1570..>1708	CDD:223736	54/150 (36%)
		CAP_ED	1576..1684	CDD:237999	47/113 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910