DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42260 and cngb3

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_017950391.2	Gene:	cngb3 / 100497119	XenbaseID:	XB-GENE-6035542	Length:	784	Species:	Xenopus tropicalis

Alignment Length:	820	Identity:	226/820 - (27%)
Similarity:	369/820 - (45%)	Gaps:	133/820 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   386 SNSHMATVSTASEMDLLHNKQRNKSRGRLKTAASGDQPLLGTWNRSTGRGSQDNTLAGGGATSLA 450
            |::....|||..:..|...|. ||...||...|....||:.:..:......:          .|.
Frog    23 SSNRKQEVSTEEDKKLSGEKV-NKVAPRLNAGAVFRVPLVISAMKGIVHAKR----------KLN 76

  Fly   451 MGGHNQYG--GNYCNGTDRYPRSRSQQQGHHNAAQQAHHPYQLQHSASTVSH-HPHAHGPPSQGG 512
            :..|.|..  |....|:.|...:.:|.|......::....|:.:.:...:|. .|.....|.:..
Frog    77 LKRHFQMSREGLQAQGSKRNEYAEAQLQDLFKRMRERTSHYKDKLADPDISSAEPSPTATPVKPK 141

  Fly   513 PGGPGPPHGGHPHHPHHGGAGSGGGSGPGSHGGQPHHQKPRRTASQRIRAATAARKLHFVFDPAG 577
            |..|.||                    |.....:|..:..::...|    |..|.|.|:    ..
Frog   142 PAPPPPP--------------------PPKKEEKPEAKDEKQAEKQ----AEEAEKEHY----CD 178

  Fly   578 RLC-----------------------------YYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIA 613
            .||                             ..|...|:::|.:|.|:|..|..|.......|.
Frog   179 MLCCKFKRPTLKKSLQKFKLPSSIDAYTDHSYLLWLFFVAVSFNWNCWLIPMRCVFPVQTPNNIL 243

  Fly   614 IWFCLDYLSDFLYLIDI-LFHFRTGYLEDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLS 677
            .|...||:.|.|||||| :|..|..:::.|.:.|:..:.:.:|..||.|.:|...::|.|.||:.
Frog   244 YWMISDYICDALYLIDIFIFQPRLQFVKGGDIITERKQTKANYWESTKFRLDVASVIPFDLLYMV 308

  Fly   678 IGFNSILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFG 742
            .||..:.|:.||:|...|:.|.||.|.......::|......|||.|.|.|.|:|:......|..
Frog   309 FGFQPVFRANRLLKYTSFFEFNDRLEAVMEKAYIYRVIRTTGYLLFILHINACIYYWASSYEGIA 373

  Fly   743 SRNWVYHDSESADVVKQYLQSYYWCTLALTTIGDLPKPRSKGEYVFVILQLLFGLMLFATVLGHV 807
            |..||| |.:.    ..||:.||:....|.|||.|.:|::..|.||.:|....|:.:|::::|.:
Frog   374 STKWVY-DGKG----NMYLRCYYFAVRTLITIGGLAEPQTVFEIVFQLLNYFTGVFVFSSLIGQM 433

  Fly   808 ANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKL 872
            .:::.:.:|.:..::|.:|...:||...::|..:|.:|..|::|.|.:|...||...:..:|.|:
Frog   434 RDVIGAATAGQSYYRASVDKTVSYMSSNKIPKVVQNRVRTWYEYTWDSQGMLDESELLEEMPTKM 498

  Fly   873 KAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQV 937
            :..|||:|:...:.||::|:..::..:.:|:|||:.:::.|||::|:|||:|:||||:.:|.:||
Frog   499 QLAIAIDVNFAIVDRVDLFKGCDSQMIQDLLLRLKSIVYLPGDFVCKKGEIGREMYIIKQGAVQV 563

  Fly   938 VA--DNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAA 1000
            :.  ||.| |:.:||||:.|||||:|:.| .||||||:|.:.|:::||:|.||.:.::|..||.:
Frog   564 LGGPDNQK-VLVTLKAGAVFGEISLLSAG-GGNRRTANVVAYGFANLFILDKKSLNEILVHYPDS 626

  Fly  1001 RVRLESIAVKRL-EKYKKA-PLEKVKYFNVVAMGRCQSTPGLVE-----SCGRTSLEEMWLPPAT 1058
            :..|...|.|.| ||.|.| |....|.|..:...: ..||.|.:     :.|||
Frog   627 KKLLTKKAKKLLKEKGKPAGPAVVNKGFGHLIPPK-PETPRLFKALMSATSGRT----------- 679

  Fly  1059 AGASSLMHHHQALQQQHQ---------ASQQQPHRQES---------TQTSSQ-------THGYS 1098
             |.|.|....||...:::         .|...|.:|:.         |:.|.:       |.|.:
Frog   680 -GLSLLTRLKQATSNENKEVNKTSDMAKSTDDPAKQKEKSNVQDAKLTEESKEQPAGARATPGAA 743

  Fly  1099 PRSYADRLARATDSPRSVSPSAHGS-------EERPRSRT 1131
            |:..|...:::.....|:||||...       |.|.|.:|
Frog   744 PKPDATAGSKSKSFIISMSPSAKAGEGELLTVEVRDRKKT 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	76/238 (32%)
		CAP_ED	890..1004	CDD:237999	51/115 (44%)
		DUF4655	1084..>1154	CDD:317882	16/71 (23%)
cngb3	XP_017950391.2	PLN03192	207..>589	CDD:215625	130/387 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920