Protein Alignment CG42260 and kcnh3

DIOPT Version :10

• Sequence 1: NP_001356969.1
• Gene: CG42260 / 37614
• FlyBaseID: FBgn0259145
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_031753016.1
• Gene: kcnh3 / 100494380
• XenbaseID: XB-GENE-952637
• Length: 950
• Species: Xenopus tropicalis
• Alignment Length: 789
• Identity: 171/789 - (21%)
• Similarity: 299/789 - (37%)
• Gaps: 219/789 - (27%)

  Fly   565 AARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQE------INRRTIAIWFCLDYLSD 623
            :.||...:|...|.....|..::.:|.||....:.|...|..      |.|....:  | |.:.:
 Frog   208 SVRKSPLIFLHYGTFKACWDCLILLATLYVAVTVPYSVCFSNKEEGTTIPRSPPNV--C-DLIVE 269

  Fly   624 FLYLIDILFHFRTGYLEDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLY---LSIGFNS-IL 684
            .|:::||..:|||.::..........:|..|:...|.|.:|.|..||:|.||   :::.|.: :|
 Frog   270 ILFILDIALNFRTTFVSQSGKVVFTPRLIVHHYLRTWFLLDLLAALPVDLLYSFNVNVYFGAHLL 334

  Fly   685 RSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCLYHIIHKNN------ 739
            ::.||:::.|   .:.|.:.::.|     |..::..|:|:|    ||..|:::.|.:..
 Frog   335 KTVRLLRLLR---LLPRLDHYSRY-----SAVVLSLLMVVFALLAHWVACIWYFIGQKEIESNQP 391

  Fly   740 -----GF--------------GSRNWVY------HDSESA----DVV--------KQYLQSYYWC 767
                 |:              |.||...      ::||.|    |:|        ..|:.|.|:.
 Frog   392 EVPEIGWLQELARRLETPYYVGKRNSSQCFTPQNNNSEEAANKTDMVLLGGPSLRSSYITSLYFA 456

  Fly   768 TLALTTIG-DLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTY 831
            ..:||::| ......:..|.:|.:..:|.|.::.|.|.|:|..|:..:.|.|..:.::...::.|
 Frog   457 LSSLTSVGFGNVSANTDTEKIFSLCIMLIGALMHALVFGNVTAIIQRLYARRFLYHSRTRDLRDY 521

  Fly   832 MRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEA 896
            :|:..:|..|:.:::::....|......|..:.:..|||:|:|:||::::.:.|:. .:|.....
 Frog   522 IRIHAIPKPLKQRMLEYVQTTWTMNNGIDTNQLLHSLPDELRADIAMHLNRELLQS-PLFALASR 585

  Fly   897 GFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFG----- 956
            |.|..|.|.:|....:||:|:.|:|:..:.:|.|..|.::|:.|.  .|:|.|..|...|
 Frog   586 GCLRSLSLNIRRSFCTPGEYLIRQGDALEALYCVCSGSMEVLKDG--VVLAILGKGDLIGCELCS 648

  Fly   957 -EISILNMGTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAPL 1020
             :|.|        :..|.|:::.|.||..:.::.:.|.|..||
 Frog   649 EDIVI--------KSNADVKALTYCDLQGIGQRGLRDTLSLYP---------------------- 683

  Fly  1021 EKVKYFNVVAMGRCQSTPGLVESCGRTSLEEMWLPPATAGASSLMHHHQALQQQHQASQQQPHRQ 1085
            |..:.|.      ||.|..|               ....|.|...|......||...:|
 Frog   684 EYAQKFT------CQITKQL---------------SYNLGGSKCAHESDVYAQQLFENQ------ 721

  Fly  1086 ESTQTSSQTHGYSPRSYADRLARATDSPR-SVSPSAHGSEERPRSRTTSHHSIRPQSQPSHTGHI 1149
                   .:||          .|..:||: ||                   |:.||..|    |:
 Frog   722 -------NSHG----------KRQEESPKFSV-------------------SLTPQKSP----HL 746

  Fly  1150 CDSSSQ--------------LECYGAGVGG------AGGGTTPLLGSHEVL----EDEIKRLRER 1190
            |.|.|:              |.....|||.      ......|...|..|:    |:....:.||
 Frog   747 CSSPSRFSLCSPRRTAKEMTLSHTPTGVGARELDIPCVSYARPTELSPRVVDGIEEENSTAVPER 811

  Fly  1191 LHTVESEN------QALNTKLSQQQWDLENRLAEIEMQICGVSSTSSVDPENETEELERNRESI- 1248
            .:..|..|      :.|......:..|...||::      .||..||     :.:||....:::
 Frog   812 FNFPECNNPPATSGEPLFLSTEPRATDNMERLSQ------AVSDLSS-----QVQELREGLQALR 865

  Fly  1249 -IXHGSVLP 1256
             ..|.||:|
 Frog   866 HAMHVSVMP 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..820	CDD:459842	68/296 (23%)
		CAP_ED	890..1004	CDD:237999	32/119 (27%)
kcnh3	XP_031753016.1	PAS_9	39..135	CDD:463873
		PLN03192	225..>643	CDD:215625	102/431 (24%)
		PRK11753	606..>697	CDD:236969	28/128 (22%)