DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and kcnh8

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_031760363.1	Gene:	kcnh8 / 100490406	XenbaseID:	XB-GENE-981673	Length:	1114	Species:	Xenopus tropicalis

Alignment Length:	826	Identity:	173/826 - (20%)
Similarity:	334/826 - (40%)	Gaps:	202/826 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   569 LHF-VFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQE----INRRTIAIWFCLDYLSDFLYLI 628
            ||| .|..|      |..::.:|..|....:.|..:|::    .:.|:..:   .|...:.|::.
Frog   215 LHFSTFKAA------WDWLILLATFYVAVTVPYNVSFEDNDDPSSTRSTTV---SDISVEILFIT 270

  Fly   629 DILFHFRTGYL-EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFN----------S 682
            ||:.:|||.|: |.|.:...:..:..||: :|.|.||.:..||.|.||   .||          .
Frog   271 DIILNFRTTYVSESGQVIFKSRSICIHYV-TTWFVIDLIAALPFDLLY---AFNVTVDNLVSLVH 331

  Fly   683 ILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCLYHIIHKNNGFGS 743
            :|::.||:::.|....:||..:|        ||.::..|:.:|    ||..|::::|.|   ...
Frog   332 LLKTIRLLRLLRLLQKLDRYSQH--------STIVLTLLMSMFALLAHWMACIWYVIGK---MEM 385

  Fly   744 RN--------WVY------------HDSESADVVKQ-YLQSYYWCTLALTTIG--------DLPK 779
            :|        |::            :||:....::. |:.|.|:...:||::|        |:.|
Frog   386 KNKPLSWDIGWLHELGKRLESPFHSNDSQGGPTIRSTYIASLYFTLSSLTSVGFGNVSANTDVEK 450

  Fly   780 PRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVK 844
                   :|.|..:|.|.::.|.|.|:|..|:..:.:....:..:...:|.::|:..:|..|:.:
Frog   451 -------IFSICIMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQR 508

  Fly   845 VIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPV 909
            ::::|...|......|....:...||:|:::|.:.::.:.| ::.:|::...|.|..|.|.::..
Frog   509 MLEYFQTNWSVNNGIDSHELLKDFPDELRSDITMYLNKEIL-QLSLFESASRGCLRSLSLHIKTS 572

  Fly   910 LFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFG-EISILNMGTAGNRRTAS 973
            ..:||:|:.|:|:..:.:|:|..|.::|:.|.  .|:|.|..|...| .:||.:.....|   |.
Frog   573 FCAPGEYLLRQGDALQAIYLVCSGSMEVLKDG--MVLAILGKGDLIGANLSIKDQVIKTN---AD 632

  Fly   974 VRSVGYSDLFVLSKKDMWDVLKEYPA-ARVRLESI----AVKRLEKYKKAPLEKVKYFNVVAMGR 1033
            |:::.|.||..:..|.:::||..||. |...:|.|    .....|.::...:.::.
Frog   633 VKALTYCDLQCIILKGLYEVLDFYPEYAHTFVEHIQQDLTYNLREGHESDRMSRLS--------- 688

  Fly  1034 CQSTPGLVESCGRTSLEEMWLPPATAGASSLMH-HHQALQQQHQASQQQPH------RQESTQTS 1091
            |:||....:..|..|:...        .||::. ..:..::...:|....|      :.:.:.||
Frog   689 CKSTLSQTDLRGNGSINNR--------LSSIVEDEDEDTEEDEPSSPSSIHTRNTASKYKKSATS 745

  Fly  1092 SQTHGYSPRSYADRLARATDSP-RSVSPSA----HGSEERPRSRTTSHHSI----------RPQS 1141
            :.:.|.:.:|:...:  ...|| |:.:||:    ..:|....||...::.:          .|..
Frog   746 NSSLGINLKSFPGTV--PFKSPLRTCNPSSTMARQENEPNLNSRKRENNLMLNLPTVTSLGPPDL 808

  Fly  1142 QPSHTGHICDSSS-------QLECY----GAGVGG---------------AGGGTTPLLG--SHE 1178
            .|.....|.|.:|       ..|.|    .|.:|.               ....|...:|  :||
Frog   809 SPRVVDGIEDHNSNDEGQAFDFEAYRLRQEARLGQPIREVSDFNPAILFITAEETKQQIGRLNHE 873

  Fly  1179 V--LEDEIKRLRERLHTVES--EN------------------QALNTKLSQQQWDLENRLAEIEM 1221
            |  |..::.:|.:.:.:|.:  ||                  .|:.|.:......::||:.....
Frog   874 VSSLTQKVSQLGKDMKSVMNILENLLAVQRPVGYYSTYGTVLDAIRTTIGSPMEQIQNRMTWTTN 938

  Fly  1222 QIC-------------------GVSSTSSVDPENETEELERNRESI 1248
            |.|                   .||...::||.:.....:||..:|
Frog   939 QSCMQRPAETLVGTPTQLCQGAVVSDLWNMDPASVGSSPQRNGSNI 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	66/285 (23%)
		CAP_ED	890..1004	CDD:237999	34/115 (30%)
		DUF4655	1084..>1154	CDD:317882	16/84 (19%)
kcnh8	XP_031760363.1	PAS_9	40..135	CDD:404329
		PLN03192	200..>617	CDD:215625	102/435 (23%)
		PRK11753	580..>658	CDD:236969	24/82 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910