Protein Alignment CG42260 and kcnh8

DIOPT Version :10

• Sequence 1: NP_001356969.1
• Gene: CG42260 / 37614
• FlyBaseID: FBgn0259145
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_031760363.1
• Gene: kcnh8 / 100490406
• XenbaseID: XB-GENE-981673
• Length: 1114
• Species: Xenopus tropicalis
• Alignment Length: 826
• Identity: 173/826 - (20%)
• Similarity: 334/826 - (40%)
• Gaps: 202/826 - (24%)

  Fly   569 LHF-VFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQE----INRRTIAIWFCLDYLSDFLYLI 628
            ||| .|..|      |..::.:|..|....:.|..:|::    .:.|:..:   .|...:.|::.
 Frog   215 LHFSTFKAA------WDWLILLATFYVAVTVPYNVSFEDNDDPSSTRSTTV---SDISVEILFIT 270

  Fly   629 DILFHFRTGYL-EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFN----------S 682
            ||:.:|||.|: |.|.:...:..:..||: :|.|.||.:..||.|.||   .||          .
 Frog   271 DIILNFRTTYVSESGQVIFKSRSICIHYV-TTWFVIDLIAALPFDLLY---AFNVTVDNLVSLVH 331

  Fly   683 ILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCLYHIIHKNNGFGS 743
            :|::.||:::.|....:||..:|        ||.::..|:.:|    ||..|::::|.|   ...
 Frog   332 LLKTIRLLRLLRLLQKLDRYSQH--------STIVLTLLMSMFALLAHWMACIWYVIGK---MEM 385

  Fly   744 RN--------WVY------------HDSESADVVKQ-YLQSYYWCTLALTTIG--------DLPK 779
            :|        |::            :||:....::. |:.|.|:...:||::|        |:.|
 Frog   386 KNKPLSWDIGWLHELGKRLESPFHSNDSQGGPTIRSTYIASLYFTLSSLTSVGFGNVSANTDVEK 450

  Fly   780 PRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVK 844
                   :|.|..:|.|.::.|.|.|:|..|:..:.:....:..:...:|.::|:..:|..|:.:
 Frog   451 -------IFSICIMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQR 508

  Fly   845 VIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPV 909
            ::::|...|......|....:...||:|:::|.:.::.:.| ::.:|::...|.|..|.|.::..
 Frog   509 MLEYFQTNWSVNNGIDSHELLKDFPDELRSDITMYLNKEIL-QLSLFESASRGCLRSLSLHIKTS 572

  Fly   910 LFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFG-EISILNMGTAGNRRTAS 973
            ..:||:|:.|:|:..:.:|:|..|.::|:.|.  .|:|.|..|...| .:||.:.....|   |.
 Frog   573 FCAPGEYLLRQGDALQAIYLVCSGSMEVLKDG--MVLAILGKGDLIGANLSIKDQVIKTN---AD 632

  Fly   974 VRSVGYSDLFVLSKKDMWDVLKEYPA-ARVRLESI----AVKRLEKYKKAPLEKVKYFNVVAMGR 1033
            |:::.|.||..:..|.:::||..||. |...:|.|    .....|.::...:.::.
 Frog   633 VKALTYCDLQCIILKGLYEVLDFYPEYAHTFVEHIQQDLTYNLREGHESDRMSRLS--------- 688

  Fly  1034 CQSTPGLVESCGRTSLEEMWLPPATAGASSLMH-HHQALQQQHQASQQQPH------RQESTQTS 1091
            |:||....:..|..|:...        .||::. ..:..::...:|....|      :.:.:.||
 Frog   689 CKSTLSQTDLRGNGSINNR--------LSSIVEDEDEDTEEDEPSSPSSIHTRNTASKYKKSATS 745

  Fly  1092 SQTHGYSPRSYADRLARATDSP-RSVSPSA----HGSEERPRSRTTSHHSI----------RPQS 1141
            :.:.|.:.:|:...:  ...|| |:.:||:    ..:|....||...::.:          .|..
 Frog   746 NSSLGINLKSFPGTV--PFKSPLRTCNPSSTMARQENEPNLNSRKRENNLMLNLPTVTSLGPPDL 808

  Fly  1142 QPSHTGHICDSSS-------QLECY----GAGVGG---------------AGGGTTPLLG--SHE 1178
            .|.....|.|.:|       ..|.|    .|.:|.               ....|...:|  :||
 Frog   809 SPRVVDGIEDHNSNDEGQAFDFEAYRLRQEARLGQPIREVSDFNPAILFITAEETKQQIGRLNHE 873

  Fly  1179 V--LEDEIKRLRERLHTVES--EN------------------QALNTKLSQQQWDLENRLAEIEM 1221
            |  |..::.:|.:.:.:|.:  ||                  .|:.|.:......::||:.....
 Frog   874 VSSLTQKVSQLGKDMKSVMNILENLLAVQRPVGYYSTYGTVLDAIRTTIGSPMEQIQNRMTWTTN 938

  Fly  1222 QIC-------------------GVSSTSSVDPENETEELERNRESI 1248
            |.|                   .||...::||.:.....:||..:|
 Frog   939 QSCMQRPAETLVGTPTQLCQGAVVSDLWNMDPASVGSSPQRNGSNI 984

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..820	CDD:459842	66/286 (23%)
		CAP_ED	890..1004	CDD:237999	34/115 (30%)
kcnh8	XP_031760363.1	PAS_9	40..135	CDD:463873
		PLN03192	200..>617	CDD:215625	102/435 (23%)
		PRK11753	580..>658	CDD:236969	24/82 (29%)