DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and cnga4

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_017945387.2	Gene:	cnga4 / 100489546	XenbaseID:	XB-GENE-996762	Length:	573	Species:	Xenopus tropicalis

Alignment Length:	459	Identity:	194/459 - (42%)
Similarity:	301/459 - (65%)	Gaps:	6/459 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   565 AARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLID 629
            :.|....:.||||...|.|..::.:...||:.:||.|..|.|:..:.:.:|..||||.|.||::|
Frog    40 STRNRSSILDPAGNWYYCWLNIMVLPVTYNWVIIICRSCFPELQYQYLPVWLSLDYLCDVLYVMD 104

  Fly   630 ILFHFRTGYLEDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFNS-ILRSFRLVKIY 693
            |:.:|.||:||:|:|.||...:..||::|:.|..|.:.:||.||||..:|.:: .:|..|.::.:
Frog   105 IIANFHTGFLEEGILVTDRHLIARHYISSSKFRWDLISVLPTDFLYFKLGIHTPAVRINRFLRFH 169

  Fly   694 RFWAFMDRTERHTNYPNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWVY---HDSESAD 755
            |.:...||||....|||.||...|:.|:.|:.|||.|:|..:....|||...||:   .||:.|.
Frog   170 RLFESFDRTETRIPYPNAFRICKLMAYIFVVIHWNSCVYFALSSFIGFGKDKWVHPNITDSDFAR 234

  Fly   756 VVKQYLQSYYWCTLALTTIGDLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKE 820
            :.:|||.|:|:.||.|||:||:|.|..:.|::|:::..|..::.|||::|.:.::|:::::|.:.
Frog   235 LGRQYLYSFYFSTLILTTVGDIPPPVQEEEWLFMVVDFLIAVLGFATIMGSMTSVVSNMNSADEA 299

  Fly   821 FQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTL 885
            |....|.||.|::|.:|...::.|||.|..:|.:.:|.::|...:..||:||:.|:|::|||..|
Frog   300 FYPNYDNVKLYLKMYKVNRSVKKKVIAWHQHLQIYKKLTNENDILQNLPEKLRVEVAVSVHLPIL 364

  Fly   886 KRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLK 950
            .:|:||||.|...|.||||:|:|.::|||:|:|:||::|:||||:..|:|.||||:|.|..|.|.
Frog   365 SKVQIFQNCEKSLLEELVLKLKPQVYSPGEYVCKKGDIGREMYIIKEGKLAVVADDGVTQFAELG 429

  Fly   951 AGSYFGEISILNM--GTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLE 1013
            .|:|||||||||:  .|:||||||:::|:||||||.|||:|:.|.|:|||.|:..||....:.|.
Frog   430 EGNYFGEISILNIRGNTSGNRRTANIKSIGYSDLFCLSKEDLRDALREYPDAKAILEQKGREILL 494

  Fly  1014 KYKK 1017
            |..|
Frog   495 KMNK 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	91/241 (38%)
		CAP_ED	890..1004	CDD:237999	68/115 (59%)
		DUF4655	1084..>1154	CDD:317882
cnga4	XP_017945387.2	Ion_trans	55..295	CDD:395416	90/239 (38%)
		CAP_ED	369..485	CDD:237999	68/115 (59%)
		CLZ	485..555	CDD:406832	5/14 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45638
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020