Protein Alignment CG42260 and kcnh4

DIOPT Version :10

• Sequence 1: NP_001356969.1
• Gene: CG42260 / 37614
• FlyBaseID: FBgn0259145
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_002942364.2
• Gene: kcnh4 / 100488431
• XenbaseID: XB-GENE-1014062
• Length: 1074
• Species: Xenopus tropicalis
• Alignment Length: 735
• Identity: 161/735 - (21%)
• Similarity: 305/735 - (41%)
• Gaps: 128/735 - (17%)

  Fly   565 AARKLHFVFDPAGRLCYY------WSMVVSMAFLYNFWVIIYRFAFQ------EINRRTIAIWFC 617
            :|.|..|:      |.:|      |..::.:|..|....:.|...|.      ...|.||.
 Frog   206 SAEKPRFI------LLHYSIFKALWDWLILLATFYVAVTVPYNVCFTGHDDSVSAARSTIV---- 260

  Fly   618 LDYLSDFLYLIDILFHFRTGYL-EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLY-LSIGF 680
            .|...:.|::|||:.:|||.|: ..|.:..:...:..||: :|.|::|.:..||.|.|| .::..
 Frog   261 SDIAVEMLFIIDIILNFRTTYVSHSGQVVYETRSICIHYL-ATWFFVDLIAALPFDLLYAFNVTV 324

  Fly   681 NSILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIFHWNGCLYHIIHKN------- 738
            .|::...:.:::.|....:.:.:|::.|..:. .|.|:....::.||..|::::|.:.
 Frog   325 TSLVHLLKTIRLLRLLRLLQKLDRYSQYSAMV-LTLLMSMFALLAHWMACVWYVIGRKEMESNDP 388

  Fly   739 --------NGFGSR---NWVYHDSESADVVKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFVIL 791
                    :..|.|   .::.:......:...|:.|.|:...:||::| ......:..|.:|.|.
 Frog   389 VTWDIGWLHELGKRLEAPYINNSIGGPSIRSAYIASLYFTLSSLTSVGFGNVCANTDAEKIFSIC 453

  Fly   792 QLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQ 856
            .:|.|.::.|.|.|:|..|:..:.:.|..:..::..:|.::|:..:|..|:.:.:::|...|...
 Frog   454 TMLIGALMHAVVFGNVTAIIQRMYSRRSLYHTRVKDLKDFIRVHCLPQQLKQRTLEYFQTTWSVN 518

  Fly   857 KCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKG 921
            ...|....:...||:|:|:||::::.|.| ::.:|:....|.|..|.|.::....:||:|:.|:|
 Frog   519 NGIDANELLKDFPDELRADIAMHLNKDIL-QLSVFETASRGCLRALSLHIKTSFCAPGEYLLRQG 582

  Fly   922 EVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFG-EISILNMGTAGNRRTASVRSVGYSDLFVL 985
            :..:..|.|..|.|:|:.||  .|:|.|..|...| ::|..:.....|   |.|:::.|.||..|
 Frog   583 DALQANYFVCSGSLEVLKDN--MVLAILGKGDLIGADLSNKDQVIKTN---ADVKALTYCDLQYL 642

  Fly   986 SKKDMWDVLKEYP-----------------------------------AARVRLESIAV--KRLE 1013
            |.:.:.:||:.||                                   .::.|.||.|.  |:|.
 Frog   643 SLRGLLEVLELYPEYCNKFRADIHHDLTFNLREGSETNGCYRFSRSPRLSQPRPESGATPEKKLA 707

  Fly  1014 KYKKAPLEKVKYFNVVAMGRCQSTPGLVESCGRTSLEEMWLP----PATAGA-SSLMHHHQALQQ 1073
            ...:...|...||.              .|....:..::.||    |...|: |||:  ...|:|
 Frog   708 SILEDNDETDDYFR--------------HSPASMTRRKLMLPNLNSPIRRGSLSSLL--GDELRQ 756

  Fly  1074 QHQASQQQPHRQESTQTSSQTHGYSPRSYADRLARATDSPRSVSPSAHGSEERPRSRTTSHHSIR 1138
            .|      ..|:.........||.||.....:..|..|:..|..|:   :...|...|.:..::.
 Frog   757 FH------AFRRNCRSPGRTNHGRSPSPQCRKAERVIDTEGSHKPA---NLLIPALNTYAPPNLS 812

  Fly  1139 PQ--SQPSHTGHICDSSSQLECYGAGVGGAGGGT--TPLLG---SHEVLEDEIKRLRERLHTVES 1196
            |:  .....:|.|  |.||...:......|...|  :|..|   .:.:|..|.:.:::.:..:..
 Frog   813 PRVVDGIEDSGDI--SESQTFQFNVDNSRARSPTRQSPPAGVKVMNPILAAEAEEIKQNICRLNL 875

  Fly  1197 ENQALNTKLSQQQWDLENRL 1216
            |...||.::||...:|::.:
 Frog   876 EINNLNQEVSQLSKELQHMM 895

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..820	CDD:459842	58/271 (21%)
		CAP_ED	890..1004	CDD:237999	35/149 (23%)
kcnh4	XP_002942364.2	PAS_9	40..135	CDD:463873
		PLN03192	224..>615	CDD:215625	93/399 (23%)
		PRK11753	578..>656	CDD:236969	26/82 (32%)