DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and LOC100334711

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_002660423.1	Gene:	LOC100334711 / 100334711	-ID:	-	Length:	718	Species:	Danio rerio

Alignment Length:	458	Identity:	221/458 - (48%)
Similarity:	305/458 - (66%)	Gaps:	14/458 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   571 FVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFR 635
            ::.|||..|.|:|..:|::...||..:::.|..|.|:......:|..|||.||.:|.:|.....|
Zfish   190 WIMDPATDLYYHWLTIVAIPVFYNLMLLVTRACFNELQDDYTILWMVLDYTSDVIYYLDTFVRSR 254

  Fly   636 TGYLEDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFNS-ILRSFRLVKIYRFWAFM 699
            ||:||.|:|..::.||..||..|..|..|...::|.|.|.|.:|:|: .||..||.|:.|.:.:.
Zfish   255 TGFLEQGLLVRESKKLWEHYKKSPQFKFDIFSMIPTDILMLKVGYNNPELRFNRLFKMARLFEYF 319

  Fly   700 DRTERHTNYPNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWVY---HDSESADVVKQYL 761
            ||||..||:||:||.:.|:.|:|:|.|||||::..|.|..||||.:|||   .|.|...:.::|:
Zfish   320 DRTETRTNFPNIFRISNLVLYILIIIHWNGCIFFAISKTLGFGSDSWVYPNISDPEFGRLGRKYI 384

  Fly   762 QSYYWCTLALTTIGDLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLD 826
            ...||.||.|||||:.|.|....||.||:...|.|:::|||::|:|..::::::|:|.|||||:|
Zfish   385 YCLYWSTLTLTTIGETPPPVRDIEYFFVVSDFLIGVLIFATIVGNVGAMISNMNASRAEFQAKID 449

  Fly   827 GVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIF 891
            .:|.||:.|:|...|:.:|:|||||||..||..||:..:..|||||||||||||||:||::|.||
Zfish   450 SIKQYMQFRKVSKDLEARVVKWFDYLWTEQKTCDEKEVLKYLPDKLKAEIAINVHLETLRKVRIF 514

  Fly   892 QNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFG 956
            |:.|||.|.||||:|:|.:||||||||:||::|:||||:..|:|.||||:|.|....|..|:|||
Zfish   515 QDCEAGLLVELVLKLQPQVFSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGAYFG 579

  Fly   957 EISILNM--GTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAP 1019
            |||||.:  ..|||||||::|||||||||.|||.|:.|.|.|||.|:        |.||:..:|.
Zfish   580 EISILGIKGSKAGNRRTANIRSVGYSDLFALSKDDLMDALSEYPEAK--------KALEEKGRAI 636

  Fly  1020 LEK 1022
            |.|
Zfish   637 LMK 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	96/241 (40%)
		CAP_ED	890..1004	CDD:237999	72/115 (63%)
		DUF4655	1084..>1154	CDD:317882
LOC100334711	XP_002660423.1	Ion_trans	228..441	CDD:278921	88/212 (42%)
		Crp	507..697	CDD:223736	81/141 (57%)
		CAP_ED	513..629	CDD:237999	73/123 (59%)
		CLZ	629..699	CDD:293134	5/11 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5401
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	O	PTHR45638
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920