DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42260 and HCN4

DIOPT Version :10

Sequence 1:NP_001356969.1 Gene:CG42260 / 37614 FlyBaseID:FBgn0259145 Length:1269 Species:Drosophila melanogaster
Sequence 2:NP_005468.1 Gene:HCN4 / 10021 HGNCID:16882 Length:1203 Species:Homo sapiens


Alignment Length:883 Identity:217/883 - (24%)
Similarity:354/883 - (40%) Gaps:186/883 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   409 KSRGRLKTAASGDQPLLGTWNRSTG------RGSQDNTLAGGGATSLAMGGHNQYG--------- 458
            :||.....||..:.|..|....||.      |||..:..:.||.:. ..|..:.:|         
Human    66 ESRSSALGAADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGGSG-GTGSGSSHGHLHDSAEER 129

  Fly   459 -----GNYCNGTDRYPRSRSQQQGHHNAAQQAHHPYQLQHSASTVSHHPHAHGPPSQGGPGGPGP 518
                 |:...|.||.|...:.:.....|:.|                 |.|..||    |..|..
Human   130 RLIAEGDASPGEDRTPPGLAAEPERPGASAQ-----------------PAASPPP----PQQPPQ 173

  Fly   519 PHGGHPHHPH-------HGGAGSG-----------GGSG-----------PGSH-------GGQP 547
            |.......|.       .|||.:|           |.:|           ||.:       |.  
Human   174 PASASCEQPSVDTAIKVEGGAAAGDQILPEAEVRLGQAGFMQRQFGAMLQPGVNKFSLRMFGS-- 236

  Fly   548 HHQKPRRTASQRIRAATAARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTI 612
              ||......:|:::|.     .::..|.....:||.:.:.:..:.|..:|.....|.:....| 
Human   237 --QKAVEREQERVKSAG-----FWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTT- 293

  Fly   613 AIWFCLDYLSDFLYLIDILFHFRTG-YLEDGV-LQTDALKLRTHYMNSTIFYIDCLCLLPLDFLY 675
             .|...:.:||..:|||::.:|||| .:||.. :..|..:::..|:.|. |.:|.:..:|:|:::
Human   294 -PWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSW-FMVDFISSIPVDYIF 356

  Fly   676 L------------------SIGFNSILRSFRLVKIYRFWAFMDRTER--HTNY---PNLFRSTAL 717
            |                  .:.|..||...||:::.|...::.:.|.  |..|   ..:.|...|
Human   357 LIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNL 421

  Fly   718 IHYLLVIFHWNGCLYHIIHKNNGFGSRNWV-YHDSESADVVKQYLQSYYWCTLALTTIG-DLPKP 780
            |..:|::.||:|||..::.....|....|| .::..:....|||..:.:.....:..|| ....|
Human   422 IGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAP 486

  Fly   781 RSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKV 845
            ....:....:|.::.|...:|..:||...::.|:.::|:::|.|...|:.||...::|...:.::
Human   487 VGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRI 551

  Fly   846 IKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTL-KRVEIFQNTEAGFLCELVLRLRPV 909
            ..::::.: ..|..|||..:..|.:.|:.|| ||.:...| ..:.:|.|.:..|:..::.:||..
Human   552 HDYYEHRY-QGKMFDEESILGELSEPLREEI-INFNCRKLVASMPLFANADPNFVTSMLTKLRFE 614

  Fly   910 LFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASV 974
            :|.|||||.|:|.:||:||.:..|.:.|:....|.  ..|..|||||||.:|..|    ||||||
Human   615 VFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKE--TKLADGSYFGEICLLTRG----RRTASV 673

  Fly   975 RSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAP---LEKVKY------FN--- 1027
            |:..|..|:.||..:..:||:|||..|...|::|:.||::..|..   |.||::      ||   
Human   674 RADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQE 738

  Fly  1028 ------VV----AMGRCQSTPGLVESCGRTSLEEMWLP---------PATAGASSLMHHHQALQQ 1073
                  :|    .|..|........|...|....:|.|         .||...:..:.||..|  
Human   739 NEIIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRL-- 801

  Fly  1074 QHQASQQQPHRQESTQTSSQTHGYSPRSYADRLARATDSPRSVSPSAHGSEERPRSRTTSHHSIR 1138
              .|:..:|  ...:...:...|.:|| :..||       :|:.|||.||..             
Human   802 --PAAIFRP--PPGSGLGNLGAGQTPR-HLKRL-------QSLIPSALGSAS------------- 841

  Fly  1139 PQSQPSHTGHICDSSSQLECYGAGVGGAGGGTTPLLGS 1176
            |.|.||.......||..::.. ||. .|..|.:|||.|
Human   842 PASSPSQVDTPSSSSFHIQQL-AGF-SAPAGLSPLLPS 877

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42260NP_001356969.1 Ion_trans 581..820 CDD:459842 60/265 (23%)
CAP_ED 890..1004 CDD:237999 47/113 (42%)
HCN4NP_005468.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..182 29/137 (21%)
Involved in subunit assembly. /evidence=ECO:0000250 209..260 10/59 (17%)
Ion_trans_N 218..260 CDD:400630 8/50 (16%)
PLN03192 253..>740 CDD:215625 135/497 (27%)
CAP_ED 595..703 CDD:237999 47/113 (42%)
PHA03247 <766..1044 CDD:223021 35/141 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 836..856 7/32 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 870..897 5/8 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 918..1203
PHA03247 <928..1200 CDD:223021
Blue background indicates that the domain is not in the aligned region.

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