DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and kcnh4a

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_001309362.1	Gene:	kcnh4a / 100148126	ZFINID:	ZDB-GENE-131125-34	Length:	1151	Species:	Danio rerio

Alignment Length:	816	Identity:	173/816 - (21%)
Similarity:	314/816 - (38%)	Gaps:	193/816 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   565 AARKLHFVFDPAGRLCYY------WSMVVSMAFLYNFWVIIYRFAFQ------------EINRRT 611
            :.:|..|:      |.:|      |..::.:|..|....:.|...|.            :.:.||
Zfish   204 SVQKSRFI------LLHYSVCKAMWDWLILLATFYVAVTVPYNVCFSTPDDSQLDSPDCDSSSRT 262

  Fly   612 IAIWFCLDYLSDFLYLIDILFHFRTGYL-EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLY 675
            ..:   .|...:.|:::||:.:|||.|: ..|.:..|...:..||. :|.|.:|.:..||.|.||
Zfish   263 TIV---SDIAVEMLFILDIILNFRTTYVGPAGQVVYDTRSICLHYC-TTWFILDLIAALPFDLLY 323

  Fly   676 L-SIGFNSILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCLYHII 735
            | :|...|::...:.|::.|....:.:.:.::.|     |..::..|:.:|    ||..|::::|
Zfish   324 LFNISVTSLVHLLKTVRLLRLLRLLQKLDGYSQY-----SAVVLTLLMSVFALLAHWLACVWYVI 383

  Fly   736 HKNNGFGSRNWVYHDSESADV------------------------VKQYLQSYYWCTLALTTIG- 775
                  |.:....:|..:.|:                        ...|:.|.|:...:||::|
Zfish   384 ------GRQELASNDPLTWDIGWLQELGKRLETPYTNGTVGGPSLRSAYIASLYFTLSSLTSVGF 442

  Fly   776 DLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNH 840
            ......:..|.:|.|..:|.|.::.|.|.|:|..|:..:.:.|..:..::..:|.::|:.|:|..
Zfish   443 GNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHTRMKDLKDFIRVHRLPQQ 507

  Fly   841 LQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLR 905
            |:.:::::|...|......:....:...||:|:|:||::::.|.| ::.:|.:...|.|..|.|.
Zfish   508 LKQRMLEYFQTTWSVNNGINANELLHDFPDELRADIAMHLNKDIL-QLPLFSSASRGCLRSLSLH 571

  Fly   906 LRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGN-- 968
            ::....:||:|:.|.|:.....:.|..|.|:|:.|.  .|:|.|..|...|      ....|.
Zfish   572 IKTSFCAPGEYLIRHGDALHAQHFVCSGSLEVLKDG--MVLAILGKGDLVG------ADLPGKDQ 628

  Fly   969 --RRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRL-ESI----------AVKRLEKYKKAPL 1020
              :..|.|:::.|.||..:|.:.:.:||:.||....|. |.|          ...|..:..:...
Zfish   629 VIKANADVKALTYCDLQYISVRALQEVLELYPEYGSRFNEDIHHNLTYNLREGQARFSRSTRLAQ 693

  Fly  1021 EKVKYFNVVAMGRCQSTPGLVES---------CGRTSLEEMWLPPATAGASSLM-----HHHQAL 1071
            ||        ...|: .|.:||:         .||..|...:..|::....|.|     .||..|
Zfish   694 EK--------FDECK-LPFIVETEQEDDTGQDLGRRPLLSGFSCPSSQSNLSAMLGEEFRHHNML 749

  Fly  1072 -------QQQHQASQQQPHRQESTQTSS---QTHGYSPRSYADRLARATD--SPRSVSPS-AHGS 1123
                   |.....|.|.|..:|.|..|:   :|...|....|..|....:  ||..:||. ..|.
Zfish   750 RFCRSPVQSSRIQSPQIPLHEEQTTASAPVPKTDKISCNRPAKLLIPTLNCVSPLDLSPRVVDGI 814

  Fly  1124 EERPRS-RTTSHHSIRPQSQPSHTGHICDSSSQLECYGAGVGGAGGGTTPLLGSHEVLEDEIKRL 1187
            |:...: .....||..|.::......:                         |::.:||.|  .:
Zfish   815 EDNEHAFHFNVEHSESPNTEVKDPFQV-------------------------GANLLLETE--EV 852

  Fly  1188 RERLHTVESENQALNTKLSQQQWDLENRLAEIEMQI-------------CGVSS------TSSVD 1233
            |:.|..:.:|...||.:::....:|...:..:...:             |..||      ||:.|
Zfish   853 RQSLRQLNTEMNHLNQEVTSLTKELHEMMQFLHAHVTQPHFPSSFTPFACHTSSNCTSVATSTTD 917

  Fly  1234 ------------PENETEELERN----RESIIXHGS 1253
                        |..:.|...|:    |.|.| .||
Zfish   918 WPSRLSYSMPSGPCLQAEPSRRDSFTPRHSCICSGS 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	60/286 (21%)
		CAP_ED	890..1004	CDD:237999	31/117 (26%)
		DUF4655	1084..>1154	CDD:317882	16/76 (21%)
kcnh4a	NP_001309362.1	PAS	42..133	CDD:238075
		PAS_3	42..127	CDD:285623
		Ion_trans	267..486	CDD:278921	52/230 (23%)
		Ion_trans_2	<426..480	CDD:285168	16/53 (30%)
		Crp	553..745	CDD:223736	47/208 (23%)
		CAP_ED	556..666	CDD:237999	31/117 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910