DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and kcnh8

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_017207899.2	Gene:	kcnh8 / 100002967	ZFINID:	ZDB-GENE-060503-204	Length:	975	Species:	Danio rerio

Alignment Length:	695	Identity:	159/695 - (22%)
Similarity:	302/695 - (43%)	Gaps:	101/695 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   569 LHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAF---QEINRRTIAIWFCLDYLSDFLYLIDI 630
            |||....||     |..::.:|..|....:.|...|   |::.|.|..    .|...:.|::|||
Zfish   212 LHFSTFKAG-----WDWLILLATFYVAVTVPYNVCFIGDQDLTRSTTV----TDIAVEILFIIDI 267

  Fly   631 LFHFRTGYL-EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYL----SIGFNSILRSFRLV 690
            :|.|||.|: :.|.:..||.::..||| :|.|.||.:..||.|.||.    .:....:|::.||:
Zfish   268 VFSFRTTYVSKSGQVIFDARQICIHYM-TTWFIIDLVAALPFDLLYAFKVSVVSVVHLLKTVRLL 331

  Fly   691 KIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCLYHIIHK-----NNGFGSRNW 746
            ::.|....|||..:|        ||.::..|:.:|    ||..|:::||.|     |.......|
Zfish   332 RLLRLLQKMDRYSQH--------STVVLTLLMSMFALLAHWMACIWYIIGKKEVESNADTWDIGW 388

  Fly   747 VYH-----DSESADVVKQ-----------YLQSYYWCTLALTTIG-DLPKPRSKGEYVFVILQLL 794
            ::.     :|....|..:           |:.:.|:...:||::| ......:..|.:|.|..:|
Zfish   389 LHELGKRLESPYEGVANRTLSSGPSLRSIYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTML 453

  Fly   795 FGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCS 859
            .|.::.|.|.|:|..|:..:.:....:..:...:|.::|:..:|..|:.:::::|...|......
Zfish   454 IGALMHALVFGNVTAIIQRMYSRWSSYHTRTKDLKDFIRVHHLPQSLKQRMLEYFQTTWSVNNGI 518

  Fly   860 DEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVG 924
            |....:...||:|:::||::::.:.|: :.:|.:...|.|..|.|.::....:||:|:.|:|:..
Zfish   519 DSNELLRDFPDELRSDIAMHLNKEILE-LSVFSSLSRGCLRSLSLHIKTSFCAPGEYLLRQGDAL 582

  Fly   925 KEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFVLSKKD 989
            :.::.|..|.::|:.||  .|:|.|..|...|  :.:::|....:..|.|:::.|.||..::.:.
Zfish   583 QALFFVCSGSMEVLKDN--MVLAILGKGDLIG--ANMSVGDRVIKTNADVKALTYCDLQCINLRG 643

  Fly   990 MWDVLKEYPAARVRLESIAVKRLEKYKKAPLEKVKYFNVVAMGRCQSTPGLVESCGRTSLEEMWL 1054
            :::||..||....|.    |:.:.......|.:.:..:|::....:|....:|..|.....:.:.
Zfish   644 LYEVLDLYPEYSHRF----VQDITHDLTYNLREGQESHVISRMSSKSMDTQMEGRGNGDAIQCYP 704

  Fly  1055 PPATAGASSLMHHHQ-----------ALQQQHQASQQQPHRQEST-QTSSQTHGYSPRSYADRLA 1107
            |.|.       ||::           .:|......:|:.|.|::. ||:.:.|..........|.
Zfish   705 PIAE-------HHNEEDDDDDDDEDDQIQYLSGGGKQKTHMQKNDHQTNKKLHIQHTTVTKPDLG 762

  Fly  1108 RATDSPRSVSPSAHGSEERPRSRTTSHHSIRPQSQPSHTGHICDSSSQLECYGAGVGGAGGGTTP 1172
            ..  |||.|.    |:|:            ...::.||| .|..|:.|....||  ......|..
Zfish   763 NL--SPRVVD----GTED------------SDGTENSHT-FIFSSAHQHSVSGA--TNTTATTAE 806

  Fly  1173 LLGSHEVLEDEIKRLRERLHTVESENQALNTKLSQQQWDLENRLA 1217
            |....|....:::.|.:.:.::..|...|...:....:.:|:.:|
Zfish   807 LAAKSEDTRGQLRHLNQEVSSLGREVAELGRVMRSLAFLIESMMA 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	70/271 (26%)
		CAP_ED	890..1004	CDD:237999	30/113 (27%)
		DUF4655	1084..>1154	CDD:317882	16/70 (23%)
kcnh8	XP_017207899.2	PAS_9	36..131	CDD:315989
kcnh8	XP_017207899.2	Ank_2	193..>620	CDD:330894	109/430 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910