DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30268 and CFAP61

DIOPT Version :9

Sequence 1:	NP_611712.2	Gene:	CG30268 / 37610	FlyBaseID:	FBgn0050268	Length:	1240	Species:	Drosophila melanogaster
Sequence 2:	XP_005260745.1	Gene:	CFAP61 / 26074	HGNCID:	15872	Length:	1242	Species:	Homo sapiens

Alignment Length:	1409	Identity:	309/1409 - (21%)
Similarity:	550/1409 - (39%)	Gaps:	381/1409 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RRIE--DLYDAKSTWH-FGVKETPPLDTLFLKNQAQRLIVY--NKQEYHLLLAYSEFANHPNIPV 78
            ||.|  |:|..||... |..|....|:.::|..:|...:..  :|:|   ::|.:.|.::||..|
Human    17 RRTESQDVYCIKSLIRKFTCKLFGKLNIIYLLEKANLAVTLCNDKEE---IMAQATFLDYPNWNV 78

  Fly    79 LANDLWLHWLNV--RFCVDLPITLLNAIFFNFFICKDGHSQMLKKVILEVFYTE----HLVNYML 137
            ...|   .|::|  ....|:|.|.||.:|.:.|:..|.:|....|.||...|..    |.: :::
Human    79 AKQD---DWVSVFRELDSDIPCTPLNTLFMHLFVAVDEYSVGCCKEILRTVYKAVPELHFI-FLI 139

  Fly   138 VFKPPDCPPGQYDAVQAFGTTYYPKHSKVSEQKHLP--------AVIVIQRRSTMPVLSFRKALP 194
            |           .:..:.|:|......:|.   ::|        ||.:..|.|..|.|..|||..
Human   140 V-----------PSYMSLGSTLITVFDQVG---NIPCLTYEEDFAVHICHRHSHYPQLHVRKARV 190

  Fly   195 EDNDDIVEMIDSEDPELRKKHGDFYIAEHLLNAEGSDSDHNDKIIIAEFEEEIADNVKGAGLMWL 259
            ||:||::.:....|..|::.:|::::|| |:.|:    |..:..::.|.|.      ...|.|.:
Human   191 EDHDDLMPIFMRYDTILKETYGEYFLAE-LIEAQ----DEENHAVVCEVEG------TAVGFMSV 244

  Fly   260 SQSLDIKMLATNYHLERLGNLVRYTPGCTHAHVGFEVISVELKSYKELFTRKQMEERYKSHVSRI 324
            ...:::::|...:.|.....|....|...            |:|.::|..|:..:...:|
Human   245 CSRVNMQLLHECFDLGPFHGLCFPHPDDV------------LESPQDLSVRRSQDAELRS----- 292

  Fly   325 NTDGQDETRNILFKKYKHIYEELREGV-------------------YYITAHQ-------DKLEI 363
            ::.|..:           |.|||:|.|                   ..:||.|       :.:|.
Human   293 SSQGSQK-----------IVEELQEPVSPDTMENIQGNIAREAASEEALTAVQSGNVSEPEDIEK 346

  Fly   364 SFDLPDGEKSTSENRLQYLAK----------------ASNGFLLKMFQLHPLVRYEYTFYSLSAM 412
            ..|:..|.........:.||.                ||..|.:::|    .:..:|...||..|
Human   347 LSDISTGYAQYHHVSSRSLASLVLPEEPVHFRPIYRGASAAFCIQLF----CIDEKYEARSLDFM 407

  Fly   413 ---FSAFPDHDYCVTLVPANVSTSPCQRELLRFFLPVAHRPSSTVSENLFVAHRSTLFGELRVHR 474
               ||.|.|.::||..:|   ..:| :..|::.|:.:....:.|:.::|:|.||:.|...:.: |
Human   408 NFVFSLFSDKNFCVISLP---HLTP-EFFLIQNFVKMVPFNTCTLEQDLYVFHRAGLLKSINI-R 467

  Fly   475 FESQEIDEIRTLISKQARKRESLSEDDSEDSKGIDNYTEDVL---SIFEDIIR--EILEDPMCD- 533
            |        .||:                |:.|::|....::   ||.||:.|  :..:||  |
Human   468 F--------ATLL----------------DTPGVENLVSTLMLNKSILEDLDRYNKARKDP--DG 506

  Fly   534 --LTCFTIRCGQSKKHTDCPLVGFIILRPFLVYDDISKIFMMPRDQFSLT-------HKR---GE 586
              |..|.....:.       :||..::|..:   ||..|    |..:::.       |:|   |.
Human   507 TLLQAFVAEVAEQ-------IVGIAVIRNEM---DIEYI----RSHYNIEDFIYFSHHQREEHGH 557

  Fly   587 IVMFRLHPFFQMWCKTILRTV-----ALCDNYRELY----------------YIHFFSGISLPND 630
            :..|.|:|.|:.:.|..|:.:     ..|..|| :|                |.|     ||.:.
Human   558 MHHFALNPIFRHYTKFFLKEILRLGFKSCLYYR-VYPKSREGKIAVFQFQNPYAH-----SLTSA 616

  Fly   631 LMYNMMPIEPRR-----MKKNLFNYKCVSLRRRVAKGKMSVNVSMDICTSRMRLFCHNLQPTMHM 690
            |.| ::|:.|||     ::|...|    :..:.|:|..||..::.   |:|..    .|:|.:.:
Human   617 LHY-LVPVRPRRQIVYPLEKLGIN----APSKAVSKDPMSYALNH---TNRKL----TLEPKITV 669

  Fly   691 GGKNSLLIVGFSSTCMAFLRTVIFAWNSKDLINYKKYNCLPMVDITVLVGHGIIESAYDCDFSCN 755
            ..|  :::||.||..::||.|::|.       ::.|:|.|.::....|.|..::::......:.:
Human   670 NAK--IIVVGASSVGISFLETLVFC-------SHMKFNNLTLISTHGLPGKKLLDTEQRKFLASD 725

  Fly   756 FCANARNCYVDTGNVNPFVRDTMQRMDVRHWVRFVSGEVKSIKRQEKVVELSDGCHLYYDKLVLM 820
            .|.|.::..:               |.:..||..|.|.:..|.|..|.|.||....:.||.|:|.
Human   726 HCFNDKDYAL---------------MSLCSWVNVVVGRMTGIDRAAKHVVLSTDEIVPYDHLILC 775

  Fly   821 GATRY--------------------GFEDKEFKGHPIPLNYVVNNTRLD---RIIFYHKVCEMVE 862
            ...:|                    ....:.:.| .:|.|:...|...|   .:|:...    ..
Human   776 TGQQYQVPCPTEADISQHLTNREVPNSSQRRYTG-KVPCNHFTLNEEEDCFKALIWIRN----NS 835

  Fly   863 LMESYYIIVYGYNLCIYECIHFLVTHGCKAQNIIYVQPHVPIVMEDLGIPEKDSRLDPIILEMIA 927
            :.....|||||..:..|..:..|:..|.....|..|||.....:..:    .:..::..:.:.:.
Human   836 ITTEGNIIVYGNTIDTYTTVETLLNLGVSGSRIHLVQPPPASTITCI----NNYSVESAVADALG 896

  Fly   928 DLGVTIYLSTNYSQFILSQDNMNIEKVELIMHPS----------KKKIVLHCDLFVNYNDNTISS 982
            ..|||:|...     ||:|.|..       :||.          .|...|.|.:|.::.:..:..
Human   897 AAGVTMYRDA-----ILAQWNDG-------LHPDPIYSASFTTPTKPFRLQCSMFFSFCEKNVDY 949

  Fly   983 SMENVLSEAGIEISERRIVVNSRYCTNDRNIFAAGINVIMIPKPNFQY-----TYG--SPQEMAE 1040
            .....|::|.: :.:.|:|:::.:.|||..|.|||    .:.|.:.:|     |:.  |.:|:..
Human   950 ETFKALNDACL-VYDSRLVIDTNFHTNDIAIRAAG----SLTKFSNRYYSNEWTHSNFSSKEIGF 1009

  Fly  1041 KLAYEL----------------NMIKVVMQSRYSKPYMFTGILPMGYQIIKITQ---PKPLLIGQ 1086
            :||..:                |:.:::...:.:|  :..||||..|..:.|.:   |.||.:..
Human  1010 QLAAAMLHLFDPTLEPVTEPPANLDRLIPMYKGAK--IQGGILPGSYHYLHIAKPAIPTPLEVQM 1072

  Fly  1087 LPIEFSETLTT--YDDGDFCRIRLNNKLIVIEIVCVTKKP------KRLYFMEYFCGKHAMLLND 1143
            ....:...|.|  ..:|.:.||.:|...:|..|.|::::|      .||:      |:|..|||:
Human  1073 AQPNYGLELVTGSAKNGTYFRIHINKYKMVETITCLSREPFPASNYIRLF------GQHEQLLNN 1131

  Fly  1144 LRGRFQAGWIQNFLDFFQQPWTELLMHDRFEDLQLKNRRLLLS----------MLLMNNKD---- 1194
            |..|:....|.:...:|.:||...|.||||.||:.:.|::|.|          .|....:|
Human  1132 LCARYDENLITDLYSYFTEPWCLALFHDRFIDLRKELRQILASKEEEDLPSIEQLAHQIEDEEIN 1196

  Fly  1195 -TNNPRNSL-----ENTQRLRLEENVIDFVRTYRKDFTHEFALP 1232
             |..||..|     |:..:..:|.:.:|::. |.:.....:|.|
Human  1197 PTEKPRQYLKRVFEESIYKTLVERSTLDYLH-YNRYHLPMYAWP 1239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30268	NP_611712.2	DUF4821	14..286	CDD:292710	69/285 (24%)
CG30268	NP_611712.2	Pyr_redox_2	<793..1017	CDD:285266	52/256 (20%)
CFAP61	XP_005260745.1	DUF4821	15..268	CDD:318340	69/282 (24%)
CFAP61	XP_005260745.1	NirB	672..>777	CDD:330997	31/128 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159855
Domainoid	1	1.000	116	1.000	Domainoid score	I5960
eggNOG	1	0.900	-	-		E1_2CMWM
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I4187
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57462
OrthoDB	1	1.010	-	-		D120508at33208
OrthoFinder	1	1.000	-	-		FOG0009665
OrthoInspector	1	1.000	-	-		otm40963
orthoMCL	1	0.900	-	-		OOG6_104363
Panther	1	1.100	-	-	O	PTHR21178
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5804
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.890