Protein Alignment CG30259 and DRC2

DIOPT Version :10

• Sequence 1: NP_611708.2
• Gene: CG30259 / 37606
• FlyBaseID: FBgn0050259
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_149115.2
• Gene: DRC2 / 85478
• HGNCID: 29937
• Length: 484
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 134/505 - (26%)
• Similarity: 256/505 - (50%)
• Gaps: 52/505 - (10%)

  Fly     8 KGNKLAN--MSEEERARYLQMRADMEEETRRRKMQLISMYMKNKLKREDAFGRLNMAKINQEWRS 70
            |..|:|.  :|:|::....|.:...|||..::|.:|:|.::|:||.:|:....||:.|||.:||:
Human     3 KKEKMAKTPLSDEKQLLLFQQKLLAEEEMAKKKERLLSQFLKDKLAKEEHNSALNLNKINTQWRT 67

  Fly    71 ILRQVKIQELRREIVDVESFFQEALKRKDQVIHRLIAHIESTEDMYANLQQSHMENITRIVDTHR 135
            :||:||.:||.::|..:...|:..:..||.||..|...:...|:.||:..:||:.|:.:::...|
Human    68 VLREVKTRELHKDIEILSQTFERVVDCKDNVIKSLAKDLSEAEEQYAHALRSHLHNVDQLLALQR 132

  Fly   136 DRIEFFRTIYEDDKQAVLSQWEQDSAAFKEMHAQKQQQLECVFYQLEENTDGGIRDNHERFLDRC 200
            .|:......|..:.:|:..::|.:.....:.|.::...|:.:|..:|:|......::...|....
Human   133 HRLSLLEESYNMELEALTKEFETERKTIIDQHEKEIHYLQDIFMAMEQNYIDSEYESKLEFQSMW 197

  Fly   201 EDLKSGMQLQLEQ---ITSRGEARLEKLWQEYQGVLAGYCQHIEGFYSEYVDLKQRDEEAALQIS 262
            .|||:   :.||:   :....|.|:|.||:::|.||..|....|...:.:..|:.:||:::.:|.
Human   198 NDLKN---MNLEEKHFLRLHLENRVEDLWRKFQDVLKNYTDATEDRKAAFETLQVKDEKSSKEIE 259

  Fly   263 QQTHEIEHLVDQLT----NLRLVSEEF-----YIKQQGQLEQRQAIKQQLTERLRELRTCVEQEV 318
            .|..:|:.|.|.:|    .:.:.|.|.     ||:..         |:.:..:||:|:....|..
Human   260 VQMKKIQKLQDAITISKGKIMIHSRESEDENRYIRND---------KELVLVQLRKLKAQRTQAR 315

  Fly   319 ARDHQLFKLMSVESYHALEFLQETVAKGETLAQLSAVCAKMETQRERMFQLPEIS-------KEI 376
            |...:....:::||...|:.|::.|.|||.:.:|:.:|.|.||:.|::  ||..|       :|.
Human   316 AASQKNLVRLTLESNATLKALRKIVDKGEKILKLAEICRKFETEEEKV--LPFYSSVLTPKEQEG 378

  Fly   377 IEIRDIEDQGNGSLTDPATDLLKDEVAVVPQMESFWRRVNNVAVDVACLKQQKRRLEAENSQLKT 441
            |:..::|:     ||:..|.::.|.:.    ||:||:|.|.|.::...|:.::.:|...|.:|:.
Human   379 IQKNNLEE-----LTEELTKVMVDYIG----MENFWKRYNKVKLEQLSLQHRRAQLLDINGKLRE 434

  Fly   442 QLQDYLVNLNIANGSNSHVHSYLARRPKSMSVDRVSRLQLQPKLVKSAQP 491
            .|:.||..:::::       ..|::......|:..|.| |||..::.|.|
Human   435 MLKQYLDGISVSD-------EVLSQLNPLFIVNYQSNL-LQPLSIRIAHP 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30259	NP_611708.2	NYD-SP28	26..127	CDD:464307	35/100 (35%)
		SMC_prok_B	47..>376	CDD:274008	92/347 (27%)
DRC2	NP_149115.2	NYD-SP28	27..124	CDD:464307	35/96 (36%)