DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment robo1 and BOC

DIOPT Version :9

Sequence 1:	NP_476899.1	Gene:	robo1 / 37603	FlyBaseID:	FBgn0005631	Length:	1395	Species:	Drosophila melanogaster
Sequence 2:	XP_016862930.1	Gene:	BOC / 91653	HGNCID:	17173	Length:	1118	Species:	Homo sapiens

Alignment Length:	891	Identity:	217/891 - (24%)
Similarity:	328/891 - (36%)	Gaps:	196/891 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LPAW--------LLLVLVASNGLPAVRGQYQSPRIIEHPTDLVVKKNEPATLNCKVEGKPEPTIE 88
            :.||        |..:|:|:.|..|...:.  |::...|...|.|......|.|.|| .|...:.
Human     6 MTAWRGMRPEVTLACLLLATAGCFADLNEV--PQVTVQPASTVQKPGGTVILGCVVE-PPRMNVT 67

  Fly    89 WFKDGEPVSTNEKKSHRVQFKDGALFFYRTM--QGKKEQDGGEYWCVAKNRVGQAVSRHASLQIA 151
            |..:|:.::.::...       |.|..:.|:  ........|.|.|||:...|...|..|::.:|
Human    68 WRLNGKELNGSDDAL-------GVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLA 125

  Fly   152 VLRDDFRVEPKDT-RVAKGETALLECGPPKGIPEPTLIWIKDGVPLDDLKAMSFGASSRVRIVDG 215
            .|: ||:::.:.. .|.:|.||::.|..|:..|:..   ::..|..:.|:|    :.....|:..
Human   126 NLQ-DFKLDVQHVIEVDEGNTAVIACHLPESHPKAQ---VRYSVKQEWLEA----SRGNYLIMPS 182

  Fly   216 GNLLISNVEPIDEGNYKCIAQNLVGTRE----SSYAKLIVQ------VKPYFMKEPKDQVMLYGQ 270
            |||.|.|....|||.|||.|.|.| |:|    .|..:|.|:      .:..:..|.:..::..||
Human   183 GNLQIVNASQEDEGMYKCAAYNPV-TQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQ 246

  Fly   271 TATFHCSVGGDPPPKVLWKKEEGNIP-VSRARILHDEKSLEISNITPTDEGTYVCEAHNNVGQIS 334
            :....|...|.|||:|.|.|:..::. .::.|.|  ..:|.|...:..|.|||.|.|.|.|||..
Human   247 SLILECVASGIPPPRVTWAKDGSSVTGYNKTRFL--LSNLLIDTTSEEDSGTYRCMADNGVGQPG 309

  Fly   335 ARASLI---VHAPPNFTKRPSNKKVGLNGVVQLPCMASGNPPPSVFWTKEGVSTLMFPNSSHGRQ 396
            |...|.   |..||..|...|...:......:|.|...|||||||.|.:..|..:........|:
Human   310 AAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRR 374

  Fly   397 HVAADGTLQITDVRQEDEGYYVCSAFSVVDSSTVRVFLQVSSLDERP------------------ 443
                  .|::..:..||||.|.|.|.:.|.|:...|.|:.|    ||
Human   375 ------ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTS----RPSPPGITPRLWQDAELATG 429

  Fly   444 -PPI----------------------IQIGPANQTLP----KGSVATLPC-----RATGNPSPRI 476
             ||:                      ..:|||:...|    :|:.|..|.     |.:...|..:
Human   430 TPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYEL 494

  Fly   477 KW--FHDG------------HAVQAGNRYS--IIQGSSLRVDDLQLS--DSGT--------YTCT 515
            .|  .|:|            |..|..|...  .|.|.......|.|:  |.|:        |.|
Human   495 VWRPRHEGSGRAPILYYVVKHRKQVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNC- 558

  Fly   516 ASGERGETSWAATLTVEKP-----------------------GSTSLHRAADPSTYPAPPGTPKV 557
             :|| |:|:.....|..:|                       .|...|....|   |..|..|.:
Human   559 -AGE-GQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSP---PEAPDRPTI 618

  Fly   558 LNVSRTSISLRWAKSQEKPGAVG--PIIGYTVEYFSPDLQTGWIVAAQRVGDTQ--VTISGLTPG 618
            ...|.||:.:.|.     |...|  ||..:.|||........||:|...:..::  |.|:||..|
Human   619 STASETSVYVTWI-----PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKG 678

  Fly   619 TSYVFLVRAENTQGISVPSGLSNTIKTIEADFDAASANDLSAARTLLTGKSVELIDASAINASAV 683
            |||.|.|||.|..|.|.||..|...        ..|..........:.|..:...|  |:|.:.:
Human   679 TSYKFRVRALNMLGESEPSAPSRPY--------VVSGYSGRVYERPVAGPYITFTD--AVNETTI 733

  Fly   684 RLEWM-LHVSADEKYVEGLRIHYKDASVPSAQYHSITVMDASAESFVVGNLKKYTKYEFFLTPFF 747
            .|:|| :..|.:...:.|..|:|:.....:...:...:::.......:.:|:..|.|:..:..|.
Human   734 MLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFN 798

  Fly   748 ETIEGQPSNSKTALTYEDVPSAPPDNIQIGMYNQTAGWVRWTPPPS 793
            |..|.:.||.....|.....|..|..:               |||:
Human   799 EGGESEFSNVMICETKARKSSGQPGRL---------------PPPT 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo1	NP_476899.1	Ig	56..151	CDD:299845	22/96 (23%)
		I-set	56..150	CDD:254352	22/95 (23%)
		I-set	157..251	CDD:254352	30/98 (31%)
		Ig2_Robo	159..251	CDD:143201	29/96 (30%)
		I-set	255..341	CDD:254352	27/89 (30%)
		Ig3_Robo	272..341	CDD:143202	24/72 (33%)
		IG_like	351..436	CDD:214653	25/84 (30%)
		Ig	362..444	CDD:299845	27/100 (27%)
		I-set	445..531	CDD:254352	28/142 (20%)
		IGc2	459..521	CDD:197706	21/92 (23%)
		FN3	549..637	CDD:238020	32/91 (35%)
		FN3	673..762	CDD:238020	18/89 (20%)
		fn3	770..855	CDD:278470	4/24 (17%)
BOC	XP_016862930.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910