DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment robo1 and htra1

DIOPT Version :9

Sequence 1:	NP_476899.1	Gene:	robo1 / 37603	FlyBaseID:	FBgn0005631	Length:	1395	Species:	Drosophila melanogaster
Sequence 2:	NP_001072730.2	Gene:	htra1 / 780187	XenbaseID:	XB-GENE-487699	Length:	460	Species:	Xenopus tropicalis

Alignment Length:	256	Identity:	51/256 - (19%)
Similarity:	83/256 - (32%)	Gaps:	74/256 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   537 TSLHR----AADPSTYPAPPGTPKVLNV-SRTSISLRWAKSQEKPGAVGPIIGYTVEYFSPDLQT 596
            |:.||    .:|.|||.|     ::::| .:..|:|...|::.|...:  ::|.     |.||:.
Frog   202 TNKHRLKVERSDGSTYDA-----QIIDVDEKADIALIKIKAKGKLPVL--LLGR-----SEDLRP 254

  Fly   597 GWIVAAQRVGDTQVTISGLTPGTSYVFLVRAENTQGISVPSGLSNTIKTIEADFDAASANDLSAA 661
            |..|.|                              |..|..|.||:.|...........:|.
Frog   255 GEFVVA------------------------------IGSPFSLQNTVTTGIVSTAQRGGKELG-- 287

  Fly   662 RTLLTGKSVELIDASAI------NASAVRLEWMLHVSADEKYVEGLRIHYKDASVPSAQYHSITV 720
               |....::.|...||      ....|.|:..:......|...|:..     ::||.:......
Frog   288 ---LRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISF-----AIPSDKIRKFLA 344

  Fly   721 MDASAESFVVGNLKKYTKY---------EFFLTPFFETIEGQPSNSKTALTYEDVPSAPPD 772
            ...:.:|...|..||  ||         :..|....|.::..|.|:..|...|.:|..|.:
Frog   345 ESHNRQSTGQGTKKK--KYLGIRMMSLSQGKLKELKEQVKDFPENTSGAYIVEVIPDTPAE 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo1	NP_476899.1	Ig	56..151	CDD:299845
		I-set	56..150	CDD:254352
		I-set	157..251	CDD:254352
		Ig2_Robo	159..251	CDD:143201
		I-set	255..341	CDD:254352
		Ig3_Robo	272..341	CDD:143202
		IG_like	351..436	CDD:214653
		Ig	362..444	CDD:299845
		I-set	445..531	CDD:254352
		IGc2	459..521	CDD:197706
		FN3	549..637	CDD:238020	14/88 (16%)
		FN3	673..762	CDD:238020	20/103 (19%)
		fn3	770..855	CDD:278470	1/3 (33%)
htra1	NP_001072730.2	IGFBP	26..80	CDD:365955
		KAZAL	89..>115	CDD:197624
		degP_htrA_DO	151..>459	CDD:273938	51/256 (20%)
		Serine protease	183..343		37/192 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910