DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment robo1 and Ptk7

DIOPT Version :9

Sequence 1:	NP_476899.1	Gene:	robo1 / 37603	FlyBaseID:	FBgn0005631	Length:	1395	Species:	Drosophila melanogaster
Sequence 2:	XP_006524986.1	Gene:	Ptk7 / 71461	MGIID:	1918711	Length:	1088	Species:	Mus musculus

Alignment Length:	837	Identity:	192/837 - (22%)
Similarity:	321/837 - (38%)	Gaps:	190/837 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RIIEHPTDLVVKKNEPATLNCKVEGKPEPTIEW-FKDGEPVSTNEKKSH---RVQFKDGALFFYR 117
            |::..|.|:||.:||.|..:|:...:|.|:::| |:|..|::...:..|   .|.|.:|:|...:
Mouse   244 RVVLAPQDVVVARNEEAMFHCQFSAQPPPSLQWVFEDETPITNRSRPPHLRRAVVFANGSLLLTQ 308

  Fly   118 TMQGKKEQDGGEYWCVAKNRVGQAVSRHASLQIAVLRDDFRVEPKDTRV-AKGETALLECGPPKG 181
            .    :.::.|.|.|:.:.:.|..:...|:|.:|.:.|....||   || ..|:...:.|..|:|
Mouse   309 V----RPRNAGVYRCIGQGQRGPPIVLEATLHLAEIEDMLPFEP---RVFIAGDEERVTCPAPQG 366

  Fly   182 IPEPTLIWIKDGVPLDDLKAMSFGASSRVRIVDGGNLLISNVEPIDEGNYKCIAQNLVGTRESSY 246
            :|.|::.|...||||.        |..||. ..|..|:...:...|.|.|.|.|.||.|.|...
Mouse   367 LPTPSVWWEHAGVPLP--------AHGRVH-QKGLELVFVTIAESDTGVYTCHASNLAGQRRQD- 421

  Fly   247 AKLIVQVKPYFMKEPKDQVMLYGQTATFHCSVGGDPPPKVLWKK------EEGNIPVSRARILHD 305
            ..:.|...|.::::|:|..:..|:....||.....|.|.|:|.:      |:....||:
Mouse   422 VNITVATVPTWLRKPQDSQLEEGKPGYLHCLTQATPKPTVIWYRNQMLISEDSRFEVSK------ 480

  Fly   306 EKSLEISNITPTDEGTYVCEAHNNVGQISARASLIVHAPPNFTKRPSNKK-VGLNGVVQLPCMAS 369
            ..:|.|:::...|...|.|.:....|.|.|:|.:.|.....||..|..:: :..:....:||.|:
Mouse   481 NGTLRINSVEVYDGTLYRCVSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSAT 545

  Fly   370 GNPPPSVFWTKEGVSTL---MFPNSSHGRQHVAADGTLQITDVRQEDEGYYVCSAFSVVDSS--- 428
            |...|:|.|.:...|:|   :..|:          |||....|.::|.|.|.|.|.:.....
Mouse   546 GREKPTVKWVRADGSSLPEWVTDNA----------GTLHFARVTRDDAGNYTCIASNEPQGQIRA 600

  Fly   429 ----TVRVFLQVSSLDERPPPIIQIGPANQTLPKGSVATLPCRATGNPSPRIKWFHDGHAV---Q 486
                ||.||:           ..::.|...|:.:|..|.|.|.|.|:|.|.|:|......:   :
Mouse   601 HVQLTVAVFI-----------TFKVEPERTTVYQGHTALLRCEAQGDPKPLIQWKGKDRILDPTK 654

  Fly   487 AGNRYSIIQGSSLRVDDLQLSDSGTYTCTASGERG-ETSWAATLTVEKPGSTSLHRAADPSTYPA 550
            .|.|..|.|..||.:.|:...|||:|||.|..... ..:.|..|.|:||       ..:.|..|.
Mouse   655 LGPRMHIFQNGSLVIHDVAPEDSGSYTCIAGNSCNIRHTEAPLLVVDKP-------VMEDSEGPG 712

  Fly   551 PPGTPKVLNVSRTSISLRWA-------------------KSQEKPGAVGP----IIGYTVEYFSP 592
            .|...|::.....|:....|                   :.|::|....|    :.|..::...|
Mouse   713 SPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQP 777

  Fly   593 DLQTGWIVAAQRVGD--------------TQVTISGLTPGTSY-------VFLVRAENTQGISVP 636
            ..:....||...:|.              .....:.|.|.|:.       |||.:|:     .|.
Mouse   778 SAEIQEEVALTSLGSGPPATNKRHSAGDRMHFPRASLQPITTLGKSEFGEVFLAKAQ-----GVE 837

  Fly   637 SGLSNTIKTIEADFDAASANDLSAARTLLTGKSVELIDASAINASAVRLEWMLHVSADEKYVEGL 701
            .|.:.|:..::      |.......:.|...:.||:. ....:|:.|||..:.. .|:..|   :
Mouse   838 EGATETLVLVK------SLQSRDEQQQLDFRREVEMF-GKLNHANVVRLLGLCR-EAEPHY---M 891

  Fly   702 RIHYKDASVPSAQYHSITVMDASAESFVVGNLKKYTKYEFFLTPFFETIEGQPSNSKTALTYEDV 766
            .:.|.|                      :|:||::.:..   ....|.::.||.::|..:
Mouse   892 VLEYVD----------------------LGDLKQFLRIS---KNKDEKLKSQPLSTKQKV----- 926

  Fly   767 PSAPPDNIQIGMYNQTAGWVRWTPPPSQHHNGNLYGYK------IEVSAGNTMKVLA 817
              |....:.:||               :|.:.|.:.:|      ..:||...:||.|
Mouse   927 --ALCSQVALGM---------------EHLSNNRFVHKDLAARNCLISAQRQVKVSA 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo1	NP_476899.1	Ig	56..151	CDD:299845	26/97 (27%)
		I-set	56..150	CDD:254352	26/96 (27%)
		I-set	157..251	CDD:254352	29/94 (31%)
		Ig2_Robo	159..251	CDD:143201	29/92 (32%)
		I-set	255..341	CDD:254352	22/91 (24%)
		Ig3_Robo	272..341	CDD:143202	18/74 (24%)
		IG_like	351..436	CDD:214653	24/95 (25%)
		Ig	362..444	CDD:299845	23/91 (25%)
		I-set	445..531	CDD:254352	28/89 (31%)
		IGc2	459..521	CDD:197706	24/64 (38%)
		FN3	549..637	CDD:238020	21/131 (16%)
		FN3	673..762	CDD:238020	15/88 (17%)
		fn3	770..855	CDD:278470	10/54 (19%)
Ptk7	XP_006524986.1	IGc2	63..125	CDD:197706
		Ig2_PTK7	164..240	CDD:143237
		Ig_3	245..320	CDD:372822	21/78 (27%)
		IGc2	354..416	CDD:197706	23/70 (33%)
		Ig	430..516	CDD:386229	22/91 (24%)
		Ig	521..606	CDD:386229	22/94 (23%)
		Ig	627..687	CDD:319273	23/59 (39%)
		PTK_CCK4	808..1081	CDD:133178	40/222 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910