DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo1 and ROBO2

DIOPT Version :10

Sequence 1:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster
Sequence 2:XP_011532283.1 Gene:ROBO2 / 6092 HGNCID:10250 Length:1597 Species:Homo sapiens


Alignment Length:1472 Identity:448/1472 - (30%)
Similarity:660/1472 - (44%) Gaps:312/1472 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 NNPSRSRSSRM-WLLPAWLLLVLVASNGLPAVRGQYQSPRIIEHPTDLVVKKNEPATLNCKVEGK 82
            :.|:.|:.:|. |....|        .|...:|.:...|||:|||:|::|.|.||.|||||.||:
Human    24 SGPTLSKLTRTPWKGKPW--------KGGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGR 80

  Fly    83 PEPTIEWFKDGEPVST--NEKKSHRVQFKDGALFFYRTMQGKKEQ-DGGEYWCVAKNRVGQAVSR 144
            |.|||||:||||.|.|  ::.:|||:....|:|||.|.:.|::.: |.|.|.|||:|.:|:||||
Human    81 PTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSR 145

  Fly   145 HASLQIAVLRDDFRVEPKDTRVAKGETALLECGPPKGIPEPTLIWIKDGVPLDDLKAMSFGASSR 209
            :|||::|:||||||..|.|..||.||.|:|||.||:|.||||:.|.||.|.:||       ...|
Human   146 NASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDD-------KEER 203

  Fly   210 VRIVDGGNLLISNVEPIDEGNYKCIAQNLVGTRESSYAKLIVQVKPYFMKEPKDQVMLYGQTATF 274
            :.| .||.|:|||....|.|.|.|:..|:||.|:|..|:|.|..:|.|::.|.:||:|..:...|
Human   204 ISI-RGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEF 267

  Fly   275 HCSVGGDPPPKVLWKKEEGNIPVSRARILHDEKSLEISNITPTDEGTYVCEAHNNVGQISARASL 339
            .|.|.|||.|.|.|||::.::|..|..| .|:.:|.|.....||||||:|.|.|.||::.|.|:|
Human   268 RCQVQGDPQPTVRWKKDDADLPRGRYDI-KDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATL 331

  Fly   340 IVH----APPNFTKRPSNKKVGLNGVVQLPCMASGNPPPSVFWTKEGVSTLMFPN---SSHGRQH 397
            .|.    |||.|..||.::.|.....|..||...|||.|:|||.|||...|:|||   ..:.|..
Human   332 TVRARPVAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCS 396

  Fly   398 VAADGTLQITDVRQEDEGYYVCSAFSVVDSSTVRVFLQVSS-LDERPPPIIQIGPANQTLPKGSV 461
            |:..|.|.||::::.|.|||:|.|.:|..|...:..|:|:. |.:||||||..|||||||.....
Human   397 VSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGT 461

  Fly   462 ATLPCRATGNPSPRIKWFHDGHAVQAGN-RYSIIQGSSLRVDDLQLSDSGTYTCTASGERGETSW 525
            |.|.|:|||:|.|.|.|..:|......: |.:|.:..:|::.:|::||:|||||.|:...|||||
Human   462 ALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSW 526

  Fly   526 AATLTVEKPGSTSLHRAADPSTYPAPPGTPKVLNVSRTSISLRWAKSQEKPGAVG--PIIGYTVE 588
            :|.|.|.:.|:| :.:..|.|..|.||..|:|.:|::.|::|.|     :||..|  |...|.:|
Human   527 SAVLDVTESGAT-ISKNYDLSDLPGPPSKPQVTDVTKNSVTLSW-----QPGTPGTLPASAYIIE 585

  Fly   589 YFSPDLQTGWIVAAQRVGDTQVTISGLTPGTSYVFLVRAENTQGISVPSGLSNTIKTIEADFDAA 653
            .||..:...|...|..|..|..|:.||.|.|.|:|:|||.|.||:|.||.:|:.::|.:.. ..|
Human   586 AFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDIS-PPA 649

  Fly   654 SANDLSAARTLLTGKSVELIDASAINASAVRLEWMLHVSADEKYVEGLRIHYKDAS--VPSAQYH 716
            ...|....:..|....|.|.:...:..:.|::.|.  |....::::|.|:.|:..|  ..::.:.
Human   650 QGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWT--VDRQPQFIQGYRVMYRQTSGLQATSSWQ 712

  Fly   717 SITVMDASAESFVVGNLKKYTKYEFFLTPFFETIEGQPSNSKTALTYEDVPSAPPDNI---QIGM 778
            ::.....:..|.|:.||||...||..:.|:|...:|..|.|||..|.|:.|||||.::   .:|.
Human   713 NLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGS 777

  Fly   779 YNQTAGWVRWTPPPSQHHNGNLYGYKIEVSAGNTMKVLANMTLNATTTSVLLNNLTTGAVYSVRL 843
            ||.|:..|.|.|||..|.||.:..||| ...||..:...|.|::|...||::..|..|..|.|.:
Human   778 YNSTSISVSWDPPPPDHQNGIIQEYKI-WCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEV 841

  Fly   844 NSFTKAGDGPYSKPISLFMDPTHHVHPPRAHPSGTHDGRHEGQDLTYHNNGNIPPGDINPTTHKK 908
            .:.|.||.|..|:|..:.:                  ||.....:|.:||          :..::
Human   842 AASTSAGVGVKSEPQPIII------------------GRRNEVVITENNN----------SITEQ 878

  Fly   909 TTDYLSGPWLMVLVCIVLLVLVISAAISMVYFKRK-------HQMTKELGHLSVVSDNEITA-LN 965
            .||.:..|..:..:.....|:::..:| .:|::||       :.:|.:.|...::|:..... ||
Human   879 ITDVVKQPAFIAGIGGACWVILMGFSI-WLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLN 942

  Fly   966 INSKESLWIDHHRGWRTADTDKDSGLSESKLLSHVNSSQSNYNN--------------------- 1009
            .......|:            .||..:.|..:::.||..:...|                     
Human   943 AGDPSYPWL------------ADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQGDKTATML 995

  Fly  1010 SDGGTDYAEVDTRNLTTFYNCRKSPDNPTPYATTMIIGTSSSETCTKTTSISADKDSGTHSPYSD 1074
            |||.. |:.:|....|: ||........||||||.|:                      ||....
Human   996 SDGAI-YSSIDFTTKTS-YNSSSQITQATPYATTQIL----------------------HSNSIH 1036

  Fly  1075 AFAGQVPAVPVVKSNYLQYPVEPINWSEFLPPP----------PEH---------PPPSSTYGYA 1120
            ..|..:|. |..||: :|...:.:.:...||..          |::         .|.:.:..::
Human  1037 ELAVDLPD-PQWKSS-IQQKTDLMGFGYSLPDQNKGNNALLYIPDYRLAEGLSNRMPHNQSQDFS 1099

  Fly  1121 QGSPESS--RKSSKSAGSGISTNQSILNASIHSSSSGGFSAWGVSP---------------QYAV 1168
            ..|..:|  |..|.|.|.| ...:...|:|....::|  |.|...|               .|||
Human  1100 TTSSHNSSERSGSLSGGKG-GKKKKNKNSSKPQKNNG--STWANVPLPPPPVQPLPGTELEHYAV 1161

  Fly  1169 A-----------CPP---------------------------ENVYSNPLSAVAGGTQNRYQITP 1195
            .           |||                           ..|.|:|  |::.|.|:...:||
Human  1162 EQQENGYDSDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASSP--AISFGQQSTATLTP 1224

  Fly  1196 ---------------------------------TNQHPPQLPAYFATTGPGGAVPPNHLPFATQR 1227
                                             :|..|||.|           |||  |.:.:..
Human  1225 SPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPP-----------VPP--LGYVSGA 1276

  Fly  1228 HAASEYQAGLNAARCAQSRACNSCDALATPSPMQPPPPVP--------------VPEGWYQPVHP 1278
             ..|:.:..:     |...|.:..:||..|.|::.....|              :..||      
Human  1277 -LISDLETDV-----ADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGSMVNGW------ 1329

  Fly  1279 NSHPMHPTSSNHQIYQCSSECSDHSRSSQSHKRQLQLEEHGS 1320
                              ...||..|:..||:..:.....||
Human  1330 ------------------GSASDEDRNFSSHRSSVGSSSDGS 1353

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo1NP_476899.1 Ig 56..151 CDD:472250 54/97 (56%)
Ig strand B 73..77 CDD:409353 2/3 (67%)
Ig strand C 86..90 CDD:409353 3/3 (100%)
Ig strand E 111..115 CDD:409353 2/3 (67%)
Ig strand F 129..134 CDD:409353 2/4 (50%)
Ig strand G 143..146 CDD:409353 2/2 (100%)
IgI_2_Robo 158..251 CDD:409389 43/92 (47%)
Ig strand A 158..161 CDD:409389 1/2 (50%)
Ig strand A' 163..167 CDD:409389 1/3 (33%)
Ig strand B 171..178 CDD:409389 4/6 (67%)
Ig strand C 186..191 CDD:409389 2/4 (50%)
Ig strand C' 193..196 CDD:409389 1/2 (50%)
Ig strand D 209..213 CDD:409389 1/3 (33%)
Ig strand E 216..222 CDD:409389 3/5 (60%)
Ig strand F 229..237 CDD:409389 3/7 (43%)
Ig strand G 240..251 CDD:409389 5/10 (50%)
IgI_3_Robo 258..341 CDD:409390 35/82 (43%)
Ig strand A 258..261 CDD:409390 0/2 (0%)
Ig strand A' 263..267 CDD:409390 2/3 (67%)
Ig strand B 270..279 CDD:409390 2/8 (25%)
Ig strand C 285..290 CDD:409390 2/4 (50%)
Ig strand C' 293..296 CDD:409390 0/2 (0%)
Ig strand D 299..304 CDD:409390 2/4 (50%)
Ig strand E 305..313 CDD:409390 3/7 (43%)
Ig strand F 320..328 CDD:409390 5/7 (71%)
Ig strand G 331..341 CDD:409390 4/9 (44%)
Ig 346..437 CDD:472250 36/93 (39%)
Ig strand B 362..366 CDD:409353 1/3 (33%)
Ig strand C 375..379 CDD:409353 2/3 (67%)
Ig strand E 402..406 CDD:409353 2/3 (67%)
Ig strand F 416..421 CDD:409353 3/4 (75%)
Ig strand G 429..432 CDD:409353 0/2 (0%)
Ig 446..531 CDD:472250 39/85 (46%)
Ig strand B 462..466 CDD:409544 2/3 (67%)
Ig strand C 475..479 CDD:409544 1/3 (33%)
Ig strand E 497..501 CDD:409544 1/3 (33%)
FN3 507..>916 CDD:442628 132/415 (32%)
Ig strand F 511..516 CDD:409544 4/4 (100%)
Ig strand G 524..527 CDD:409544 2/2 (100%)
FN3 549..637 CDD:238020 35/89 (39%)
fn3 770..855 CDD:394996 32/87 (37%)
ROBO2XP_011532283.1 IgC_1_Robo 54..152 CDD:409490 54/97 (56%)
Ig strand A 54..58 CDD:409490 3/3 (100%)
Ig strand A' 61..66 CDD:409490 1/4 (25%)
Ig strand B 70..78 CDD:409490 6/7 (86%)
Ig strand C 84..89 CDD:409490 4/4 (100%)
Ig strand C' 92..94 CDD:409490 1/1 (100%)
Ig strand D 105..108 CDD:409490 1/2 (50%)
Ig strand E 111..117 CDD:409490 4/5 (80%)
Ig strand F 129..137 CDD:409490 5/7 (71%)
Ig strand G 140..152 CDD:409490 8/11 (73%)
Ig 159..244 CDD:472250 43/92 (47%)
Ig strand B 173..177 CDD:409353 2/3 (67%)
Ig strand C 187..191 CDD:409353 1/3 (33%)
Ig strand E 209..213 CDD:409353 2/3 (67%)
Ig strand F 223..228 CDD:409353 2/4 (50%)
Ig strand G 237..240 CDD:409353 1/2 (50%)
Ig 251..333 CDD:472250 35/82 (43%)
Ig strand B 265..269 CDD:409353 1/3 (33%)
Ig strand C 278..282 CDD:409353 1/3 (33%)
Ig strand E 299..303 CDD:409353 1/3 (33%)
Ig strand F 313..318 CDD:409353 3/4 (75%)
Ig strand G 326..329 CDD:409353 1/2 (50%)
IgI_4_Robo 342..439 CDD:409391 37/96 (39%)
Ig strand A 342..346 CDD:409391 1/3 (33%)
Ig strand A' 348..352 CDD:409391 0/3 (0%)
Ig strand B 358..366 CDD:409391 3/7 (43%)
Ig strand C 369..376 CDD:409391 4/6 (67%)
Ig strand C' 378..381 CDD:409391 1/2 (50%)
Ig strand D 394..399 CDD:409391 2/4 (50%)
Ig strand E 401..408 CDD:409391 4/6 (67%)
Ig strand F 414..423 CDD:409391 5/8 (63%)
Ig strand G 425..436 CDD:409391 2/10 (20%)
IgI_5_Robo 446..532 CDD:409544 39/85 (46%)
Ig strand A 446..449 CDD:409544 2/2 (100%)
Ig strand A' 453..456 CDD:409544 2/2 (100%)
Ig strand B 462..469 CDD:409544 3/6 (50%)
Ig strand C 475..480 CDD:409544 2/4 (50%)
Ig strand C' 482..484 CDD:409544 1/1 (100%)
Ig strand D 491..495 CDD:409544 1/3 (33%)
Ig strand E 498..503 CDD:409544 1/4 (25%)
FN3 <510..882 CDD:442628 129/409 (32%)
Ig strand F 511..519 CDD:409544 6/7 (86%)
Ig strand G 522..532 CDD:409544 7/9 (78%)
FN3 549..642 CDD:238020 38/97 (39%)

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