DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment robo1 and robo2

DIOPT Version :9

Sequence 1:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster
Sequence 2:XP_021337127.1 Gene:robo2 / 60309 ZFINID:ZDB-GENE-001019-1 Length:1595 Species:Danio rerio


Alignment Length:1655 Identity:477/1655 - (28%)
Similarity:710/1655 - (42%) Gaps:397/1655 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 NPSRSRSSRMWLLPAWLLLV----LVASNGLPA------VRGQYQSPRIIEHPTDLVVKKNEPAT 74
            :|.|:|.:.:...|..||::    ::.|:.:.|      :|.:...|||:|||:||:|.|.||||
Zfish     4 SPERARCAVVLAGPPLLLIICVLWILCSDSVDAQGQGSRLRQEDSPPRIVEHPSDLIVSKGEPAT 68

  Fly    75 LNCKVEGKPEPTIEWFKDGEPVST--NEKKSHRVQFKDGALFFYRTMQGKKEQ-DGGEYWCVAKN 136
            ||||.||:|.||:||:||||.|.|  ::.:|||:....|:|||.|.:.|::.: |.|.|.|||:|
Zfish    69 LNCKAEGRPTPTVEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGAYVCVARN 133

  Fly   137 RVGQAVSRHASLQIAVLRDDFRVEPKDTRVAKGETALLECGPPKGIPEPTLIWIKDGVPLDDLKA 201
            .:|:||||:|||::|:||||||..|.|..||.||.|:|||.||:|.||||:.|.||.|.:|:   
Zfish   134 YLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECVPPRGHPEPTIYWKKDKVRIDE--- 195

  Fly   202 MSFGASSRVRIVDGGNLLISNVEPIDEGNYKCIAQNLVGTRESSYAKLIVQVKPYFMKEPKDQVM 266
                ...|::| .||.|:|||....|.|.|.|:..|:||.|:|..|::.|..:|.|::.|.:||:
Zfish   196 ----KDDRIKI-RGGKLMISNTRKSDAGMYICVGTNMVGERDSETAQVTVFERPTFLRRPINQVV 255

  Fly   267 LYGQTATFHCSVGGDPPPKVLWKKEEGNIPVSR--ARILHDEKSLEISNITPTDEGTYVCEAHNN 329
            |..:...|.|.|.|||.|.:.|||::..||..|  .:...|:.:|.|...|.:||||:.|.|.|.
Zfish   256 LEEEAVEFRCQVQGDPQPSIRWKKDDVEIPRGRYDMKFDKDDFTLRIKKATASDEGTFTCVAENR 320

  Fly   330 VGQISARASLIVH----APPNFTKRPSNKKVGLNGVVQLPCMASGNPPPSVFWTKEGVSTLMFPN 390
            ||::.|.|:|.|.    |.|.|..||.::.|........||...|||.|:|||.|||...|:|||
Zfish   321 VGKMEASATLTVRARPVAAPQFVIRPRDQIVAQGRTASFPCETKGNPQPAVFWQKEGSQNLLFPN 385

  Fly   391 ---SSHGRQHVAADGTLQITDVRQEDEGYYVCSAFSVVDSSTVRVFLQVSS-LDERPPPIIQIGP 451
               ..:.|..|:..|.|.||.|::.|.|||:|.|.:|..|...:..|:|:. |.:||||||:.||
Zfish   386 QPQQPNSRFSVSPSGDLTITTVQRADAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIIRQGP 450

  Fly   452 ANQTLPKGSVATLPCRATGNPSPRIKWFHDGHAVQAGN-RYSIIQGSSLRVDDLQLSDSGTYTCT 515
            |||||...|||.|.|.|:|.|.|.|.|..||.::...: |.|:....||::..|:|||||.|||.
Zfish   451 ANQTLGVDSVALLRCHASGEPVPTISWLKDGVSLLGKDPRMSLQDLGSLQIKGLRLSDSGIYTCV 515

  Fly   516 ASGERGETSWAATLTVEKPGSTSLHRAADPSTYPAPPGTPKVLNVSRTSISLRWAKSQEKPGAVG 580
            |:...|||||:|.|.|::.||..:.:..|.:..|.||..|:|.:|::.|:||.|     :||..|
Zfish   516 AASSSGETSWSAFLEVKEAGSLVVVKDRDENELPGPPSKPQVTDVTKNSVSLSW-----QPGLPG 575

  Fly   581 --PIIGYTVEYFSPDLQTGWIVAAQRVGDTQVTISGLTPGTSYVFLVRAENTQGISVPSGLSNTI 643
              .|..|.:|.||..:...|...|.....||.||.||.|.|.|:|:|||.|.||:|.||.:|..:
Zfish   576 ASAISTYVIEAFSQSVSNSWQTVADHAKTTQYTIKGLRPNTIYLFMVRAVNVQGLSDPSPMSEPV 640

  Fly   644 KTIEADFDAASANDLSAARTLLTGK-SVELIDASAINASAVRLEWMLHVSADEKYVEGLRIHYKD 707
            :|.:....|...:.....:.|  |: .|.|.:...::.:.:::.|.  |....::::|.|:.|:.
Zfish   641 RTQDISPPAQGVDHRHVQKEL--GEVIVRLHNPVVLSPTTIQVTWT--VDRQSQFIQGYRVLYRQ 701

  Fly   708 ---ASVPSAQYHSITVMDASAESFVVGNLKKYTKYEFFLTPFFETIEGQPSNSKTALTYEDVPSA 769
               .|.|.| :.:..|...|..|.|:..|||...||..:.|:|...:|..|.|:||.|.|:.|||
Zfish   702 MSGLSSPGA-WQTQDVKVPSERSMVLSALKKGIVYEIKVRPYFNEFQGMDSESRTARTTEEAPSA 765

  Fly   770 PPDNI---QIGMYNQTAGWVRWTPPPSQHHNGNLYGYKIEVSAGNTMKVLANMTLNATTTSVLLN 831
            ||..:   .:|..|.|:..:.|.|||::|.||.:..||| ...||..:...|.|::|...||::.
Zfish   766 PPQQVTVLTVGNQNSTSISISWDPPPAEHQNGIIQEYKI-WCLGNETRFHVNKTVDAAIRSVVVG 829

  Fly   832 NLTTGAVYSVRLNSFTKAGDGPYSKPISLFMDPTHHVHPPRAHPSGTHDGRHEGQDLTYHNNGNI 896
            .|..|..|.|.:.:.|.||.|..|:|.::.:                  |: :.:|:....|.:|
Zfish   830 GLQAGVQYRVEVAASTSAGVGVKSEPQTIII------------------GK-DFRDVMISRNNSI 875

  Fly   897 PPGDINPTTHKKTTDYLSGPWLMVLVCIVLLVLVISAAISMVYFKRKHQMTKELGHLSVVSDNEI 961
            .         ::.||.:..|..:..:.....|:::..:| .:|::||.:  |.|.:.:|.|....
Zfish   876 T---------EQITDVVKQPAFIAGIGGACWVILMGFSI-WLYWRRKKR--KGLSNYAVQSFTFT 928

  Fly   962 TALNINSKESLWIDHHRGWRTADTDKDSGL-SESKLLSHVNSSQSNY-------------NNSDG 1012
            .|:....                  .|.|| |.......:|:|.|.|             |:..|
Zfish   929 PAVTFQR------------------VDGGLMSNGSRPGLLNASDSGYPWLADSWPPSLPVNSGSG 975

  Fly  1013 GTD---------------------------YAEVDTRNLTTFYNCRKSP-DNPTPYATTMIIGTS 1049
            |.:                           |:.:|......|.:  .|| ...||||||.|:.::
Zfish   976 GPNDLSFGRGDVMPSAQADKTGTMLSDGAIYSSIDFTTKGGFGS--PSPASQATPYATTQILHSN 1038

  Fly  1050 S--------------------------------SETCTKTTSISAD----------------KDS 1066
            |                                ..:|..|.....|                :|.
Zfish  1039 SIHELAVDLPEAQWKTSLQAKQEMASLGYSLPDKNSCNNTLLFIPDYRLADGLSNRMPHNQSQDF 1103

  Fly  1067 GTHSPYSDA------FAGQVPAVPVVKSNYLQYPVEPINWSEF-LPPPPEHPPPSSTYG-YAQGS 1123
            .|.|.::.:      ..|:.......|:|.....:...||:.. |||||.||.|.:... ||...
Zfish  1104 STTSSHNSSDRSNSLSGGKGGKKKKTKANVKPTKMNGSNWANVPLPPPPIHPLPGTEMDHYASEH 1168

  Fly  1124 PESSRKSSKSAGSGISTNQSILNASIHSSSSGGFSAWGVSPQYAVACPP-ENVYSNPLSAVAGGT 1187
            .:.....|...|..:.. |:.|:..:.....        ..:..|..|| ..|.|:| :||:.|.
Zfish  1169 HDGGGYDSDGWGPPLPV-QTYLHQGLEDELE--------EEEERVPTPPIRGVASSP-AAVSFGK 1223

  Fly  1188 QNRYQITPT---------------------------------NQHPPQLPA----YFATT----- 1210
            |:...::|:                                 ..:|||.||    |.::|     
Zfish  1224 QSTATLSPSPREEMQPMLQAHLDELTRAYQLDMAKQTWHMQGGPYPPQAPAPPVGYVSSTLVSDI 1288

  Fly  1211 -----------------------------------------------GPGGAVPPNHLPFATQRH 1228
                                                           |.|.|...:...|:::|.
Zfish  1289 ETDLPDEDDDDEEDEGYEMSPPIRGTEHTPGSSMDNLDSSVTGSMVNGWGSASEDDDRNFSSRRS 1353

  Fly  1229 AASEYQAGLNAARCAQSRAC--------------------------------------------- 1248
            :|.....|.....|:.:||.                                             
Zfish  1354 SAGSSSDGSLFTHCSFARALVAAADKAGYRLDGTSLSKRDKGLPHRPRPASPFSTDGSTVGTHSL 1418

  Fly  1249 -------------------NSCDALA--TPSPMQPPP--PVPVPEGWYQPVHPNSHPMHPTSSNH 1290
                               |..||.|  .|.|.:|||  ...:|.....|     ||....:|:.
Zfish  1419 GHQRAARPTRKHKGPGTVPNRRDASADDLPPPPEPPPCQTARIPGSRNVP-----HPCDRKASSL 1478

  Fly  1291 Q------IYQCSSECSDHSRSSQSHKRQLQLEEHGSSAKQRGGHHRR---RAPVVQPCMESENEN 1346
            :      :.:..|.....:|:|....:|:| :..||.  :||...||   ..|.        :|.
Zfish  1479 ERQPMMGLEEMRSSLDRQARTSLDRHQQVQ-DRLGSI--ERGDESRRGQKNGPF--------SEE 1532

  Fly  1347 MLAEYEQRQYTSDCCNSSREGDTCSCSEGS 1376
            .|..|.:..:.|...:||  ..|.| |:||
Zfish  1533 ALLPYNKPSFPSPGGHSS--SGTAS-SKGS 1559

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo1NP_476899.1 Ig 56..151 CDD:299845 55/97 (57%)
I-set 56..150 CDD:254352 55/96 (57%)
I-set 157..251 CDD:254352 42/93 (45%)
Ig2_Robo 159..251 CDD:143201 40/91 (44%)
I-set 255..341 CDD:254352 35/87 (40%)
Ig3_Robo 272..341 CDD:143202 29/70 (41%)
IG_like 351..436 CDD:214653 34/87 (39%)
Ig 362..444 CDD:299845 35/85 (41%)
I-set 445..531 CDD:254352 44/86 (51%)
IGc2 459..521 CDD:197706 27/62 (44%)
FN3 549..637 CDD:238020 37/89 (42%)
FN3 673..762 CDD:238020 24/91 (26%)
fn3 770..855 CDD:278470 30/87 (34%)
robo2XP_021337127.1 Ig1_Robo 49..148 CDD:143317 55/98 (56%)
Ig 156..240 CDD:325142 40/91 (44%)
I-set 244..332 CDD:254352 35/87 (40%)
Ig4_Robo 354..443 CDD:143203 35/88 (40%)
IG 450..531 CDD:214652 40/80 (50%)
FN3 549..642 CDD:238020 40/97 (41%)
FN3 673..758 CDD:238020 24/87 (28%)
FN3 767..859 CDD:238020 31/92 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 81 1.000 Domainoid score I8418
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H43188
Inparanoid 1 1.050 622 1.000 Inparanoid score I848
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000772
OrthoInspector 1 1.000 - - mtm6572
orthoMCL 1 0.900 - - OOG6_101537
Panther 1 1.100 - - O PTHR12231
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3358
SonicParanoid 1 1.000 - - X493
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1211.990

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