DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment robo1 and NECTIN2

DIOPT Version :9

Sequence 1:	NP_476899.1	Gene:	robo1 / 37603	FlyBaseID:	FBgn0005631	Length:	1395	Species:	Drosophila melanogaster
Sequence 2:	NP_001036189.1	Gene:	NECTIN2 / 5819	HGNCID:	9707	Length:	538	Species:	Homo sapiens

Alignment Length:	395	Identity:	92/395 - (23%)
Similarity:	137/395 - (34%)	Gaps:	109/395 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 ALLECGPPKGIPEPTLIWIKDGVPLDDLKAMSFGASS-RVRIVD------GGNLLISNVEPIDEG 229
            |||   |.:..|.| |:|     ||..|..:..||.. ||:::.      ||.:
Human     6 ALL---PSRSPPTP-LLW-----PLLLLLLLETGAQDVRVQVLPEVRGQLGGTV----------- 50

  Fly   230 NYKCIAQNLVGTRESSYAKLIVQVKPYFMKEPKDQVMLYGQTATFHCSVGGD-PPPK-------- 285
            ...|   :|:......|..|:...:|       |....:...|.||..:|.. |.||
Human    51 ELPC---HLLPPVPGLYISLVTWQRP-------DAPANHQNVAAFHPKMGPSFPSPKPGSERLSF 105

  Fly   286 VLWKKEEGNIPVSRARILHDEKSLEISNITPTDEGTYVCE-AHNNVGQISARASLIVHAPP---- 345
            |..|:..|....:..:    :.:|.:..:|..|||.|.|| |....|.:.....|.|.|.|
Human   106 VSAKQSTGQDTEAELQ----DATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQA 166

  Fly   346 -----NFTKRPSNKKVGLNGVVQLPCMASGNPPPSVFWTKEGVSTLMFPNSSHGRQHVAADGTLQ 405
                 .|::.|:        .|.|.....|.||..:.|    :|:|.:.     .:.....|||.
Human   167 EAQKVTFSQDPT--------TVALCISKEGRPPARISW----LSSLDWE-----AKETQVSGTLA 214

  Fly   406 ITDVRQEDEGYYVCSAFSVV-----DSSTVRVFLQVSSLDE----------RPPPIIQIGPANQT 455
            .|        ..|.|.|::|     |..||...::..|.:|          |.||.:.|...:..
Human   215 GT--------VTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDN 271

  Fly   456 LPKGSV-ATLPCRATGNPSPR-IKWFHDGHAVQAGN--RYSIIQGSSLRVDDLQLSDSGTYTCTA 516
            ...|.. |||.|....||.|. ..|     :..:|.  ..::.|||.|.:..:....:.|:.||.
Human   272 WYLGRTDATLSCDVRSNPEPTGYDW-----STTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTV 331

  Fly   517 SGERG 521
            :...|
Human   332 TNAVG 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo1	NP_476899.1	Ig	56..151	CDD:299845
		I-set	56..150	CDD:254352
		I-set	157..251	CDD:254352	21/85 (25%)
		Ig2_Robo	159..251	CDD:143201	21/85 (25%)
		I-set	255..341	CDD:254352	23/95 (24%)
		Ig3_Robo	272..341	CDD:143202	21/78 (27%)
		IG_like	351..436	CDD:214653	20/89 (22%)
		Ig	362..444	CDD:299845	22/96 (23%)
		I-set	445..531	CDD:254352	20/81 (25%)
		IGc2	459..521	CDD:197706	17/65 (26%)
		FN3	549..637	CDD:238020
		FN3	673..762	CDD:238020
		fn3	770..855	CDD:278470
NECTIN2	NP_001036189.1	IG_like	40..158	CDD:214653	29/142 (20%)
		Ig	48..159	CDD:299845	28/135 (21%)
		Ig	162..257	CDD:299845	24/119 (20%)
		IG_like	278..346	CDD:214653	17/64 (27%)
		Ig_3	<280..333	CDD:290638	15/57 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..414
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..489
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000