DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo1 and cadm1a

DIOPT Version :9

Sequence 1:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster
Sequence 2:NP_001107023.2 Gene:cadm1a / 569931 ZFINID:ZDB-GENE-080505-2 Length:446 Species:Danio rerio


Alignment Length:516 Identity:120/516 - (23%)
Similarity:192/516 - (37%) Gaps:136/516 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   237 NLVGTRESSYAKLIVQV----------KPYFMKEP---KDQV-MLYGQTATFHCSVGG------- 280
            |:..|...|.|.|::.:          ..|.::..   .|.| ::.|:|||..|.|..       
Zfish     6 NMANTSNGSLATLLILITISAAIHTGAAQYPVQSQNLISDNVSVVEGETATISCRVKNNDDSVIQ 70

  Fly   281 --DPPPKVLWKKEEGNIPVSRARILH---DEKSLEISNITPTDEGTYVCEAHNNVGQISARASLI 340
              :|..:.::.|:...:..:|.::::   :|..:.:||::.:|||.|||:.:.:..| .|.|.:.
Zfish    71 LLNPNRQTIYFKDVRPLKDARFQLVNFSDNELRVSLSNVSLSDEGRYVCQLYTDPPQ-EAYADIT 134

  Fly   341 VHAPPNFTKRPSNKKVGLNG-VVQLPCMASGN-PPPSVFWTK-----EGVSTL------MFPNSS 392
            |..||......|.:.:...| ..::.|.:.|: |..::.|.|     :|.|.:      ||..:|
Zfish   135 VLIPPGNPIIESREDIVSEGNETEITCTSMGSKPAATIRWMKGDKELQGKSKVELTYDKMFTVTS 199

  Fly   393 HGRQHVAADGTLQITDVRQEDEGYYVCSAFSVVDSSTVRVFLQVSSLDERPPPIIQI------GP 451
                      .|::|..|::|....||    :||...|:.|.....|:.:..|.:||      ||
Zfish   200 ----------WLRLTVTREDDGVPVVC----IVDHPAVKDFQAQKYLEVQYKPEVQIVVDFPSGP 250

  Fly   452 ANQTLPKGSVATLPCRATGNPSP-RIKWFHDGHAVQAGNRYSIIQGSSLRVDDLQLSDSGTYTCT 515
                :.:|....|.|.|.|.|.| ::.|......|.:   :::|.||.|.:::|..|.:|||.|.
Zfish   251 ----IREGENLELTCLAKGKPEPQQVNWVRVDDDVPS---HAVITGSDLFIENLNKSYNGTYRCV 308

  Fly   516 ASGERGETSWAATLTVEKPGSTSLHRAADPSTYPAPPGTPKVLNVSRTSISLRWAKSQEKPGAVG 580
            ||...||......|.|.           |..|....|.|.....:|.|:          .|..|.
Zfish   309 ASNPLGEAYDDYILFVR-----------DALTTTPIPTTTTTTTISATT----------SPPDVI 352

  Fly   581 PIIGYTVEYFSPDLQTGWIVAAQRVGDTQVTISGLTPGTSYVFL----------VRAENTQGISV 635
            .....:.|..:.|.|.|  ...||..| ...|.|:.....:..|          .|.:.|.....
Zfish   353 QDAAPSTEAAAHDSQAG--AETQRSMD-HALIGGVVAVVVFAMLCLLIVLGRYFARHKGTYFTHE 414

  Fly   636 PSGLSNTIKTIEADFDAASANDLSAARTLLTGKSVELIDASAINASAVRLEWMLHVSADEK 696
            ..|         || |||.|                  |.:.|||...      |.::|||
Zfish   415 AKG---------AD-DAADA------------------DTAIINAEGG------HNNSDEK 441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo1NP_476899.1 Ig 56..151 CDD:299845
I-set 56..150 CDD:254352
I-set 157..251 CDD:254352 5/13 (38%)
Ig2_Robo 159..251 CDD:143201 5/13 (38%)
I-set 255..341 CDD:254352 24/101 (24%)
Ig3_Robo 272..341 CDD:143202 19/80 (24%)
IG_like 351..436 CDD:214653 22/97 (23%)
Ig 362..444 CDD:299845 21/93 (23%)
I-set 445..531 CDD:254352 29/92 (32%)
IGc2 459..521 CDD:197706 21/62 (34%)
FN3 549..637 CDD:238020 18/97 (19%)
FN3 673..762 CDD:238020 8/24 (33%)
fn3 770..855 CDD:278470
cadm1aNP_001107023.2 Ig 41..135 CDD:299845 23/94 (24%)
IG_like 46..135 CDD:214653 22/89 (25%)
Ig 156..237 CDD:299845 21/94 (22%)
Ig_3 243..311 CDD:290638 22/74 (30%)
IG_like 247..324 CDD:214653 26/83 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
00.000

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