DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo1 and sdk2b

DIOPT Version :10

Sequence 1:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster
Sequence 2:XP_009305142.1 Gene:sdk2b / 564922 ZFINID:ZDB-GENE-030131-8203 Length:2256 Species:Danio rerio


Alignment Length:1540 Identity:335/1540 - (21%)
Similarity:544/1540 - (35%) Gaps:421/1540 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 MHPENHAIARSTSTTNNPSRS-----RSSRMWLLPAW---LLLVLV----ASNGLPAVRGQYQSP 56
            |:|    ..|:.:...:||.:     .|.:..:.|.|   |||||:    |.:.:|.   .:::.
Zfish     1 MYP----ACRTNAFCISPSAALAMFGNSGKARMRPCWIVILLLVLLHLASAQDDVPP---YFKTE 58

  Fly    57 RIIEHPTDLVVKKNEPATLNCKVEGKPEPTIEWFKDGEPVSTNEKKSHRVQFKDGALFFYRTMQG 121
            .:   |:.|.:::|. ..|.|..||......:|..       |:.:..|...:      ||.:..
Zfish    59 PV---PSQLHLERNR-LVLTCMAEGSWPLEFKWIH-------NDTEITRFSLE------YRYLIP 106

  Fly   122 KKEQD-GGEYWCVAKNRVGQAVSRHASLQIAVLRDDFRVEPKDTRVAKGETALLECGPPKGIPEP 185
            ..::. .|.|.|:.:||||..:.|...:|:|.: ..|....:...|::||.|::.....:..|:|
Zfish   107 SLDRSHAGFYRCIVRNRVGALLQRRTEVQVAYM-GSFEEGERTQAVSQGEGAVIPAPRIRCFPQP 170

  Fly   186 TLIWIKDG--VPLDDLKAMSFGASSRVRI-VDGGNLLISNVEPIDEGNYKCIAQNLVG--TRESS 245
            .:.|.:||  :|          .|||:.| :|...:::|.|.| |.|.|...|.|...  .:...
Zfish   171 QVTWFRDGRKIP----------PSSRIAITLDNTLVILSTVAP-DAGRYYVQAVNDKNGENKTGQ 224

  Fly   246 YAKLIVQ--------VKPYFMKEPKDQVMLYGQT-ATFHCSVGGDPPPK--VLWKKEEGNIPVSR 299
            :..|.|:        :.|..:..|::..::.|.: .|..|.....|..|  :.|||:.   .:.|
Zfish   225 HITLSVENVGGPADPIAPTIVIPPRNTSVISGTSEVTMECVANARPLIKLSISWKKDG---VLVR 286

  Fly   300 ARILHDEKSLEISNITPTDEGTYVCEA---HNNVGQISARASLIVHAPPNFTKRPSNK-KVGLNG 360
            :.:....:.|.:.:...:|.|.|.|||   .::|..:||.|.|.|..||.|.|.|... ...:..
Zfish   287 SGLSDFNRRLTVLSPAVSDSGFYECEAVLRSSSVPAVSAGAYLHVLEPPQFVKEPEKHITAEMEK 351

  Fly   361 VVQLPCMASGNPPPSVFWTKEGV--STLMFPNSSHGRQHVAADGTLQITDVRQEDEGYYVCSAFS 423
            ||.:||.|.|.|.|.:.|.|:.|  |.:..|     |..|.:.|:||:..:..:|.|.:.|.|.:
Zfish   352 VVDIPCQARGVPQPDIVWYKDAVPISPVKTP-----RYRVLSGGSLQVNGLLPDDTGMFQCFARN 411

  Fly   424 VVDSSTVRVFLQVSSLDERPPPIIQIGPANQTLPKGSVATLPCRATGNPSPRIKWFHDGHAVQAG 488
            .........:|.|:|:    .|.|..||::.|:..|....|.|..:|.|.|.|.|......:.:|
Zfish   412 QAGEVQTNTYLAVTSI----APNITAGPSDSTVIDGMSVILHCETSGAPRPAITWQKGERVLASG 472

  Fly   489 N----RYSIIQGSSLRVDDLQLSDSGTYTCTASGERG--ETS-----WA---------------- 526
            :    |:::::..||.:....:||:|||||.||..||  |.|     ||                
Zfish   473 SVQLPRFTLLESGSLLISPSHISDAGTYTCMASNSRGIDEASADLVVWARTRITNPPQDQSVIKG 537

  Fly   527 --ATLTV--------------EKPGST---------------SLH----RAADPSTY-------- 548
              ||:|.              ||.|..               :||    .:.|..||        
Zfish   538 TKATMTCGVTHDPSVSVRFVWEKDGQVIVTQGLPRLRLDVNGTLHISQTWSGDIGTYTCRVTSVG 602

  Fly   549 --------------PAPPGTPKVL--NVSRTSISLRWAKSQEKPGAVGPIIGYTVEYFSPDLQTG 597
                          |..|..|..:  :..:.:|:|.|||..:   ...|:|.|.:|.  .:....
Zfish   603 GNDSRNAHLRVRQLPHAPENPSAVLSSTEKRAINLTWAKPFD---GNSPLIRYILEV--SENNAP 662

  Fly   598 WIVAAQRV--GDTQVTISGLTPGTSYVFLVRAENTQGISVPSGLSNTIKTIEADFDAASANDLSA 660
            |.|....:  ..|.||::||.|..||.|.:.|.|..|....|..::.:...|....|...|.:::
Zfish   663 WTVLLANIEPESTAVTVNGLIPARSYQFRLCAVNDVGKGQFSKETDRVSLPEEPPSAPPQNVIAS 727

  Fly   661 ARTLLTGKSVELIDASAINASAVRLEWMLHVSADEK-YVEGLRIHYKDASVP-SAQYHSITVMDA 723
            .||               |.| :.::|.....:.:. .:.|..|.|:...:| ..||.:|:..|.
Zfish   728 GRT---------------NQS-IMIQWQPPPESHQNGILRGYIIRYRLTGLPVDIQYKNISNPDV 776

  Fly   724 SAESFVVGNLKKYTKYEFFLTPFFETIEGQPSNSKTALTYEDVPSAPPDNIQIGMYNQTAGWVRW 788
            :  :.::.:|..:|.||..:..:.....|...:..|..|.:.||:..|.|::....|.|.....|
Zfish   777 T--NLLLEDLIIWTNYEIEVAAYNGAGLGVYCHKVTEWTLQGVPTIAPGNVKAEPVNSTTIRFTW 839

  Fly   789 TPPPSQHHNGNLYGYKIEV----SAGNTMKVLANMTLNATTTSVLLNNLTTGAVYSVRLNSFTKA 849
            |.|..|..||...|||:..    ....|..|........:.....:..|...:.|...:..||..
Zfish   840 TAPNPQFINGINQGYKLLAWEPGKEDETTVVTVRPNFQDSVHVGHIGGLKKFSEYYTSVLCFTTP 904

  Fly   850 GDGPYSKPISLFMDPTHHVHPPR-AHPSGTH----------------DGRHEGQDLTYHNNGNIP 897
            ||||.|.|..|   .||...|.. .|.|.|.                :|...|..:::.....  
Zfish   905 GDGPRSSPRRL---RTHEDTPGAVGHLSFTEILDTSLKVSWREPNEKNGVLTGYRISWEEYNR-- 964

  Fly   898 PGDINPTTHKKTTDYLSGPWLMVLVCIVLLVLVISAAISMVYFKRKHQMTKELGHLSVVSD---- 958
                   |:.:.|.||....|...|..:..:...:..::.:..|.:.|::.     |.:|.    
Zfish   965 -------TNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQLSS-----STISSGVPP 1017

  Fly   959 ------NEITALNINSKESLWIDHHRG---------WRTADTDKDSGLSESKLLSHVNSSQSNYN 1008
                  ..:...||..: ::.:....|         |:........|.:|..::.|..:::.:..
Zfish  1018 ELPGPPTNLAISNIGPR-TVTLQFKPGYDGKTSISRWQVEAQVGVIGENEDWVMVHQRANEPDAR 1081

  Fly  1009 NSDGGTDYAEVDTRNLTTFYNCRKSPDNPTPYATTMIIGTS-SSETCTKTTSISADKDSGTHSPY 1072
            :       .||...|..|||..|....|        |:||| .|:...|..::.|..|       
Zfish  1082 S-------LEVSGLNPYTFYRFRMRQVN--------IVGTSPPSQPSRKIQTLQAPPD------- 1124

  Fly  1073 SDAFAGQVPAVPVVKSNYLQYPVEPINWSEFLPPPP-EHPPPSSTYGY-----AQGSPES----- 1126
                  ..||     :..|:...|...|..::|.|. |:.....:.||     ..|:|..     
Zfish  1125 ------MAPA-----NVTLRTASETSLWLRWVPLPEWEYNGNPDSVGYRVQYSRTGAPSKALLHV 1178

  Fly  1127 ------------------------------------------SRKSSKSAGSGISTNQSILNASI 1149
                                                      :|:|..|.|   .||.|    :.
Zfish  1179 IADRLEREFTIEDLEEWTEYEVRVQAINGIGAGPWSQPVRGRTRESVPSCG---PTNVS----AF 1236

  Fly  1150 HSSSSGGFSAWGVSPQ---------YAVACPPENVYSNPLS--AVAGGTQNRYQITPTNQHPPQL 1203
            .::||.....|...|:         |.||. .|....:||.  .|.|...:..|:          
Zfish  1237 ATTSSSILVRWFEVPEPDRNGLILGYKVAY-KEKDSDSPLQFWTVEGNASHSVQL---------- 1290

  Fly  1204 PAYFATTGPGGAVPPNHLPFATQRHAASEYQAGLNAARCAQSRACNSCDALATPSPMQ------P 1262
                  ||.|             ::...|.|. |...|....|.       :|||.::      |
Zfish  1291 ------TGLG-------------KYVLYEIQV-LAFTRIGDGRP-------STPSILERTLDDVP 1328

  Fly  1263 PPPVPV--PEG--------WYQPVHPN--------SHPMHPTSSN 1289
            .|||.:  ||.        |..|..||        ::.::.|:||
Zfish  1329 GPPVVILFPEVRTTSVRLIWQPPSQPNGIILAYQITYRLNSTNSN 1373

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo1NP_476899.1 Ig 56..151 CDD:472250 21/95 (22%)
Ig strand B 73..77 CDD:409353 1/3 (33%)
Ig strand C 86..90 CDD:409353 0/3 (0%)
Ig strand E 111..115 CDD:409353 0/3 (0%)
Ig strand F 129..134 CDD:409353 2/4 (50%)
Ig strand G 143..146 CDD:409353 1/2 (50%)
IgI_2_Robo 158..251 CDD:409389 24/97 (25%)
Ig strand A 158..161 CDD:409389 0/2 (0%)
Ig strand A' 163..167 CDD:409389 0/3 (0%)
Ig strand B 171..178 CDD:409389 1/6 (17%)
Ig strand C 186..191 CDD:409389 1/4 (25%)
Ig strand C' 193..196 CDD:409389 1/4 (25%)
Ig strand D 209..213 CDD:409389 2/4 (50%)
Ig strand E 216..222 CDD:409389 0/5 (0%)
Ig strand F 229..237 CDD:409389 3/7 (43%)
Ig strand G 240..251 CDD:409389 1/12 (8%)
IgI_3_Robo 258..341 CDD:409390 22/88 (25%)
Ig strand A 258..261 CDD:409390 0/2 (0%)
Ig strand A' 263..267 CDD:409390 0/3 (0%)
Ig strand B 270..279 CDD:409390 2/9 (22%)
Ig strand C 285..290 CDD:409390 2/6 (33%)
Ig strand C' 293..296 CDD:409390 0/2 (0%)
Ig strand D 299..304 CDD:409390 1/4 (25%)
Ig strand E 305..313 CDD:409390 1/7 (14%)
Ig strand F 320..328 CDD:409390 5/10 (50%)
Ig strand G 331..341 CDD:409390 4/9 (44%)
Ig 346..437 CDD:472250 26/93 (28%)
Ig strand B 362..366 CDD:409353 1/3 (33%)
Ig strand C 375..379 CDD:409353 0/3 (0%)
Ig strand E 402..406 CDD:409353 2/3 (67%)
Ig strand F 416..421 CDD:409353 1/4 (25%)
Ig strand G 429..432 CDD:409353 0/2 (0%)
Ig 446..531 CDD:472250 33/113 (29%)
Ig strand B 462..466 CDD:409544 1/3 (33%)
Ig strand C 475..479 CDD:409544 1/3 (33%)
Ig strand E 497..501 CDD:409544 2/3 (67%)
FN3 507..>916 CDD:442628 116/515 (23%)
Ig strand F 511..516 CDD:409544 4/4 (100%)
Ig strand G 524..527 CDD:409544 3/25 (12%)
FN3 549..637 CDD:238020 26/91 (29%)
fn3 770..855 CDD:394996 23/88 (26%)
sdk2bXP_009305142.1 Ig_3 52..122 CDD:464046 16/89 (18%)
Ig 147..230 CDD:472250 24/93 (26%)
Ig strand B 157..166 CDD:409353 1/8 (13%)
Ig strand C 171..175 CDD:409353 0/3 (0%)
Ig strand E 193..197 CDD:409353 0/3 (0%)
Ig strand F 207..212 CDD:409353 1/4 (25%)
Ig strand G 220..223 CDD:409353 0/2 (0%)
Ig_3 242..313 CDD:464046 16/73 (22%)
Ig 335..424 CDD:472250 27/93 (29%)
Ig strand B 353..357 CDD:409570 1/3 (33%)
Ig strand C 366..370 CDD:409570 0/3 (0%)
Ig strand E 390..394 CDD:409570 2/3 (67%)
Ig strand F 404..409 CDD:409570 1/4 (25%)
Ig strand G 417..420 CDD:409570 0/2 (0%)
Ig_3 429..506 CDD:464046 25/76 (33%)
Ig 523..617 CDD:472250 11/93 (12%)
Ig strand B 540..544 CDD:409353 2/3 (67%)
Ig strand C 555..559 CDD:409353 0/3 (0%)
Ig strand E 579..583 CDD:409353 1/3 (33%)
Ig strand F 593..598 CDD:409353 2/4 (50%)
Ig strand G 606..609 CDD:409353 0/2 (0%)
FN3 <636..1055 CDD:442628 96/459 (21%)
fn3 1021..1110 CDD:394996 19/104 (18%)
fn3 1126..1214 CDD:394996 12/92 (13%)
FN3 1230..1318 CDD:238020 25/129 (19%)
FN3 1309..>1755 CDD:442628 17/72 (24%)
FN3 1328..1421 CDD:238020 13/46 (28%)
FN3 1427..1522 CDD:238020
FN3 1751..1848 CDD:238020
fn3 1875..1952 CDD:394996
Blue background indicates that the domain is not in the aligned region.

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