DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment robo1 and unc5cb

DIOPT Version :9

Sequence 1:	NP_476899.1	Gene:	robo1 / 37603	FlyBaseID:	FBgn0005631	Length:	1395	Species:	Drosophila melanogaster
Sequence 2:	NP_001093454.1	Gene:	unc5cb / 557316	ZFINID:	ZDB-GENE-030131-9196	Length:	948	Species:	Danio rerio

Alignment Length:	872	Identity:	173/872 - (19%)
Similarity:	278/872 - (31%)	Gaps:	271/872 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RSTSTTNNPSRSRSSRMWLLPAWLLLVLVASN---------GLPAVRGQYQS------PRIIEHP 62
            ||..|.:.........|..:..:.||.|:.|:         ||..:...:.|      |..:..|
Zfish     4 RSGETASGSGLLARMMMISVRVFTLLSLIISSAAAQDDDYLGLGELPETFPSDPPEPLPHFLMEP 68

  Fly    63 TDLVVKKNEPATLNCKVEGKPEPTI------EWFKDGEPVSTNEKKSHRVQ----------FKDG 111
            .:..:.||:|..|.||  ..|...|      ||.         .:|.|.|:          .::.
Zfish    69 EEAYIVKNKPVNLYCK--ATPATQIYFKCNSEWV---------HQKEHTVEERVDETSGLVVREA 122

  Fly   112 ALFFYRTMQGKKEQDGGE-YW--CVAKNRVGQAVSRHASLQIAVLRDDFRVEPKDTRVAKGETAL 173
            ::..  |.|..:|..|.| :|  |||.:..|...||.|.::||.||..|..||....|:..:..|
Zfish   123 SIEI--TRQQVEELFGLEDFWCQCVAWSSAGTTKSRKAHVRIAYLRKTFDQEPLGKEVSLEQEVL 185

  Fly   174 LECGPPKGIPEPTLIWIKDGVPLDDLKAMSFGASSRVRIVDGGNLLISNVEPIDEGNYKCIAQNL 238
            |:|.||:|||...:.|:|:...:|.....:|      .|....||:|......|..||.|:|:|:
Zfish   186 LQCRPPEGIPAAEVEWLKNEEIIDPADDRNF------YITIDHNLIIKQARLSDTANYTCVAKNI 244

  Fly   239 VGTRESSYAKLIVQVKPYFMKEPKDQVMLYGQTATFHCSVGGDPPPKVLWKK-EEGNIPVSRARI 302
            |..|.|:.|.:||.|.                        ||       |.. .|.::..||...
Zfish   245 VAKRRSTTATVIVYVN------------------------GG-------WSTWTEWSVCSSRCGR 278

  Fly   303 LHDEKSLEISNITPTDEGTYVCEAHNNVGQISARASLIVHAP------------------PNFTK 349
            ...:::...:|..|.:.|. :||     ||...:.:.....|                  .::.:
Zfish   279 GFQKRTRSCTNPAPLNGGA-ICE-----GQAIQKLACNPLCPVDGLWTEWSKWSTCGTECTHWRR 337

  Fly   350 RPSNKKVGLNG-------VVQLPCMASGNPPPSVFWTKEGVSTLMFPNSSHGRQHVAADGTLQIT 407
            |..:.....||       |:|......|....|..:.|....|    :.|:...|.:|..|
Zfish   338 RECSAPAPKNGGKDCEGTVLQSKNCTDGLCMQSSLYQKSSEHT----DKSNALPHPSAPST---- 394

  Fly   408 DVRQEDEGYYV--------CSAFSVVDSSTVRVFLQVSSLDERPPPIIQIGPANQTLPKGSVATL 464
                :|...||        |...||:    |.:|:...:..:....|:
Zfish   395 ----DDVALYVGIVIAVIMCLVISVI----VALFVYRKNHRDFDSDIM----------------- 434

  Fly   465 PCRATGNPSPRIKWFHDGHAVQAGNRYSIIQGSSLRVDDLQLSDSGTYTCTASGERGETSWAATL 529
                            |..|:..|  :..:...:.|..|| |:.....|..|:..||..
Zfish   435 ----------------DSSALNGG--FQPVNIKTARTADL-LTAPPDLTSAAALYRGPV------ 474

  Fly   530 TVEKPGSTSLHRAAD-------PSTYPAPPGTPKVLNVSRTSISLRWAKSQEKPGAVGP------ 581
                   .:||..||       |...|.|....||.|.|..      ...|:.|....|
Zfish   475 -------YALHDVADKIPMTNSPLLEPLPNLKIKVYNSSGL------VTPQDDPSDASPKLPRAL 526

  Fly   582 ----IIGYTVEYFSPDLQTGWIVAAQRVGDTQVTISG--LTPGTSYVFLVRAENTQGISVPSG-- 638
                .||......:..|...|..:....|... .:.|  :.|.:....||.|.     ::|.|
Zfish   527 LDGDTIGRRTHTQTQTLMRCWDPSCTAFGSFN-ALGGHLIVPNSGVSLLVPAG-----AIPQGRV 585

  Fly   639 --LSNTI---KTIEADFDAASANDLSAARTLLTGKSVELIDASAI-----NASAVRLEWMLHVSA 693
              :..|:   :::....|.|....||.  .:..|....|:....|     .|.|...:|::.:.:
Zfish   586 YEMYVTVHRKESMRPQVDDAQETVLSP--VVSCGPPGSLLTRPVILTMHHCAEADSEDWLIQLKS 648

  Fly   694 DEKYVEGLRIHYKDASVPSAQYHSITVMDASAESFVVGNLKKYTKYEFFLTPFFETIEGQPSNSK 758
            ..:               ..|:..:.         |||.       |.|.||.:..::.:..:..
Zfish   649 QSQ---------------QGQWEDVV---------VVGE-------ENFTTPCYIQLDAEACHLL 682

  Fly   759 T------ALTYEDVPSAPPDNIQIGMY 779
            |      .||.:.|.:|....:::.::
Zfish   683 TETLGTYCLTGQSVSAATTKRLKLAIF 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo1	NP_476899.1	Ig	56..151	CDD:299845	28/113 (25%)
		I-set	56..150	CDD:254352	28/112 (25%)
		I-set	157..251	CDD:254352	30/93 (32%)
		Ig2_Robo	159..251	CDD:143201	29/91 (32%)
		I-set	255..341	CDD:254352	13/86 (15%)
		Ig3_Robo	272..341	CDD:143202	13/69 (19%)
		IG_like	351..436	CDD:214653	20/99 (20%)
		Ig	362..444	CDD:299845	17/89 (19%)
		I-set	445..531	CDD:254352	12/85 (14%)
		IGc2	459..521	CDD:197706	9/61 (15%)
		FN3	549..637	CDD:238020	19/99 (19%)
		FN3	673..762	CDD:238020	13/99 (13%)
		fn3	770..855	CDD:278470	0/10 (0%)
unc5cb	NP_001093454.1	I-set	169..257	CDD:254352	30/93 (32%)
		Ig	171..257	CDD:299845	29/91 (32%)
		TSP1	263..314	CDD:214559	11/56 (20%)
		TSP1	319..367	CDD:214559	6/47 (13%)
		ZU5	549..653	CDD:128514	19/126 (15%)
		Death_UNC5C	866..948	CDD:260064
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910